W. Lee Kraus, Ph.D. is a Professor of Obstetrics & Gynecology and Pharmacology, Director of the Cecil H. and Ida Green Center for Reproductive Biology Sciences, and Vice Chair for Basic Sciences in the Department of Obstetrics & Gynecology at UT Southwestern Medical Center in Dallas. He is a trained biochemist, molecular biologist, and physiologist who has interests in hormone action, nuclear signaling pathways, chromatin structure, transcription, and the regulation of gene expression in biological systems including reproduction, inflammation, metabolism, stem cells, and cancer. His laboratory applies a broad array of approaches, from biophysics, biochemistry, and molecular biology, to cell biology, genomics, and mouse genetics, to study the detailed molecular mechanisms that control normal and disease phenotypes.
Dr. Kraus received a B.S. in Physiology from Cornell University in 1989 and completed his graduate research on the regulation of steroid hormone receptor activity in the laboratory of Dr. Benita S. Katzenellenbogen at the University of Illinois, Urbana-Champaign in 1994. He completed his postdoctoral research on the mechanisms of transcriptional regulation with chromatin in the laboratory of Dr. Jim Kadonaga at the University of California, San Diego in 1999. During his postdoctoral work, Dr. Kraus was supported by fellowships from the National Institutes of Health and the American Cancer Society, California Division.
Prior to joining the faculty at UT Southwestern, Dr. Kraus was a professor in the Department of Molecular Biology and Genetics at Cornell University in Ithaca, New York in 1999. He also held a joint appointment in the Department of Pharmacology at the Weill Medical College of Cornell University in New York City.
In July 2010, Dr. Kraus moved to UT Southwestern Medical Center in Dallas where he holds the Cecil H. and Ida Green Distinguished Chair in Reproductive Biology Sciences. He has received numerous awards, including a Burroughs Wellcome Fund Career Award in the Biomedical Sciences, the Cornell University College of Agriculture and Life Sciences Young Faculty Teaching Excellence Award, and the Richard E. Weitzman Memorial Award from the Endocrine Society.
Dr. Kraus has been supported by a Career Award in the Biomedical Sciences/Reproductive Biology from the Burroughs Wellcome Fund, as well as grants from the National Institutes of Health, Cancer Prevention Research Institute of Texas, the American Cancer Society, the Endocrine Society, and the Komen Breast Cancer Foundation.
Dr. Kraus is a founder of Ribon Therapeutics. Ribon Therapeutics is pioneering the discovery and development of PARP monoenzyme inhibitors to block cancer cells' fundamental ability to survive under stress.
- Cornell University (1989), Animal Science
- Graduate School
- Univ of Illinois @ Urbana-Cham (1991), Physiology
- Graduate School
- Univ of Illinois @ Urbana-Cham (1994), Physiology
- Cancer biology (esp. breast cancer)
- Chromatin structure and gene regulation
- Computational genomics
- Hormonal signaling
- Molecular physiology of reproduction, inflammation, and adipogenesis
- Identification of active transcriptional regulatory elements from GRO-seq data.
- Danko CG, Hyland SL, Core LJ, Martins AL, Waters CT, Lee HW, Cheung VG, Kraus WL, Lis JT, Siepel A Nat. Methods 2015 Mar
- TNFa Signaling Exposes Latent Estrogen Receptor Binding Sites to Alter the Breast Cancer Cell Transcriptome.
- Franco HL, Nagari A, Kraus WL Mol. Cell 2015 Mar
- groHMM: a computational tool for identifying unannotated and cell type-specific transcription units from global run-on sequencing data.
- Chae M, Danko CG, Kraus WL BMC Bioinformatics 2015 16 222
- Enhancer Transcripts Mark Active Estrogen Receptor Binding Sites.
- Hah N, Murakami S, Nagari A, Danko C, Kraus WL Genome Res. 2013 May
- Signaling Pathways Differentially Affect RNA Polymerase II Initiation, Pausing, and Elongation Rate in Cells.
- Danko CG, Hah N, Luo X, Martins AL, Core L, Lis JT, Siepel A, Kraus WL Mol. Cell 2013 Mar
- A rapid, extensive, and transient transcriptional response to estrogen signaling in breast cancer cells.
- Hah N, Danko CG, Core L, Waterfall JJ, Siepel A, Lis JT, Kraus WL Cell 2011 May 145 4 622-34
- PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway.
- Krishnakumar R, Kraus WL Mol. Cell 2010 Sep 39 5 736-49
- Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes.
- Krishnakumar R, Gamble MJ, Frizzell KM, Berrocal JG, Kininis M, Kraus WL Science 2008 Feb 319 5864 819-21
- NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1.
- Kim MY, Mauro S, Gévry N, Lis JT, Kraus WL Cell 2004 Dec 119 6 803-14
- Ryu KW, Nandu T, Kim J, Challa S, DeBerardinis RJ, Kraus WL Science 2018 05 360 6389
Honors & Awards
- Cecil H. and Ida Green Distinguished Chair in Reproductive Biology Sciences
- Cornell University College of Agriculture and Life Sciences Excellence in Mentoring Undergraduate Students in Independent Research Award
- Richard E. Weitzman Memorial Award from the Endocrine Society
- Distinguished Alumni Award from the Department of Molecular and Integrative Physiology, University of Illinois, Urbana-Champaign
- Cornell University College of Agriculture and Life Sciences Young Faculty Teaching Excellence Award
- Burroughs Wellcome Fund Career Award in the Biomedical Sciences, Reproductive Biology