David Chuang, Ph.D.
Professor

Graduate School

National Taiwan University (1964)

Graduate School

Utah State University (1970)

• Chaperone-mediated biogenesis of mitochondrial multi-enzyme complexes.
• Molecular genetic and biochemical basis of maple syrup urine disease.
• Structure and protein-protein interactions of mitochondrial multienzyme complexes.

Featured Publications

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure.

Sun H, Olson KC, Gao C, Prosdocimo DA, Zhou M, Wang Z, Jeyaraj D, Youn JY, Ren S, Liu Y, Rau CD, Shah S, Ilkayeva O, Gui WJ, William NS, Wynn RM, Newgard CB, Cai H, Xiao X, Chuang DT, Schulze PC, Lynch C, Jain MK, Wang Y Circulation 2016 May 133 21 2038-49

Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain a-Ketoacid Dehydrogenase Kinase.

Tso SC, Gui WJ, Wu CY, Chuang JL, Qi X, Skvorak KJ, Dorko K, Wallace AL, Morlock LK, Lee BH, Hutson SM, Strom SC, Williams NS, Tambar UK, Wynn RM, Chuang DT J. Biol. Chem. 2014 Jun

Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket.

Tso SC, Qi X, Gui WJ, Wu CY, Chuang JL, Wernstedt-Asterholm I, Morlock LK, Owens KR, Scherer PE, Williams NS, Tambar UK, Wynn RM, Chuang DT J. Biol. Chem. 2014 Feb 289 7 4432-43

Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain a-ketoacid dehydrogenase kinase.

Tso SC, Qi X, Gui WJ, Chuang JL, Morlock LK, Wallace AL, Ahmed K, Laxman S, Campeau PM, Lee BH, Hutson SM, Tu BP, Williams NS, Tambar UK, Wynn RM, Chuang DT Proc. Natl. Acad. Sci. U.S.A. 2013 May

A new locus for X-linked dominant Charcot-Marie-Tooth disease (CMTX6) is caused by mutations in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene.

Kennerson ML, Yiu EM, Chuang DT, Kidambi A, Tso SC, Ly C, Chaudhry R, Drew AP, Rance G, Delatycki MB, Züchner S, Ryan MM, Nicholson GA Hum. Mol. Genet. 2013 Jan

Phenylbutyrate therapy for maple syrup urine disease.

Brunetti-Pierri N, Lanpher B, Erez A, Ananieva EA, Islam M, Marini JC, Sun Q, Yu C, Hegde M, Li J, Wynn RM, Chuang DT, Hutson S, Lee B Hum. Mol. Genet. 2011 Feb 20 4 631-40

A synchronized substrate-gating mechanism revealed by cubic-core structure of the bovine branched-chain alpha-ketoacid dehydrogenase complex.

Kato M, Wynn RM, Chuang JL, Brautigam CA, Custorio M, Chuang DT EMBO J. 2006 Dec 25 24 5983-94

Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of the human pyruvate dehydrogenase complex.

Kato, M., Chuang, J.L., Tso, S.-C., Wynn, R.M., and Chuang, D.T. EMBO J. 2005 24 1763-1774

Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations.

Brautigam, C. A., Chuang, J. L., Tomchick, D. R., Machius, M. and Chuang, D. T. J. Mol. Biol. 2005 350 543-552

Molecular mechanism for regulation of the human mitochondrial branched-chain a-ketoacid dehydrogenase complex by phosphorylation.

Wynn, R.M., Kato, M., Machius, M., Chuang J.L., Li J, Tomchick D.R., and Chuang, D.T. Structure 2004 12 2185-2196

• VA Administration Central Ofc-Washington DC
  Associate Career Scientist Award (1988)
• VA Medical Center-Cleveland OH
  Outstanding Performance Awards (1987)
• VA Medical Center-Cleveland OH
  Outstanding Performance Awards (1986)
• VA Medical Center-Cleveland OH
  Outstanding Performance Awards (1985)

• American Association for the Advancement of Science
• American Society for Biochemistry and Molecular Biology
• American Society for Human Genetics
• Society of Chinese Bioscientists in America