Tsinghua University (1995)
Graduate School
University of Texas at Dallas (2000), Computer Sciences
Graduate School
UT Southwestern Medical Center (2002)

Research Interest

  • Our research focuses on structural and functional characterization of proteins in signal transduction. Experimental approaches include x-ray crystallography, small angle X-ray scattering, enzymology and spectroscopy.
  • The G12 class heterotrimeric G proteins and the Rho-family monomeric GTPases. We are trying to understand how these G-proteins are regulated by various protein factors, and how they interact with downstream effectors to mediate a large variety of cellular functions.
  • The pleckstrin-homology (PH) domains, with the emphasis on how these modular domains interact with proteins and lipids on membranes.


Featured Publications LegendFeatured Publications

Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated.
Melkonian KA, Ostermeyer AG, Chen JZ, Roth MG, Brown DA J. Biol. Chem. 1999 Feb 274 6 3910-7