Jesung Moon, Ph.D. Titles and Appointments Instructor School Medical School Department Neurology Biography Jesung Moon received his bachelor’s degree in Animal Sciences from Konkuk University and Master’s degree from Seoul National University, Seoul, South Korea. He completed his Ph.D. under the mentorship of Dr. Paul Collodi at Purdue University, focusing on embryonic stem-based gene targeting and embryonic germ cells in zebrafish. Pursuing his passion for biomedical sciences, he took a postdoctoral position in the laboratory of Drs Lawrence Lum and James Amatruda, where he focused on small molecule development and the Wnt signaling pathways in cancer and tissue regeneration. His work led to the discovery of novel Wnt pathway inhibitors with potential therapeutic applications, including heart disease treatment. As an Instructor in Neurology, his research explores glioma cell migration, metastasis, and novel preclinical models for neuro-oncology. Dr. Moon has developed an in vitro system for cell migration and drug screening and identified biomarkers in leptomeningeal glioma. His goal is to advance therapeutic strategies for targeting migrating glioma cells and improving cancer treatment. Education Undergraduate Unlisted - International Colle (1998) Graduate School Unlisted - International Colle (2000) Graduate School Purdue University Main Campus (2009) Graduate School Purdue University (2009), Animal Science Research Interest Cell migration, Metastasis, Biomarker development, Drug development Publications A calcineurin–Hoxb13 axis regulates growth mode of mammalian cardiomyocytes Nguyen NU, Canseco DC, Xiao F, Nakada Y, Li S, Lam NT, Muralidhar SA, Savla JJ, Hill JA, Le V, Zidan KA, El-Feky HW, Wang Z, Ahmed MS, Hubbi ME, Menendez-Montes I, Moon J, Ali SR, Le V, Villalobos E, Mohamed MS, Elhelaly WM, Thet S, Anene-Nzelu CG, Tan WL, Foo RS, Meng X, Kanchwala M, Xing C, Roy J, Cyert MS, Rothermel BA, Sadek HA Nature 2020 Jun 582 271-276 Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist Moon J, Zhou H, Zhang LS, Tan W, Liu Y, Zhang S, Morlock LK, Bao X, Palecek SP, Feng JQ, Williams NS, Amatruda JF, Olson EN, Bassel-Duby R, Lum L Proceedings of the National Academy of Sciences of the United States of America 2017 Feb 114 1649-1654 Biochemical analysis of Tankyrase activity in zebrafish in vitro and in vivo Moon J, Amatruda JF 2016 1481 95-100 Erratum: The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response (Cell (2014) 157 (741-743)) Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Asaithamby A, Shah AM, Szweda LI, Sadek HA Cell 2014 May 157 1243 The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Aroumougame A, Shah AM, Szweda LI, Sadek HA Cell 2014 Apr 157 565-579 The development of highly potent inhibitors for porcupine Wang X, Moon J, Dodge ME, Pan X, Zhang L, Hanson JM, Tuladhar R, Ma Z, Shi H, Williams NS, Amatruda JF, Carroll TJ, Lum L, Chen C Journal of Medicinal Chemistry 2013 Mar 56 2700-2704 Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine Dodge ME, Moon J, Tuladhar R, Lu J, Jacob LS, Zhang LS, Shi H, Wang X, Moro E, Mongera A, Argenton F, Karner CM, Carroll TJ, Chen C, Amatruda JF, Lum L Journal of Biological Chemistry 2012 Jun 287 23246-23254 Zebrafish primordial germ cell cultures derived from vasa::RFP transgenic embryos Fan L, Moon J, Wong TT, Crodian J, Collodi P Stem Cells and Development 2008 Jun 17 585-597 Hypoxia-induced endothelial NO synthase gene transcriptional activation is mediated through the Tax-responsive element in endothelial cells Min J, Jin YM, Moon JS, Sung MS, Jo SA, Jo I Hypertension 2006 Jun 47 1189-1196 Interaction between - 786TC polymorphism in the endothelial nitric oxide synthase gene and smoking for myocardial infarction in Korean population Jo I, Moon J, Yoon S, Kim HT, Kim E, Park HY, Shin C, Min J, Jin YM, Cha SH, Jo SA Clinica Chimica Acta 2006 Mar 365 86-92 Results 1-10 of 15 1 2 Next Last Books Featured Books Biochemical Analysis of Tankyrase Activity in Zebrafish In Vitro and In Vivo. In Wnt Signaling Jesung Moon and James F. Amatruda. (2016). Methods Mol Biol
