Eric Berglund, Ph.D.

Eric Berglund, Ph.D., is an Assistant Professor in the Department of Internal Medicine at Ut Southwestern Medical Center and a faculty member of the Hypothalamic Research Center.

Originally from Council, Idaho, Dr. Berglund holds a bachelor's degree in biology from the University of Minnesota in Morris. He then earned a master's degree in exercise science from Miami University in Oxford, Ohio. He completed his postdoctoral degree at Vanderbilt University in Nashville. He then came to UT Southwestern as a postdoctoral fellow in the Division of Hypothalamic Research under Dr. Joel Elmquist.

Dr. Berglund's research interests include hypothalamic irregularities, glucose tolerance, glucagon, and molecular and cell metabolism. His findings are published in dozens of peer-reviewed journals, reviews, book chapters, and other media.

• Body weight control
• Central control of metabolism
• Glucagon
• Insulin sensitivity
• Leptin

Featured Publications

Ga_i/o-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents.

Yoo ES, Li L, Jia L, Lord CC, Lee CE, Birnbaum SG, Vianna CR, Berglund ED, Cunningham KA, Xu Y, Sohn JW, Liu C, Cell Rep 2021 Nov 37 7 109997

Ghrelin cell-expressed insulin receptors mediate meal- and obesity-induced declines in plasma ghrelin.

Shankar K, Takemi S, Gupta D, Varshney S, Mani BK, Osborne-Lawrence S, Metzger NP, Richard CP, Berglund ED, Zigman JM, JCI Insight 2021 Sep 6 18

Acyl-ghrelin Is Permissive for the Normal Counterregulatory Response to Insulin-Induced Hypoglycemia.

Shankar K, Gupta D, Mani BK, Findley BG, Lord CC, Osborne-Lawrence S, Metzger NP, Pietra C, Liu C, Berglund ED, Zigman JM, Diabetes 2020 02 69 2 228-237

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver.

Cappel DA, Deja S, Duarte JAG, Kucejova B, Iñigo M, Fletcher JA, Fu X, Berglund ED, Liu T, Elmquist JK, Hammer S, Mishra P, Browning JD, Burgess SC, Cell Metab 2019 06 29 6 1291-1305.e8

Celastrol Reduces Obesity in MC4R Deficiency and Stimulates Sympathetic Nerve Activity Affecting Metabolic and Cardiovascular Functions.

Saito K, Davis KC, Morgan DA, Toth BA, Jiang J, Singh U, Berglund ED, Grobe JL, Rahmouni K, Cui H, Diabetes 2019 06 68 6 1210-1220

Cytosolic Phosphoenolpyruvate Carboxykinase as a Cataplerotic Pathway in the Small Intestine.

Potts A, Uchida A, Deja S, Berglund ED, Kucejova B, Duarte JAG, Fu X, Browning JD, Magnuson MA, Burgess SC Am. J. Physiol. Gastrointest. Liver Physiol. 2018 Apr

Hypoglycemic Effect of Combined Ghrelin and Glucagon Receptor Blockade.

Mani BK, Uchida A, Lee Y, Osborne-Lawrence S, Charron MJ, Unger RH, Berglund ED, Zigman JM Diabetes 2017 May

Ire1a in Pomc Neurons is Required for Thermogenesis and Glycemia.

Yao T, Deng Z, Gao Y, Sun J, Kong X, Huang Y, He Z, Xu Y, Chang Y, Yu KJ, Findley BG, Berglund ED, Wang RT, Guo H, Chen H, Li X, Kaufman RJ, Yan J, Liu T, Williams KW Diabetes 2016 Dec

Metabolic manifestations of insulin deficiency do not occur without glucagon action.

Lee Y, Berglund ED, Wang MY, Fu X, Yu X, Charron MJ, Burgess SC, Unger RH Proc. Natl. Acad. Sci. U.S.A. 2012 Sep 109 37 14972-6

Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice.

Berglund ED, Vianna CR, Donato J, Kim MH, Chuang JC, Lee CE, Lauzon DA, Lin P, Brule LJ, Scott MM, Coppari R, Elmquist JK J. Clin. Invest. 2012 Mar 122 3 1000-9

• APS Research Recognition Award
  Annual award for Endocrinology and Metabolism Section (2006)