Graduate School
Cornell University Medical Col (2006), Biochemistry

Research Interest

  • Diet-induced gene regulation and protein post-translational modification
  • Insulin cascade and mTOR pathway
  • Lipid metabolism
  • Obesity, diabetes and cardiovascular disease


Featured Publications LegendFeatured Publications

BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver.
Tian J, Wu J, Chen X, Guo T, Chen ZJ, Goldstein JL, Brown MS Elife 2018 Jun 7
Insulin induction of SREBP-1c in rodent liver requires LXRa-C/EBPß complex.
Tian J, Goldstein JL, Brown MS Proc. Natl. Acad. Sci. U.S.A. 2016 Jul 113 29 8182-7
S-nitrosylation/activation of COX-2 mediates NMDA neurotoxicity.
Tian J, Kim SF, Hester L, Snyder SH Proc. Natl. Acad. Sci. U.S.A. 2008 Jul 105 30 10537-40
The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway.
Huang Y, Kang BN, Tian J, Liu Y, Luo HR, Hester L, Snyder SH J. Neurosci. 2007 Jan 27 3 449-58
Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes.
Tian J, Bryk R, Shi S, Erdjument-Bromage H, Tempst P, Nathan C Mol. Microbiol. 2005 Aug 57 3 859-68
Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase.
Tian J, Bryk R, Itoh M, Suematsu M, Nathan C Proc. Natl. Acad. Sci. U.S.A. 2005 Jul 102 30 10670-5