Jesung Moon received a B.S. from Konkuk University, Seoul, Korea with a major in Animal Sciences.  For his PhD studies, he worked with Dr. Paul Collodi at Purdue University, Indiana. His dissertation demonstrated a cell-based gene targeting system in zebrafish embryonic stem cells and explored a function of c-kit ligands for maintenance of embryonic germ cells. As a postdoctoral researcher, he accepted a joint position at the laboratory of  Drs. Lawrence Lum and James Amatruda. He focused on small molecule development and understanding of the Wnt signaling pathways in tissue regeneration. His research contributed to the development of preclinical Wnt inhibitors and revealed potential use of a Wnt inhibitor in clinical trials to treat heart disease patients.  Currently, he is interested in the development of novel small molecules to treat glioblastoma patients. In pursuit of developing therapeutics, he is investigating the molecular mechanism of ephrine receptor, a type of receptor tyrosine kinase proteins, in tumor invasion and gliogenesis and employing biomedical engineering technology, the high-throughput screening, and next-generation sequencing.


Unlisted - International Colle (1998)
Graduate School
Unlisted - International Colle (2000)
Graduate School
Purdue University Main Campus (2009)
Graduate School
Purdue University (2009), Animal Science

Research Interest

  • My primary research goals are to develop novel small molecules to attack glioblastoma and unveil the molecular mechanism of cancer invasion in the brain.


Featured Publications LegendFeatured Publications

A calcineurin-Hoxb13 axis regulates growth mode of mammalian cardiomyocytes.
Nguyen NUN, Canseco DC, Xiao F, Nakada Y, Li S, Lam NT, Muralidhar SA, Savla JJ, Hill JA, Le V, Zidan KA, El-Feky HW, Wang Z, Ahmed MS, Hubbi ME, Menendez-Montes I, Moon J, Ali SR, Le V, Villalobos E, Mohamed MS, Elhelaly WM, Thet S, Anene-Nzelu CG, Tan WLW, Foo RS, Meng X, Kanchwala M, Xing C, Roy J, Cyert MS, Rothermel BA, Sadek HA, Nature 2020 Apr
Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist.
Moon J, Zhou H, Zhang LS, Tan W, Liu Y, Zhang S, Morlock LK, Bao X, Palecek SP, Feng JQ, Williams NS, Amatruda JF, Olson EN, Bassel-Duby R, Lum L Proc. Natl. Acad. Sci. U.S.A. 2017 Feb 114 7 1649-1654
The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response.
Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Aroumougame A, Shah AM, Szweda LI, Sadek HA Cell 2014 Apr 157 3 565-79
The development of highly potent inhibitors for porcupine.
Wang X, Moon J, Dodge ME, Pan X, Zhang L, Hanson JM, Tuladhar R, Ma Z, Shi H, Williams NS, Amatruda JF, Carroll TJ, Lum L, Chen C J. Med. Chem. 2013 Mar 56 6 2700-4
Diverse Chemical Scaffolds Support Direct Inhibition of the Membrane-bound O-Acyltransferase Porcupine.
Dodge ME, Moon J, Tuladhar R, Lu J, Jacob LS, Zhang LS, Shi H, Wang X, Moro E, Mongera A, Argenton F, Karner CM, Carroll TJ, Chen C, Amatruda JF, Lum L J. Biol. Chem. 2012 Jun 287 27 23246-54


Featured Books Legend Featured Books