Dr. Raj completed his doctoral training from JU, Gwalior, India. His Ph.D. thesis work was focused on epidemiological and genetic analysis of pulmonary tuberculosis in tribal groups of central India. One of the interesting findings from this work was establishment of LDH2 & LDH3 isoforms as markers of mycobacterial infection load induced cellular stress in TB patients. His research showed that noncoding genetic polymorphisms in Vitamin D receptor (VDR) gene are associated with clinical manifestations of pulmonary TB.
During his postdoctoral training in Wakeland laboratory in the department of immunology at UT Southwestern Medical center, he investigated genetic basis of Systemic Lupus Erythematosus (SLE). Using deep targeted sequencing approach, he made an important discovery demonstrating abundance of SLE associated noncoding, regulatory variations at HLA locus that impact transcription of several key genes of immune system that activate antigen presentation pathway to potentiate autoimmunity in individuals with risk genotype.
Dr. Raj, joined the faculty of Immunology at UT Southwestern Medical Center in September 2018. He is the Director of newly established Microbiome Research Laboratory (MRL) that provide cutting edge facilities to investigate and characterize communities of microorganisms sampled from variety of sources. Dr. Raj and his team at MRL provide microbial sequencing services to basic and translational investigators that are interested in microbiome research.
- Immune system and host genetics
- Microbial genomics
- Microbiome in health and disease
- Next generation sequencing
- Utility of serum LDH isoforms in the assessment of mycobacterium tuberculosis induced pathology in TB patients of Sahariya tribe.
- Sharma PR, Jain S, Bamezai RN, Tiwari PK Indian J Clin Biochem 2010 Jan 25 1 57-63
- The Indian origin of paternal haplogroup R1a1* substantiates the autochthonous origin of Brahmins and the caste system.
- Sharma S, Rai E, Sharma P, Jena M, Singh S, Darvishi K, Bhat AK, Bhanwer AJ, Tiwari PK, Bamezai RN J. Hum. Genet. 2009 Jan 54 1 47-55
- Elevated level of serum LDH2 and LDH3 in sputum three positive TB patients of Sahariya tribe: a preliminary study.
- Sharma PR, Jain S, Tiwari PK Clin. Biochem. 2007 Dec 40 18 1414-9
Genetic diversity in Indian populations: Implications for genetic susceptibility and mapping of complex genetic diseases. In Recent Trends in Biotechnology
Raj P. & P K Tiwari. (2010). New York, ) NOVA publisher, New York
Honors & Awards
- Outstanding paper award for Staphylococcus aureus genome study in children
Pediatric Orthopaedic Society of North America & European Pediatric Orthopaedic Society, USA (2017-2017)
- Best Poster award
Immunology symposium, Department of Immunology symposium UTSW, Dallas, Texas, USA (2012)
- Young Scientist Award
Madhya Pradesh Council of Science & Technology (MPCST), India (2009)
- Best Poster award
International conference of Medical and Community Genetics at Department of Hematology, India (2008)
- Travel award from CSIR and DBT, India
57th Annual Meeting of American Society of Human Genetics (2007)
- University Topper Research Scholarship, University Grant Commission (UGC)
Jiwaji University, Gwalior, M. P. India (2004-2006)
- American Association of Immunologists (AAI) (2013)
- American Society of Human Genetics (ASHG) (2007)
- Indian Society of Human Genetics (ISHG) (2006)