Dr. Berglund came to UT Southwestern after receiving his PhD from Vanderbilt University where he studied how glucagon action on the liver affects hepatic nucleotide levels as well other aspects of hepatic and whole-body metabolism. This move offered an opportunity to combine Dr. Joel Elmquist’s resources studying central regulation of metabolism and array of genetically modified mice with his expertise studying in vivo physiology. His specific areas of interest are how the hormones leptin and glucagon act in the liver and brain to control substrate metabolism and potentially energy balance. He is also interested in how CNS signals are transmitted via hormonal or neural mechanisms to modulate specific organs. These questions are relevant to diabetes and obesity. His personal interests are his family and outdoor activities.

Research Interest

  • Body weight control
  • Central control of metabolism
  • Glucagon
  • Insulin sensitivity
  • Leptin


Featured Publications LegendFeatured Publications

Metabolic manifestations of insulin deficiency do not occur without glucagon action.
Lee Y, Berglund ED, Wang MY, Fu X, Yu X, Charron MJ, Burgess SC, Unger RH Proc. Natl. Acad. Sci. U.S.A. 2012 Sep 109 37 14972-6
Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice.
Berglund ED, Vianna CR, Donato J, Kim MH, Chuang JC, Lee CE, Lauzon DA, Lin P, Brule LJ, Scott MM, Coppari R, Elmquist JK J. Clin. Invest. 2012 Mar 122 3 1000-9
Regulation of endogenous glucose production in glucose transporter 4 over-expressing mice.
Berglund ED, Li CY, Ayala JE, McGuinness OP, Wasserman DH PLoS ONE 2012 7 12 e52355
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.
Zhang Y, Xie Y, Berglund ED, Coate KC, He TT, Katafuchi T, Xiao G, Potthoff MJ, Wei W, Wan Y, Yu RT, Evans RM, Kliewer SA, Mangelsdorf DJ Elife 2012 1 e00065
Hepatic glucagon action is essential for exercise-induced reversal of mouse fatty liver.
Berglund ED, Lustig DG, Baheza RA, Hasenour CM, Lee-Young RS, Donahue EP, Lynes SE, Swift LL, Charron MJ, Damon BM, Wasserman DH Diabetes 2011 Nov 60 11 2720-9
5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver.
Xu Y, Berglund ED, Sohn JW, Holland WL, Chuang JC, Fukuda M, Rossi J, Williams KW, Jones JE, Zigman JM, Lowell BB, Scherer PE, Elmquist JK Nat. Neurosci. 2010 Dec 13 12 1457-9
Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARalpha and FGF21 transcripts in vivo.
Berglund ED, Kang L, Lee-Young RS, Hasenour CM, Lustig DG, Lynes SE, Donahue EP, Swift LL, Charron MJ, Wasserman DH Am. J. Physiol. Endocrinol. Metab. 2010 Oct 299 4 E607-14
Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity.
Berglund ED, Li CY, Bina HA, Lynes SE, Michael MD, Shanafelt AB, Kharitonenkov A, Wasserman DH Endocrinology 2009 Sep 150 9 4084-93
Hepatic energy state is regulated by glucagon receptor signaling in mice.
Berglund ED, Lee-Young RS, Lustig DG, Lynes SE, Donahue EP, Camacho RC, Meredith ME, Magnuson MA, Charron MJ, Wasserman DH J. Clin. Invest. 2009 Aug 119 8 2412-22
Glucose metabolism in vivo in four commonly used inbred mouse strains.
Berglund ED, Li CY, Poffenberger G, Ayala JE, Fueger PT, Willis SE, Jewell MM, Powers AC, Wasserman DH Diabetes 2008 Jul 57 7 1790-9

Honors & Awards

  • APS Research Recognition Award
    Annual award for Endocrinology and Metabolism Section (2006)