Ralf Kittler, Ph.D.

Graduate School

Universitat Leipzig (2002), Biochemistry

Graduate School

Technische Universitat Dresden (2006), Molecular Biology

• Cancer Biology
• Cancer Therapeutics
• Genomics
• Nuclear Receptors
• Transcription Factors
• Transcriptional Regulation

Featured Publications

Lentiviral-driven discovery of cancer drug resistance mutations.

Yenerall P, Kollipara RK, Avila K, Peyton M, Eide CA, Bottomly D, McWeeney SK, Liu Y, Westover KD, Druker BJ, Minna JD, Kittler R, Cancer Res 2021 Jul

RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer.

Yenerall P, Das AK, Wang S, Kollipara RK, Li LS, Villalobos P, Flaming J, Lin YF, Huffman K, Timmons BC, Gilbreath C, Sonavane R, Kinch LN, Rodriguez-Canales J, Moran C, Behrens C, Hirasawa M, Takata T, Murakami R, Iwanaga K, Chen BPC, Grishin NV, Raj GV, Wistuba II, Minna JD, Kittler R, Cell Chem Biol 2019 Dec

Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma.

Singh DK, Kollipara RK, Vemireddy V, Yang XL, Sun Y, Regmi N, Klingler S, Hatanpaa KJ, Raisanen J, Cho SK, Sirasanagandla S, Nannepaga S, Piccirillo S, Mashimo T, Wang S, Humphries CG, Mickey B, Maher EA, Zheng H, Kim RS, Kittler R, Bachoo RM Cell Rep 2017 Jan 18 4 961-976

The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.

Wang S, Kollipara RK, Humphries CG, Ma SH, Hutchinson R, Li R, Siddiqui J, Tomlins SA, Raj GV, Kittler R Oncotarget 2016 Sep

Inhibition of Cancer Cell Proliferation by PPAR? Is Mediated by a Metabolic Switch that Increases Reactive Oxygen Species Levels.

Srivastava N, Kollipara RK, Singh DK, Sudderth J, Hu Z, Nguyen H, Wang S, Humphries CG, Carstens R, Huffman KE, DeBerardinis RJ, Kittler R Cell Metab. 2014 Sep

Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.

Wang S, Kollipara RK, Srivastava N, Li R, Ravindranathan P, Hernandez E, Freeman E, Humphries CG, Kapur P, Lotan Y, Fazli L, Gleave ME, Plymate SR, Raj GV, Hsieh JT, Kittler R Proc. Natl. Acad. Sci. U.S.A. 2014 Mar 111 11 4251-6

A comprehensive nuclear receptor network for breast cancer cells.

Kittler R, Zhou J, Hua S, Ma L, Liu Y, Pendleton E, Cheng C, Gerstein M, White KP Cell Rep 2013 Feb 3 2 538-51

Genomic antagonism between retinoic acid and estrogen signaling in breast cancer

Hua S, Kittler R, White KP Cell June 2009 137(7) 1259-71

Genome-scale RNAi profiling of cell division in human tissue culture cells

Kittler R, Pelletier L, Heninger AK, Slabicki M, Theis M, Miroslaw L, Poser I, Lawo S, Grabner H, Kozak K, Wagner J, Surendranath V, Richter C, Bowen W, Jackson AL, Habermann B, Hyman AA, Buchholz F Nature Cell Biology December 2007 9(12) 1401-12

Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies

Kittler R, Surendranath V, Heninger AK, Slabicki M, Theis M, Putz G, Franke K, Caldarelli A, Grabner H, Kozak K, Wagner J, Rees E, Korn B, Frenzel C, Sachse C, Sonnichsen B, Guo J, Schelter J, Burchard J, Linsley PS, Jackson AL, Habermann B, Buchholz F Nature Methods April 2007 4(4) 337-44

• CPRIT Scholar in Cancer Research
  Cancer Prevention and Research Institute of Texas (2010)
• John L Roach Scholar in Biomedical Research
  Endowed Scholars Program in Medical Research (2010)
• Long-term Fellowship
  Human Frontier Science Program Organization (2007)
• Otto Hahn Medal
  Max Planck Society (2007)
• Undergraduate Fellowship
  German National Academic Foundation (1998)

• AACR (2014)