Biography

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Dr. de Lemos is Professor of medicine and holds the Sweetheart Ball-Kern Wildenthal, MD, PhD Distinguished Chair in Cardiology.  He is the Cardiology Service Chief at Parkland Memorial Hospital where he also serves as CCU Director.  He was the director of the Cardiology Fellowship at UT Southwestern from 2005-2011. He is an active investigator in the Donald W. Reynolds Cardiovascular Research Center at UT Southwestern, and the Medical Director of the Dallas Heart Study.   He has chaired or co-chaired several research planning committees at UT Southwestern.  His primary research interests are in early detection, risk assessment and management of cardiovascular disease, with a particular focus on the role of cardiovascular biomarkers.  His research has evaluated existing biomarkers such as B-type natriuretic peptide, C-reactive protein and cardiac troponins as well as novel biomarkers reflecting biological pathways of disease.  He was the lead author of the Z phase of the A to Z trial, an international trial investigating different cholesterol lowering strategies in patients with acute coronary syndromes.  He graduated from Harvard Medical School and completed an Internal Medicine Residency at UT Southwestern Medical Center, where he also served as Chief Medical Resident.  He completed a fellowship in Cardiovascular Medicine and served on the faculty at the Brigham and Women’s Hospital before returning to UT Southwestern Medical School.  He has served on multiple committees of the AHA and ACC and is on the editorial board of the Journal of the American College of Cardiology, the American Journal of Cardiology and the American Heart Journal.  He has mentored >25 post-doctoral research trainees and has authored or coauthored over 250 manuscripts or book chapters and won several teaching awards. He sees patients with a broad range of cardiac problems, but specializes in those with chest pain and coronary artery disease.

Education

Medical School
Harvard Medical School (1992)
Internship
UT Southwestern Medical Center (1993), Internal Medicine
Residency
UT Southwestern Medical Center (1995), Internal Medicine
Chief Resident
UT Southwestern Medical Center (1996), Internal Medicine
Fellowship
Harvard Medical School (1999), Cardiology

Research Interest

  • Acute Coronary Syndromes
  • Cardiac Biomarkers
  • Lipid Lowering Therapy
  • Screening for Cardiovascular Disease

Publications

Featured Publications LegendFeatured Publications

Sex differences in the relationship between C-reactive protein and body fat.
Khera A, Vega GL, Das SR, Ayers C, McGuire DK, Grundy SM, de Lemos JA J. Clin. Endocrinol. Metab. 2009 Sep 94 9 3251-8
Clinical presentation and angiographic characteristics of saphenous vein graft failure after stenting: insights from the SOS (stenting of saphenous vein grafts) trial.
Lichtenwalter C, de Lemos JA, Roesle M, Obel O, Holper EM, Haagen D, Saeed B, Iturbe JM, Shunk K, Bissett JK, Sachdeva R, Voudris VV, Karyofillis P, Kar B, Rossen J, Fasseas P, Berger P, Banerjee S, Brilakis ES JACC Cardiovasc Interv 2009 Sep 2 9 855-60
Association between circulating soluble receptor for advanced glycation end products and atherosclerosis: observations from the Dallas Heart Study.
Lindsey JB, de Lemos JA, Cipollone F, Ayers CR, Rohatgi A, Morrow DA, Khera A, McGuire DK Diabetes Care 2009 Jul 32 7 1218-20
Biomarkers and cardiovascular disease: determining causality and quantifying contribution to risk assessment.
Shah SH, de Lemos JA JAMA 2009 Jul 302 1 92-3
Evaluation of coronary artery calcium screening strategies focused on risk categories: the Dallas Heart Study.
Patel MJ, de Lemos JA, McGuire DK, See R, Lindsey JB, Murphy SA, Grundy SM, Khera A Am. Heart J. 2009 Jun 157 6 1001-9
Native LDL-cholesterol mediated monocyte adhesion molecule overexpression is blocked by simvastatin.
Serrano CV, Pesaro AE, de Lemos JA, Rached F, Segre CA, Gomes F, Ribeiro AF, Nicolau JC, Yoshida VM, Monteiro HP Cardiovasc Drugs Ther 2009 Jun 23 3 215-20
The report card on growth differentiation factor 15: consistent marks but not yet ready for promotion.
Rohatgi A, de Lemos JA Circ Cardiovasc Genet 2009 Jun 2 3 209-11
Fracture and embolization of an inferior vena cava filter strut leading to cardiac tamponade.
Rogers NA, Nguyen L, Minniefield NE, Jessen ME, de Lemos JA Circulation 2009 May 119 18 2535-6
Relationship of oxidized phospholipids on apolipoprotein B-100 particles to race/ethnicity, apolipoprotein(a) isoform size, and cardiovascular risk factors: results from the Dallas Heart Study.
Tsimikas S, Clopton P, Brilakis ES, Marcovina SM, Khera A, Miller ER, de Lemos JA, Witztum JL Circulation 2009 Apr 119 13 1711-9
Screening the population for left ventricular hypertrophy and left ventricular systolic dysfunction using natriuretic peptides: results from the Dallas Heart Study.
de Lemos JA, McGuire DK, Khera A, Das SR, Murphy SA, Omland T, Drazner MH Am. Heart J. 2009 Apr 157 4 746-53.e2

Books

Featured Books Legend Featured Books

Unstable Angina and Non-ST Elevation Myocardial Infarction. In Hurst's the Heart, 13th ed

de Lemos JA, O'Rourke RA, Harrington RA (2011). McGraw Hill

ST Elevation Myocardial infarction. In Irwin and Rippe?s Intensive Care Medicine 7th edition

de Lemos JA and Morrow DA (2011). William and Wilkins

Honors & Awards

  • Simon Dack Award for Medical Publications
    Journal of the American College of Cardiology (2012)
  • Association of University Cardiologists
    (2011)
  • Best Doctors in Dallas, Cardiology
    D Magazine (2011)
  • Core Clerkship Teaching Award
    UT Southwestern (2011)
  • Super Doctors, Cardiology
    Texas Monthly (2011)
  • Best Doctors in Dallas, Cardiology
    D Magazine (2010)
  • Super Doctors, Cardiology
    Texas Monthly (2010)
  • Sweetheart Ball-Kern Wildenthal MD, PhD Distinguished Chair
    Distinguished Chair in Cardiology (2009)
  • Elite Reviewer
    Journal of the American College of Cardiology (2006)
  • Best Doctors in Dallas, Cardiology
    D Magazine (2005)
  • Internal Medicine Teaching Award
    Excellence in Teaching (2005)
  • Eugene Braunwald Fellowship
    Excellence in Clinical Research, Brigham and Women’s Hospital (1999)
  • Soma Weiss Award
    Excellence in Teaching, Brigham and Women’s Hospital (1997)

Professional Associations/Affiliations

  • Society of Chest Pain Physicians (2011)
  • AHA/ACC ST Elevation MI Guideline Committee (2010-2012)
  • Chair, Research and Publications Committee (2010)
  • American Heart Association (1998)
  • American College of Cardiology (1996)