Yuanyuan “Faith” Zhang, M.D., Ph.D. Assistant Professor School Medical School Department Radiation Oncology Graduate Programs Genetics, Development and Disease You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Yuanyuan “Faith” Zhang, M.D., Ph.D., is an Assistant Professor of Radiation Oncology at UT Southwestern Medical Center specializing in the treatment of lung cancer. She earned both her medical degree and Ph.D. from UT Southwestern Medical Center and completed a transitional year program at Memorial Sloan Kettering Cancer Center. Her radiation oncology residency training was completed at UT Southwestern. As the principal investigator of the Zhang (Faith) Lab, Dr. Zhang's research focuses on leveraging the microenvironmental immunometabolism to enhance the efficacy of radiation therapy. Her work encompasses basic science, preclinical studies, and clinical trials, all aimed at improving patient outcomes through personalized radiotherapy. Dr. Zhang offers advanced treatment options such as SCINTIX® biology-guided radiation therapy, adaptive radiotherapy guided by CT and MRI, and personalized ultrafractionated stereotactic adaptive radiotherapy (PULSAR®). Dr. Zhang is an active member of several professional societies, including the American Society for Radiation Oncology (ASTRO), the American Society for Clinical Oncology (ASCO), the American Association for Cancer Research (AACR), and the Radiological Society of North America (RSNA). She has also received numerous accolades, including the ASCO Young Investigator Award, the Clinical and Translational Research Scholar (KL2) Award, the Distinguished Researcher Award from the President’s Research Council, the American Cancer Society Award, and the NCI-UTSW Lung SPORES Career Enhancement Award. Education Other Post Graduate Training UT Southwestern Medical School (2016) Graduate School UT Southwestern Medical School (2016), Medical Sciences Medical School UT Southwestern Medical School (2016) Internship Memorial Sloan-Kettering Cancer Center (2017), Transitional Year Residency UT Southwestern Medical Center (2021), Radiation Oncology Research Interest Cancer metabolism Immunotherapy Personalized ultrafractionated stereotactic adaptive radiotherapy (PULSAR) Radiobiology Publications Adapt-On-Demand: A Novel Strategy for Personalized Adaptive Radiation Therapy for Locally Advanced Lung Cancer Li R, Zhuang T, Montalvo S, Wang K, Parsons D, Zhang Y, Iyengar P, Wang J, Godley A, Cai B, Lin MH, Westover K Practical Radiation Oncology 2024 Sep 14 e395-e406 Beyond conventional bounds: Surpassing system limits for stereotactic ablative (SAbR) lung radiotherapy using CBCT-based adaptive planning system Gonzalez Y, Visak J, Overman L, Liao CY, Yen A, Zhuang T, Cai B, Godley A, Zhang Y, Timmerman R, Iyengar P, Westover K, Parsons D, Lin MH Journal of applied clinical medical physics 2024 Aug 25 An AI-based approach for modeling the synergy between radiotherapy and immunotherapy Peng H, Moore C, Zhang Y, Saha D, Jiang S, Timmerman R Scientific reports 2024 Apr 14 8250 Systemic immune parameters after prior radiation therapy in patients receiving immune checkpoint inhibitors Mundra V, Yang Y, von Itzstein MS, Fattah F, Gonugunta AS, Hannan R, Pop LM, Zhang Y, Wang Y, Sheffield T, Xie Y, Dowell JE, Homsi J, Rashdan S, Park J, Li Q, Wakeland EK, Gerber DE Translational Oncology 2023 Aug 34 DNA-PKcs and ATM modulate mitochondrial ADP-ATP exchange as an oxidative stress checkpoint mechanism Chen WM, Chiang JC, Shang Z, Palchik G, Newman C, Zhang Y, Davis AJ, Lee H, Chen PB EMBO Journal 2023 Mar 42 In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma Kaushik AK, Tarangelo A, Boroughs LK, Ragavan M, Zhang Y, Wu CY, Li X, Ahumada K, Chiang JC, Tcheuyap VT, Saatchi F, Do QN, Yong C, Rosales T, Stevens C, Rao AD, Faubert B, Pachnis P, Zacharias LG, Vu H, Cai F, Mathews TP, Genovese G, Slusher BS, Kapur P, Sun X, Merritt ME, Brugarolas J, DeBerardinis RJ Science Advances 2022 8 Stereotactic Ablative Radiation Therapy for Oligoprogressive Renal Cell Carcinoma Schoenhals JE, Mohamad O, Christie A, Zhang Y, Li D, Singla N, Bowman I, Arafat W, Hammers H, Courtney K, Cole S, Bagrodia A, Margulis V, Desai N, Garant A, Choy H, Timmerman R, Brugarolas J, Hannan R Advances in Radiation Oncology 2021 Sep 6 Cosmetic Outcomes of a Phase 1 Dose Escalation Study of 5-Fraction Stereotactic Partial Breast Irradiation for Early Stage Breast Cancer Rahimi A, Morgan HE, Kim DW, Zhang Y, Leitch M, Wooldridge RD, Goudreau S, Haley BB, Rao R, Rivers A, Spangler AE, Jones RT, Stevenson S, Staley J, Albuquerque K, Ahn C, Neufeld S, Alluri PG, Ding C, Garwood D, Seiler S, Zhao B, Gu X, Timmerman R International Journal of Radiation Oncology Biology Physics 2021 Jul 110 772-782 Risk Factors for Fat Necrosis After Stereotactic Partial Breast Irradiation for Early-Stage Breast Cancer in a Phase 1 Clinical Trial Rahimi A, Zhang Y, Kim DW, Morgan H, Hossain F, Leitch M, Wooldridge RD, Seiler S, Goudreau S, Haley BB, Rao R, Rivers A, Spangler AE, Ahn C, Stevenson S, Staley J, Albuquerque K, Ding C, Gu X, Zhao B, Timmerman R International Journal of Radiation Oncology Biology Physics 2020 Nov 108 697-706 Stereotactic Ablative Radiation Therapy (SAbR) Used to Defer Systemic Therapy in Oligometastatic Renal Cell Cancer Zhang Y, Schoenhals J, Christie A, Mohamad O, Wang C, Bowman I, Singla N, Hammers H, Courtney K, Bagrodia A, Margulis V, Desai N, Garant A, Choy H, Timmerman R, Brugarolas J, Hannan R International Journal of Radiation Oncology Biology Physics 2019 Oct 105 367-375 Results 1-10 of 18 1 2 Next Last Honors & Awards American Cancer Society - Institutional Research Grant (ACS-IRG) Award (2024) Forbeck Foundation Research Scholar Award (2023) Clinical and Translational Science Pilot Grant (2022) Clinical and Translational Science Pilot Grant (2022) Distinguished Researcher Award from the President Research Council (2022) Lung SPORES Career Enhancement Award (2022) ASCO Young Investigator Award (2021) Clinical and Translational Research Scholar (KL2) Award (2021-2023) Finalist for J. Mitchell, George and Stephen Brown Award for Resident Excellence in Radiation Oncology (2021) Roentgen Resident/Fellow Research Award (2021) Radiation Oncology Early Career Development Award (2020) Holman Research Fellow (2018-2020) Gold Humanism Honors Society (2015) The 29th Annual Ida M Green Award (2015) Christine Wilson Award for Outstanding Student Research (2007) Merrill Presidential Scholar (2007) Professional Associations/Affiliations American Association for Cancer Research (AACR) (2020) American Board of Radiology B. Leonard Holman Research Pathway (2011-2012) American Physician Scientists Association (APSA) (2009-2016) American Society for Radiation Oncology (ASTRO) (2017) American Society of Clinical Oncology (ASCO) (2018) Association of Residents in Radiation Oncology (ARRO) (2016-2021) Association of Residents in Radiation Oncology (ARRO) Global Health Subcommittee (2018-2019) Chinese American Hematologist and Oncologist Network (CAHON) (2021-2023) Cornell Health International (2005-2007) Radiation Research Society (RRS) (2022-2024) Radiological Society of North America (RSNA) (2018) Society of Women in Radiation Oncology (SWRO) (2020-2023) Students Emerging Academy of Leaders (SEALs) at UTSW (2013-2015) Women in Science and Medicine (WISMAC) at UTSW (2009-2016)
