
Ralf Kittler, Ph.D.
Associate Professor
Endowed Title John L. Roach Scholar in Biomedical Research
School Medical School
Department Eugene McDermott Center for Human Growth and Development | Harold C. Simmons Comprehensive Cancer Center | Pharmacology
Graduate Programs Cancer Biology
Education
- Graduate School
- Universitat Leipzig (2002), Biochemistry
- Graduate School
- Technische Universitat Dresden (2006), Molecular Biology
Research Interest
- Cancer Biology
- Cancer Therapeutics
- Genomics
- Nuclear Receptors
- Transcription Factors
- Transcriptional Regulation
Publications
Featured Publications
- Lentiviral-driven discovery of cancer drug resistance mutations.
- Yenerall P, Kollipara RK, Avila K, Peyton M, Eide CA, Bottomly D, McWeeney SK, Liu Y, Westover KD, Druker BJ, Minna JD, Kittler R, Cancer Res 2021 Jul
- RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer.
- Yenerall P, Das AK, Wang S, Kollipara RK, Li LS, Villalobos P, Flaming J, Lin YF, Huffman K, Timmons BC, Gilbreath C, Sonavane R, Kinch LN, Rodriguez-Canales J, Moran C, Behrens C, Hirasawa M, Takata T, Murakami R, Iwanaga K, Chen BPC, Grishin NV, Raj GV, Wistuba II, Minna JD, Kittler R, Cell Chem Biol 2019 Dec
- Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma.
- Singh DK, Kollipara RK, Vemireddy V, Yang XL, Sun Y, Regmi N, Klingler S, Hatanpaa KJ, Raisanen J, Cho SK, Sirasanagandla S, Nannepaga S, Piccirillo S, Mashimo T, Wang S, Humphries CG, Mickey B, Maher EA, Zheng H, Kim RS, Kittler R, Bachoo RM Cell Rep 2017 Jan 18 4 961-976
- The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.
- Wang S, Kollipara RK, Humphries CG, Ma SH, Hutchinson R, Li R, Siddiqui J, Tomlins SA, Raj GV, Kittler R Oncotarget 2016 Sep
- Inhibition of Cancer Cell Proliferation by PPAR? Is Mediated by a Metabolic Switch that Increases Reactive Oxygen Species Levels.
- Srivastava N, Kollipara RK, Singh DK, Sudderth J, Hu Z, Nguyen H, Wang S, Humphries CG, Carstens R, Huffman KE, DeBerardinis RJ, Kittler R Cell Metab. 2014 Sep
- Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.
- Wang S, Kollipara RK, Srivastava N, Li R, Ravindranathan P, Hernandez E, Freeman E, Humphries CG, Kapur P, Lotan Y, Fazli L, Gleave ME, Plymate SR, Raj GV, Hsieh JT, Kittler R Proc. Natl. Acad. Sci. U.S.A. 2014 Mar 111 11 4251-6
- A comprehensive nuclear receptor network for breast cancer cells.
- Kittler R, Zhou J, Hua S, Ma L, Liu Y, Pendleton E, Cheng C, Gerstein M, White KP Cell Rep 2013 Feb 3 2 538-51
- Genomic antagonism between retinoic acid and estrogen signaling in breast cancer
- Hua S, Kittler R, White KP Cell June 2009 137(7) 1259-71
- Genome-scale RNAi profiling of cell division in human tissue culture cells
- Kittler R, Pelletier L, Heninger AK, Slabicki M, Theis M, Miroslaw L, Poser I, Lawo S, Grabner H, Kozak K, Wagner J, Surendranath V, Richter C, Bowen W, Jackson AL, Habermann B, Hyman AA, Buchholz F Nature Cell Biology December 2007 9(12) 1401-12
- Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies
- Kittler R, Surendranath V, Heninger AK, Slabicki M, Theis M, Putz G, Franke K, Caldarelli A, Grabner H, Kozak K, Wagner J, Rees E, Korn B, Frenzel C, Sachse C, Sonnichsen B, Guo J, Schelter J, Burchard J, Linsley PS, Jackson AL, Habermann B, Buchholz F Nature Methods April 2007 4(4) 337-44
Honors & Awards
- CPRIT Scholar in Cancer Research
Cancer Prevention and Research Institute of Texas (2010) - John L Roach Scholar in Biomedical Research
Endowed Scholars Program in Medical Research (2010) - Long-term Fellowship
Human Frontier Science Program Organization (2007) - Otto Hahn Medal
Max Planck Society (2007) - Undergraduate Fellowship
German National Academic Foundation (1998)
Professional Associations/Affiliations
- AACR (2014)