David Corey, Ph.D.

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Dr. David R. Corey was born in Cambridge. Mass., August 13, 1963. He received his BA degree in Chemistry from Harvard University in 1985, and his PhD in Chemistry from the University of California at Berkeley in 1990. He completed postdoctoral training with Dr. Charles Craik in the Department of Pharmaceutical Chemistry at the University of California at San Francisco (1990-1992). In 1992 Dr. Corey joined the faculty of the Department of Pharmacology at the University of Texas Southwestern Medical Center at Dallas as an Assistant Professor. In 1996 Dr. Corey received a secondary appointment to the Department of Biochemistry, and in 1998 he was promoted to Associate Professor and to Full Professor in 2003.

Undergraduate

Harvard University , Chemistry

Graduate School

Univ of California-Berkeley (1990)

• antigene oligonucleotides
• antisense oligonucleotides
• Nucleic acids
• RNAi
• Telomerase
• Trinucleotide repeat disease

Featured Publications

Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs.

Shen X, Corey DR Nucleic Acids Res. 2017 Dec

Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.

Hicks JA, Li L, Matsui M, Chu Y, Volkov O, Johnson KC, Corey DR Cell Rep 2017 Aug 20 7 1543-1552

Nusinersen, an antisense oligonucleotide drug for spinal muscular atrophy.

Corey DR Nat. Neurosci. 2017 Feb

c9orf72 Disease-Related Foci Are Each Composed of One Mutant Expanded Repeat RNA.

Liu J, Hu J, Ludlow AT, Pham JT, Shay JW, Rothstein JD, Corey DR Cell Chem Biol 2017 Jan

Non-coding RNAs as drug targets.

Matsui M, Corey DR Nat Rev Drug Discov 2016 Jul

Activating frataxin expression by repeat-targeted nucleic acids.

Li L, Matsui M, Corey DR Nat Commun 2016 7 10606

Regulation of mammalian transcription and splicing by Nuclear RNAi.

Kalantari R, Chiang CM, Corey DR Nucleic Acids Res. 2015 Nov

RNAi Factors Are Present and Active in Human Cell Nuclei.

Gagnon KT, Li L, Chu Y, Janowski BA, Corey DR Cell Rep 2014 Jan 6 1 211-21

Promoter RNA links transcriptional regulation of inflammatory pathway genes.

Matsui M, Chu Y, Zhang H, Gagnon KT, Shaikh S, Kuchimanchi S, Manoharan M, Corey DR, Janowski BA Nucleic Acids Res. 2013 Sep

Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression.

Yu D, Pendergraff H, Liu J, Kordasiewicz HB, Cleveland DW, Swayze EE, Lima WF, Crooke ST, Prakash TP, Corey DR Cell 2012 Aug 150 5 895-908

• Gilman Special Opportunity Award
  (2017-2018)
• Excellence Postdoctoral Mentoring Award
  (2010)
• McKnight Neuroscience Award
  (2009)
• Welch Lectueship
  (2003)
• CaP Cure Research Award
  (1996)
• Damon Runyon Postdoctoral Fellowship
  (1990)

• Oligonucleotide Therapeutics Society (2005)
• American Chemical Society (1990)