Jesung Moon, Ph.D. Instructor School Medical School Department Neurology Biography Jesung Moon received a B.S. from Konkuk University, Seoul, Korea with a major in Animal Sciences. For his PhD studies, he worked with Dr. Paul Collodi at Purdue University, Indiana. His dissertation demonstrated a cell-based gene targeting system in zebrafish embryonic stem cells and explored a function of c-kit ligands for maintenance of embryonic germ cells. As a postdoctoral researcher, he accepted a joint position at the laboratory of Drs. Lawrence Lum and James Amatruda. He focused on small molecule development and understanding of the Wnt signaling pathways in tissue regeneration. His research contributed to the development of preclinical Wnt inhibitors and revealed potential use of a Wnt inhibitor in clinical trials to treat heart disease patients. Currently, he is interested in the development of novel small molecules to treat glioblastoma patients. In pursuit of developing therapeutics, he is investigating the molecular mechanism of ephrine receptor, a type of receptor tyrosine kinase proteins, in tumor invasion and gliogenesis and employing biomedical engineering technology, the high-throughput screening, and next-generation sequencing. Education Undergraduate Unlisted - International Colle (1998) Graduate School Unlisted - International Colle (2000) Graduate School Purdue University Main Campus (2009) Graduate School Purdue University (2009), Animal Science Research Interest My primary research goals are to develop novel small molecules to attack glioblastoma and unveil the molecular mechanism of cancer invasion in the brain. Publications A calcineurin–Hoxb13 axis regulates growth mode of mammalian cardiomyocytes Nguyen NU, Canseco DC, Xiao F, Nakada Y, Li S, Lam NT, Muralidhar SA, Savla JJ, Hill JA, Le V, Zidan KA, El-Feky HW, Wang Z, Ahmed MS, Hubbi ME, Menendez-Montes I, Moon J, Ali SR, Le V, Villalobos E, Mohamed MS, Elhelaly WM, Thet S, Anene-Nzelu CG, Tan WL, Foo RS, Meng X, Kanchwala M, Xing C, Roy J, Cyert MS, Rothermel BA, Sadek HA Nature 2020 Jun 582 271-276 Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist Moon J, Zhou H, Zhang LS, Tan W, Liu Y, Zhang S, Morlock LK, Bao X, Palecek SP, Feng JQ, Williams NS, Amatruda JF, Olson EN, Bassel-Duby R, Lum L Proceedings of the National Academy of Sciences of the United States of America 2017 Feb 114 1649-1654 Biochemical analysis of Tankyrase activity in zebrafish in vitro and in vivo Moon J, Amatruda JF 2016 1481 95-100 Erratum: The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response (Cell (2014) 157 (741-743)) Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Asaithamby A, Shah AM, Szweda LI, Sadek HA Cell 2014 May 157 1243 The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Aroumougame A, Shah AM, Szweda LI, Sadek HA Cell 2014 Apr 157 565-579 The development of highly potent inhibitors for porcupine Wang X, Moon J, Dodge ME, Pan X, Zhang L, Hanson JM, Tuladhar R, Ma Z, Shi H, Williams NS, Amatruda JF, Carroll TJ, Lum L, Chen C Journal of Medicinal Chemistry 2013 Mar 56 2700-2704 Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine Dodge ME, Moon J, Tuladhar R, Lu J, Jacob LS, Zhang LS, Shi H, Wang X, Moro E, Mongera A, Argenton F, Karner CM, Carroll TJ, Chen C, Amatruda JF, Lum L Journal of Biological Chemistry 2012 Jun 287 23246-23254 Zebrafish primordial germ cell cultures derived from vasa::RFP transgenic embryos Fan L, Moon J, Wong TT, Crodian J, Collodi P Stem Cells and Development 2008 Jun 17 585-597 Hypoxia-induced endothelial NO synthase gene transcriptional activation is mediated through the Tax-responsive element in endothelial cells Min J, Jin YM, Moon JS, Sung MS, Jo SA, Jo I Hypertension 2006 Jun 47 1189-1196 Interaction between - 786TC polymorphism in the endothelial nitric oxide synthase gene and smoking for myocardial infarction in Korean population Jo I, Moon J, Yoon S, Kim HT, Kim E, Park HY, Shin C, Min J, Jin YM, Cha SH, Jo SA Clinica Chimica Acta 2006 Mar 365 86-92 Results 1-10 of 15 1 2 Next Last Books Featured Books Biochemical Analysis of Tankyrase Activity in Zebrafish In Vitro and In Vivo. In Wnt Signaling Jesung Moon and James F. Amatruda. (2016). Methods Mol Biol
