Uttam Tambar, Ph.D.

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Uttam K. Tambar moved from India to the United States in 1982. He received his A.B. degree from Harvard University in 2000 and his Ph.D. from the California Institute of Technology in 2006 with Professor Brian Stoltz. After he completed his NIH Postdoctoral Fellowship at Columbia University with Professor James Leighton in 2009, he began his independent research career at UT Southwestern Medical Center in Dallas. He is currently an Associate Professor in the Biochemistry Department and a W. W. Caruth, Jr. Scholar in Biomedical Research. The Tambar lab is interested in asymmetric catalysis, natural product synthesis, and medicinal chemistry.

Dr. Tambar is interested in developing new strategies and concepts in synthetic chemistry to address challenging problems in biomedical research. In addition to making fundamental advances in chemistry, he will take advantage of the unique opportunities for collaborative research at UT Southwestern.

Twitter: @TambarLab

Graduate School

Harvard University (2000), Chemistry

Graduate School

California Inst of Technology (2006), Organic Chemistry

• Development of new chemical reactions
• Discovery of small molecule drugs
• Synthesis of complex biologically active natural products

Featured Publications

Photocatalyzed Diastereoselective Isomerization of Cinnamyl Chlorides to Cyclopropanes.

Xu B, Troian-Gautier L, Dykstra R, Martin RT, Gutierrez O, Tambar UK, J. Am. Chem. Soc. 2020 Apr 142 13 6206-6215

Total Synthesis of (+)-Rubellin C

Jackson A. Gartman and Uttam K. Tambar Org. Lett. 2020

N-Heterocyclic Carbene Based Catalytic Platform for Hauser-Kraus Annulations

Mohammed Sharique and Uttam K. Tambar Chem. Sci. 2020 11 7239?7243

Controllable, Sequential, and Stereoselective C-H Allylic Alkylation of Alkenes.

Qin L, Sharique M, Tambar UK, J. Am. Chem. Soc. 2019 10 141 43 17305-17313

Remote Allylation of Unactivated C(sp3)-H Bonds Triggered by Photogenerated Amidyl Radicals

. Bin Xu and Uttam K. Tambar ACS Catal. 2019 9 4627-4631

Development of the Vinylogous Pictet-Spengler Cyclization and Total Synthesis of (±)-Lundurine A

Aaron Nash, Xiangbing Qi, Pradip Maity, Kyle Owens, and Uttam K. Tambar Angew. Chem. Int. Ed. 2018 57 6888-6891

Copper-catalyzed [1,2]-rearrangements of allylic iodides and aryl a-diazoacetates.

Xu B, Gartman J, Tambar UK Tetrahedron 2017 Jul 73 29 4150-4159

Catalytic allylic oxidation of internal alkenes to a multifunctional chiral building block.

Bayeh L, Le PQ, Tambar UK Nature 2017 Jun

Copper-Catalyzed Enantioselective, Diastereoselective, and Regioselective [2,3]-Rearrangements of Iodonium Ylides.

Xu B, Tambar UK Angew. Chem. Int. Ed. Engl. 2017 Jun

Copper-Catalyzed Aminothiolation of 1,3-Dienes via a Dihydrothiazine Intermediate.

Sleet CE, Tambar UK Angew. Chem. Int. Ed. Engl. 2017 Apr

 Featured Books

[2,3]-Rearrangements of Ammonium Zwitterions. In Molecular Rearrangements in Organic Synthesis

Hongli Bao and Uttam K. Tambar (2016). New Jersey, USA, John Wiley & Sons

Synthesis of Amines by Rearrangements. 2020, 2, 315.. In Science of Synthesis Knowledge Updates

Charles Ochoa and Uttam K. Tambar (2020).

. Chapter 6 - Synthesis of (±)-Amathaspiramide F: Stereochemical Switch of a [2,3]-Stevens Rearrangement. 2014,10, 131-154.. In Strategies and Tactics in Organic Synthesis

Arash Soheili, Carrie Johnson, and Uttam K. Tambar (2014).

• Dallas Tiki Week Home Bartender Tiki Cocktail Winner
  (2019)
• Welch Foundation Norman Hackerman Award In Chemical Research
  (2019)
• Chair of the Chemistry and Cancer Program, Simmons Comprehensive Cancer Center
  (2018)
• Sloan Foundation Research Fellowship
  (2013)
• W. W. Caruth, Jr. Scholar in Biomedical Research
  (2009)
• NIH Ruth L. Kirschstein NRSA Postdoctoral Fellow
  (2006)
• National Defense Science and Engineering Graduate Fellow
  (2001)
• John Harvard Scholar
  (1999)

• American Chemical Society (2000)