Diego Castrillon, M.D., Ph.D. Professor Endowed Title Vernie A. Stembridge, M.D., Distinguished Chair in Pathology School Medical School Department Pathology | Obstetrics and Gynecology Graduate Programs Cancer Biology You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Diego H. Castrillon is a Professor of Pathology. Dr. Castrillon obtained his S.B. in Life Sciences from M.I.T. (1987) and his M.D., Ph.D. degrees from UT Southwestern (1996). He completed a residency in Surgical Pathology and a clinical fellowship in Obstetric and Gynecologic Pathology at the Brigham & Women's Hospital / Harvard Medical School, and a postdoctoral research fellowship in Cancer Genetics at the Dana Farber Cancer Institute. The Castrillon laboratory is devoted to the study of gynecologic malignancies, with a main focus on uterine (endometrial) cancer, and has developed a number of new approaches and model systems for this common malignancy of women. An improved understanding of this understudied disease will lead to improved diagnostic methods and therapeutic approaches. Dr. Castrillon is board-certified in Anatomic Pathology and serves on the Obstetric and Gynecologic Pathology Service at UT Southwestern. Education Graduate School UT Southwestern Medical Center (1994), Genetics & Development Other Post Graduate Training UT Southwestern Medical Center (1994) Medical School UT Southwestern Medical Center (1996) Residency Harvard Medical School/Brigham & Women's Hospital (1999), Anatomic Pathology Fellowship Harvard Medical School/Brigham & Women's Hospital (2000), Gynecologic Pathology Research Interest Endometrial Cancer Gynecologic Pathology POLE-mediated ultramutation Publications Featured Publications FOXA2 suppresses endometrial carcinogenesis and epithelial-mesenchymal transition by regulating enhancer activity. Sahoo SS, Ramanand SG, Gao Y, Abbas A, Kumar A, Cuevas IC, Li HD, Aguilar M, Xing C, Mani RS, Castrillon DH, J Clin Invest 2022 Jun 132 12 Histopathologic diagnosis of endometrial precancers: Updates and future directions. Chen H, Strickland AL, Castrillon DH, Semin Diagn Pathol 2021 Dec Reliable Identification of Endometrial Precancers Through Combined Pax2, ?-Catenin, and Pten Immunohistochemistry. Aguilar M, Chen H, Rivera-Colon G, Niu S, Carrick K, Gwin K, Cuevas IC, Sahoo SS, Li HD, Zhang S, Zheng W, Lucas E, Castrillon DH, Am J Surg Pathol 2021 Sep Serial genomic analysis of endometrium supports the existence of histologically indistinct endometrial cancer precursors. Aguilar M, Zhang H, Zhang M, Cantarell B, Sahoo SS, Li HD, Cuevas IC, Lea J, Miller DS, Chen H, Zheng W, Gagan J, Lucas E, Castrillon DH, J Pathol 2021 Jan A PoleP286R mouse model of endometrial cancer recapitulates high mutational burden and immunotherapy response. Li HD, Lu C, Zhang H, Hu Q, Zhang J, Cuevas IC, Sahoo SS, Aguilar M, Maurais EG, Zhang S, Wang X, Akbay EA, Li GM, Li B, Koduru P, Ly P, Fu YX, Castrillon DH, JCI Insight 2020 Jul 5 14 Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition. Cuevas IC, Sahoo SS, Kumar A, Zhang H, Westcott J, Aguilar M, Cortez JD, Sullivan SA, Xing C, Hayes DN, Brekken RA, Bae-Jump VL, Castrillon DH, Proc. Natl. Acad. Sci. U.S.A. 2019 Nov Polymerase-mediated ultramutagenesis in mice produces diverse cancers with high mutational load. Li HD, Cuevas I, Zhang M, Lu C, Alam MM, Fu YX, You MJ, Akbay EA, Zhang H, Castrillon DH J. Clin. Invest. 2018 Aug 128 9 4179-4191 Somatic LKB1 mutations promote cervical cancer progression. Wingo SN, Gallardo TD, Akbay EA, Liang MC, Contreras CM, Boren T, Shimamura T, Miller DS, Sharpless NE, Bardeesy N, Kwiatkowski DJ, Schorge JO, Wong KK, Castrillon DH PLoS ONE 2009 4 4 e5137 FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR, Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, DePinho RA Cell 2007 Jan 128 2 309-23 PI3K Pathway Effectors pAKT and FOXO1 as Novel Markers of Endometrioid Intraepithelial Neoplasia. Strickland AL, Rivera G, Lucas E, John G, Cuevas I, Castrillon DH Int. J. Gynecol. Pathol. 2018 Sep Results 1-10 of 14 1 2 Next Last Books Featured Books Development and Maldevelopment of the Female Reproductive System. In Gynecologic and Obstetric Pathology (editors: W. Zheng et al) Diego H. Castrillon (2019). Springer Honors & Awards American Association for the Advancement of Science (AAAS)Elected Fellow, Section on Medical Sciences (2022) International Society of Gynecologic PathologistsInducted (2017) American Society for Clinical InvestigationElected Member (2009) National Institutes of HealthMouse Pathobiologist Award (2007) Kimmel Scholar Award in Translational ScienceSidney Kimmel Foundation for Cancer Research (2004) Damon Runyon Postdoctoral FellowshipDamon Runyon Cancer Research Foundation (2000) Stanley L. Robbins Research AwardBrigham & Women Hospital / Harvard Medical School (1999) Professional Associations/Affiliations American Association for Cancer Research (2004) American Society for Clinical Investigation (2009) European Society of Gynaecological Oncology (2016) International Society of Gynecologic Pathologists (2017) United States and Canadian Academy of Pathology (2012)
