Ralf Kittler, Ph.D.

• Cancer Biology
• Cancer Therapeutics
• Genomics
• Nuclear Receptors
• Transcription Factors
• Transcriptional Regulation

 Featured Publications

RNA interference rescue by bacterial artificial chromosome transgenesis in mammalian tissue culture cells

Kittler R, Pelletier L, Ma C, Poser I, Fischer S, Hyman AA, Buchholz F PNAS February 2005 102(7) 2396-401

An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division

Kittler R, Putz G, Pelletier L, Poser I, Heninger AK, Drechsel D, Fischer S, Konstantinova I, Habermann B, Grabner H, Yaspo ML, Himmelbauer H, Korn B, Neugebauer K, Pisabarro MT, Buchholz F Nature December 2004 432(7020) 1036-40

Global chromatin landscapes identify candidate noncoding modifiers of cardiac rhythm.

Bhattacharyya S, Kollipara RK, Orquera-Tornakian G, Goetsch S, Zhang M, Perry C, Li B, Shelton JM, Bhakta M, Duan J, Xie Y, Xiao G, Evers BM, Hon GC, Kittler R, Munshi NV, J Clin Invest 2023 Feb 133 3

Ablation of EWS-FLI1 by USP9X inhibition suppresses cancer cell growth in Ewing sarcoma.

Wang S, Huo X, Yang Y, Mo Y, Kollipara RK, Kittler R, Cancer Lett 2023 Jan 552 215984

Dynamic differences between DNA damage repair responses in primary tumors and cell lines.

Gilbreath C, Ma S, Yu L, Sonavane R, Roggero CM, Devineni A, Mauck R, Desai NB, Bagrodia A, Kittler R, Raj GV, Yin Y, Transl Oncol 2021 Jan 14 1 100898

Hormonal modulation of ESR1 mutant metastasis.

Gu G, Tian L, Herzog SK, Rechoum Y, Gelsomino L, Gao M, Du L, Kim JA, Dustin D, Lo HC, Beyer AR, Edwards DG, Gonzalez T, Tsimelzon A, Huang HJ, Fernandez NM, Grimm SL, Hilsenbeck SG, Liu D, Xu J, Alaniz A, Li S, Mills GB, Janku F, Kittler R, Zhang XH, Coarfa C, Foulds CE, Symmans WF, Andò S, Fuqua SAW, Oncogene 2020 Dec

Mithramycin suppresses DNA damage repair via targeting androgen receptor in prostate cancer.

Wang S, Gilbreath C, Kollipara RK, Sonavane R, Huo X, Yenerall P, Das A, Ma S, Raj GV, Kittler R, Cancer Lett. 2020 Sep 488 40-49

Radiation-induced DNA damage cooperates with heterozygosity of TP53 and PTEN to generate high grade gliomas.

Todorova PK, Fletcher-Sananikone E, Mukherjee B, Kollipara R, Vemireddy V, Xie XJ, Guida PM, Story MD, Hatanpaa K, Habib AA, Kittler R, Bachoo R, Hromas R, Floyd JR, Burma S, Cancer Res. 2019 May

PPAR?-K107 SUMOylation regulates insulin sensitivity but not adiposity in mice.

Katafuchi T, Holland WL, Kollipara RK, Kittler R, Mangelsdorf DJ, Kliewer SA Proc. Natl. Acad. Sci. U.S.A. 2018 11 115 48 12102-12111

Targeting the turnover of oncoproteins as a new avenue for therapeutics development in castration-resistant prostate cancer.

Wang S, Ekoue DN, Raj GV, Kittler R Cancer Lett. 2018 Sep 438 86-96

• CPRIT Scholar in Cancer Research
  Cancer Prevention and Research Institute of Texas (2010)
• John L Roach Scholar in Biomedical Research
  Endowed Scholars Program in Medical Research (2010)
• Long-term Fellowship
  Human Frontier Science Program Organization (2007)
• Otto Hahn Medal
  Max Planck Society (2007)
• Undergraduate Fellowship
  German National Academic Foundation (1998)

• AACR (2014)