Biography

Dr. Jeff SoRelle is from Waco and earned his B.S. degree in Chemistry from Centre College in Danville, Kentucky before returning to Texas for medical school at UT Southwestern. First through an AOA summer fellowship and subsequently for a year as a Howard Hughes Research Fellow, Jeff worked in the lab of 2011 Nobel Prize winnerDr. Bruce Beutler, screening mutagenized mice for genetic regulators of the allergic IgE antibody response.

Upon graduating medical school, Dr. SoRelle completed a residency in Clinical Pathology and fellowship in Molecular Genetic Pathology at UT Southwestern. He completed clinic genetic research projects examining interpretation of inherited genetic diseases. Dr. SoRelle served as Chief Resident and won the Weinberg Resident Research award in 2020 upon graduating Clinical Pathology (CP only) residency. As an assistant instructor, Dr. SoRelle continued basic science research with the Physician Scientist Training Program. He bridges his clinical and research training in the Next Generation Sequencing Laboratory. There, he has developed several advanced COVID-19 molecular assays and co-leads the UTSW effort to monitor COVID-19 Variants of Concern, which he writes about as a regular contributor of LABLOGATORY, a blog for Laboratory Medicine Professionals.

He is continues investigation of the genetics of allergy, as he opens a new lab. Our lab aims to discover the reasons people get allergies at a genetic level. Then we can translate these findings into diagnostic and therapeutic solutions for patients with allergy. With aggressive enthusiasm, we will follow the data to achieve our aims with teamwork as a guiding principle. We will advance the careers of lab members by developing excellent written and verbal communication skills. 

Education

Medical School
UT Southwestern Medical School (2016)
Residency
UT Southwestern Medical Center (2018), Pathology
Fellowship
UT Southwestern Medical Center (2019), Molecular Genetics
Residency
UT Southwestern Medical Center (2020), Pathology

Research Interest

  • COVID-19 Diagnostics
  • Genetics of Allergy
  • Genomic Re-interpretation
  • Immunology
  • Laboratory's role in Transgender Health

Publications

Featured Publications LegendFeatured Publications

Laboratory Action Plan for Emerging SARS-CoV-2 Variants.
Filkins L, SoRelle JA, Schoggins J, Park JY, Clin Chem 2021 04 67 5 720-723
Dominant atopy risk mutations identified by mouse forward genetic analysis.
SoRelle JA, Chen Z, Wang J, Yue T, Choi JH, Wang KW, Zhong X, Hildebrand S, Russell J, Scott L, Xu D, Zhan X, Bu CH, Wang T, Choi M, Tang M, Ludwig S, Zhan X, Li X, Moresco EMY, Beutler B, Allergy 2021 04 76 4 1095-1108
Different Interpretations of the Same Genetic Data.
SoRelle JA, Gemmell AP, Ross TS, Ann. Intern. Med. 2020 Jun
Assessment of Interlaboratory Variation in the Interpretation of Genomic Test Results in Patients With Epilepsy.
SoRelle JA, Pascual JM, Gotway G, Park JY, JAMA Netw Open 2020 Apr 3 4 e203812
Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation.
Misawa T, SoRelle JA, Choi JH, Yue T, Wang KW, McAlpine W, Wang J, Liu A, Tabeta K, Turer EE, Evers B, Nair-Gill E, Poddar S, Su L, Ou F, Yu L, Russell J, Ludwig S, Zhan X, Hildebrand S, Li X, Tang M, Murray AR, Moresco EMY, Beutler B, Sci Immunol 2020 Jan 5 43
Impact of Hormone Therapy on Laboratory Values in Transgender Patients.
SoRelle JA, Jiao R, Gao E, Veazey J, Frame I, Quinn AM, Day P, Pagels P, Gimpel N, Patel K Clin. Chem. 2019 Jan 65 1 170-179
Clinical Utility of Reinterpreting Previously Reported Genomic Epilepsy Test Results for Pediatric Patients.
SoRelle JA, Thodeson DM, Arnold S, Gotway G, Park JY JAMA Pediatr 2018 Nov e182302
Real-time resolution of point mutations that cause phenovariance in mice.
Wang T, Zhan X, Bu CH, Lyon S, Pratt D, Hildebrand S, Choi JH, Zhang Z, Zeng M, Wang KW, Turer E, Chen Z, Zhang D, Yue T, Wang Y, Shi H, Wang J, Sun L, SoRelle J, McAlpine W, Hutchins N, Zhan X, Fina M, Gobert R, Quan J, Kreutzer M, Arnett S, Hawkins K, Leach A, Tate C, Daniel C, Reyna C, Prince L, Davis S, Purrington J, Bearden R, Weatherly J, White D, Russell J, Sun Q, Tang M, Li X, Scott L, Moresco EM, McInerney GM, Karlsson Hedestam GB, Xie Y, Beutler B Proc. Natl. Acad. Sci. U.S.A. 2015 Jan

Honors & Awards

  • Weinberg Resident Research award
    (2020)
  • Vernie Stembridge Award
    Academic Excellence in Pathology. (2016)

Professional Associations/Affiliations

  • American Association of Immunologists (2017)
  • American Association of Immunologists (2017)