W. Lee Kraus, Ph.D. is a Professor of Obstetrics & Gynecology and Pharmacology, Director of the Cecil H. and Ida Green Center for Reproductive Biology Sciences, and Vice Chair for Basic Sciences in the Department of Obstetrics & Gynecology at UT Southwestern Medical Center in Dallas. He is a trained biochemist, molecular biologist, and physiologist who has interests in hormone action, nuclear signaling pathways, chromatin structure, transcription, and the regulation of gene expression in biological systems including reproduction, inflammation, metabolism, stem cells, and cancer. His laboratory applies a broad array of approaches, from biophysics, biochemistry, and molecular biology, to cell biology, genomics, and mouse genetics, to study the detailed molecular mechanisms that control normal and disease phenotypes.
Dr. Kraus received a B.S. in Physiology from Cornell University in 1989 and completed his graduate research on the regulation of steroid hormone receptor activity in the laboratory of Dr. Benita S. Katzenellenbogen at the University of Illinois, Urbana-Champaign in 1994. He completed his postdoctoral research on the mechanisms of transcriptional regulation with chromatin in the laboratory of Dr. Jim Kadonaga at the University of California, San Diego in 1999. During his postdoctoral work, Dr. Kraus was supported by fellowships from the National Institutes of Health and the American Cancer Society, California Division.
Prior to joining the faculty at UT Southwestern, Dr. Kraus was a professor in the Department of Molecular Biology and Genetics at Cornell University in Ithaca, New York in 1999. He also held a joint appointment in the Department of Pharmacology at the Weill Medical College of Cornell University in New York City.
In July 2010, Dr. Kraus moved to UT Southwestern Medical Center in Dallas where he holds the Cecil H. and Ida Green Distinguished Chair in Reproductive Biology Sciences. He has received numerous awards, including a Burroughs Wellcome Fund Career Award in the Biomedical Sciences, the Cornell University College of Agriculture and Life Sciences Young Faculty Teaching Excellence Award, and the Richard E. Weitzman Memorial Award from the Endocrine Society.
Dr. Kraus has been supported by a Career Award in the Biomedical Sciences/Reproductive Biology from the Burroughs Wellcome Fund, as well as grants from the National Institutes of Health, Cancer Prevention Research Institute of Texas, the American Cancer Society, the Endocrine Society, and the Komen Breast Cancer Foundation.
Dr. Kraus is a founder of Ribon Therapeutics. Ribon Therapeutics is pioneering the discovery and development of PARP monoenzyme inhibitors to block cancer cells' fundamental ability to survive under stress.
- Cornell University (1989), Animal Science
- Graduate School
- Univ of Illinois @ Urbana-Cham (1991), Physiology
- Graduate School
- Univ of Illinois @ Urbana-Cham (1994), Physiology
- Cancer biology (esp. breast cancer)
- Chromatin structure and gene regulation
- Computational genomics
- Hormonal signaling
- Molecular physiology of reproduction, inflammation, and adipogenesis
- Dynamic evolution of regulatory element ensembles in primate CD4+ T cells.
- Danko CG, Choate LA, Marks BA, Rice EJ, Wang Z, Chu T, Martins AL, Dukler N, Coonrod SA, Tait Wojno ED, Lis JT, Kraus WL, Siepel A Nat Ecol Evol 2018 Jan
- Identifying Genomic Sites of ADP-Ribosylation Mediated by Specific Nuclear PARP Enzymes Using Click-ChIP.
- Rogge RA, Gibson BA, Kraus WL Methods Mol. Biol. 2018 1813 371-387
- Metabolic regulation of transcription through compartmentalized NAD+ biosynthesis
- Ryu KW, Nandu T, Kim J, Challa S, DeBerardinis RJ, Kraus WL. Science 2018 11;360(6389). pii: eaan5780
- Enhancer transcription reveals subtype-specific gene expression programs controlling breast cancer pathogenesis.
- Franco HL, Nagari A, Malladi V, Li W, Xi Y, Richardson D, Allton KL, Tanaka K, Li J, Murakami S, Keyomarsi K, Bedford MT, Shi X, Li W, Barton MC, Dent SYR, Kraus WL Genome Res. 2017 Dec
- Generation and Characterization of Recombinant Antibody-Like ADP-Ribose Binding Proteins.
- Gibson BA, Conrad LB, Huang D, Kraus WL Biochemistry 2017 Oct
- Dynamic assembly and activation of estrogen receptor a enhancers through coregulator switching.
- Murakami S, Nagari A, Kraus WL Genes Dev. 2017 Aug 31 15 1535-1548
- Catalytic-Independent Functions of PARP-1 Determine Sox2 Pioneer Activity at Intractable Genomic Loci.
- Liu Z, Kraus WL Mol. Cell 2017 Feb 65 4 589-603.e9
- PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPß and Modulating Its Transcriptional Activity.
- Luo X, Ryu KW, Kim DS, Nandu T, Medina CJ, Gupte R, Gibson BA, Soccio RE, Yu Y, Gupta RK, Kraus WL Mol. Cell 2017 Jan 65 2 260-271
- Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation.
- Gibson BA, Zhang Y, Jiang H, Hussey KM, Shrimp JH, Lin H, Schwede F, Yu Y, Kraus WL Science 2016 Jul 353 6294 45-50
- Discovery, Annotation, and Functional Analysis of Long Noncoding RNAs Controlling Cell-Cycle Gene Expression and Proliferation in Breast Cancer Cells.
- Sun M, Gadad SS, Kim DS, Kraus WL Mol. Cell 2015 Aug 59 4 698-711
Honors & Awards
- Cecil H. and Ida Green Distinguished Chair in Reproductive Biology Sciences
- Cornell University College of Agriculture and Life Sciences Excellence in Mentoring Undergraduate Students in Independent Research Award
- Richard E. Weitzman Memorial Award from the Endocrine Society
- Distinguished Alumni Award from the Department of Molecular and Integrative Physiology, University of Illinois, Urbana-Champaign
- Cornell University College of Agriculture and Life Sciences Young Faculty Teaching Excellence Award
- Burroughs Wellcome Fund Career Award in the Biomedical Sciences, Reproductive Biology