Dr. Matthias Wolf is a Pediatric Nephrologist at UT Southwestern and Children’s Medical Center Dallas. He was born in Germany and attended Medical School at the Johannes Gutenberg University in Mainz, where he obtained his doctoral degree. Dr. Wolf finished his medical studies at the Ludwig-Maximilians University in Munich, Germany. He completed his five-year residency program at different academic centers in Germany, including the University Children’s Hospitals in Erlangen-Nuremberg, Berlin and Cologne. He interrupted his training for two years of postdoctoral fellowship training at the University of Michigan. Here, he studied the genetics of inherited kidney disorders, including different forms of cystic kidney disease and nephrotic syndrome. After his return to Germany, he passed the German Pediatric Board exam, and became one of the youngest assistant professors at the University Children’s Hospital in Cologne. In 2006, he returned to the United States and completed pediatric residency training at Children’s Medical Center in Dallas. He continued as a fellow in the Pediatric Nephrology program at UT Southwestern, which he successfully completed in 2012. During his fellowship training, Dr. Wolf joined Dr. Huang’s laboratory at UT Southwestern, where he learned patch-clamp recording, protein biochemistry, and mouse genetics. Dr. Wolf joined the faculty after graduating from fellowship. He has a strong interest in clinical aspects of renal channelopathies, magnesium and calcium homeostasis, inherited kidney diseases, cystic kidney disease, nephrotic syndrome, and nephrolithiasis. Dr. Wolf is a member of the editorial board of Pediatric Nephrology. In his laboratory, Dr. Wolf focuses on regulation of TRP (transient receptor potential) channels. He studies the regulation of TRP channels by urinary proteins and how this process contributes to common disorders such as kidney stones or type 2 diabetes mellitus. Dr. Wolf received the Carl W. Gottschalk Research Scholar grant from the American Society of Nephrology. His scientific contribution resulted in over 34 peer-reviewed publications and seven book chapters and reviews. He is currently supported by a NIH Career Development Award and funding by the Children’s Clinical Research Advisory Committee (CCRAC).


Medical School
Johannes Gutenberg University Mainz (1999)
Ludwig-Maximilians-Universitat Munich (1999), Internal Medicine
University Children's Hospital Erlangen-Nuremberg (2000), Pediatrics
Benjamin Franklin Childrens Hospital (2001), Pediatrics
University Children's Hospital, Freiburg Germany (2002), Pediatrics
University of Michigan Hospitals & Health Centers (2004), Research
University Children's Hospital, Charite, Berlin (2004), Neonatal-perinatal Medicine
University Children's Hospital Cologne Germany (2006), Pediatrics
University of Michigan Hospitals & Health Centers (2007), Research
UT Southwestern/Children's Medical Center (2009), Pediatrics
UT Southwestern/Children's Medical Center (2012), Pediatric Nephrology


Featured Publications LegendFeatured Publications

The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome.
Delous M, Baala L, Salomon R, Laclef C, Vierkotten J, Tory K, Golzio C, Lacoste T, Besse L, Ozilou C, Moutkine I, Hellman NE, Anselme I, Silbermann F, Vesque C, Gerhardt C, Rattenberry E, Wolf MT, Gubler MC, Martinovic J, Encha-Razavi F, Boddaert N, Gonzales M, Macher MA, Nivet H, Champion G, Berthélémé JP, Niaudet P, McDonald F, Hildebrandt F, Johnson CA, Vekemans M, Antignac C, Rüther U, Schneider-Maunoury S, Attié-Bitach T, Saunier S Nat. Genet. 2007 Jul 39 7 875-81
Medullary cystic kidney disease type 1: mutational analysis in 37 genes based on haplotype sharing.
Wolf MT, Mucha BE, Hennies HC, Attanasio M, Panther F, Zalewski I, Karle SM, Otto EA, Deltas CC, Fuchshuber A, Hildebrandt F Hum. Genet. 2006 Jul 119 6 649-58
Mapping a new suggestive gene locus for autosomal dominant nephrolithiasis to chromosome 9q33.2-q34.2 by total genome search for linkage.
Wolf MT, Zalewski I, Martin FC, Ruf R, Müller D, Hennies HC, Schwarz S, Panther F, Attanasio M, Acosta HG, Imm A, Lucke B, Utsch B, Otto E, Nurnberg P, Nieto VG, Hildebrandt F Nephrol. Dial. Transplant. 2005 May 20 5 909-14
Expression and phenotype analysis of the nephrocystin-1 and nephrocystin-4 homologs in Caenorhabditis elegans.
Wolf MT, Lee J, Panther F, Otto EA, Guan KL, Hildebrandt F J. Am. Soc. Nephrol. 2005 Mar 16 3 676-87
Telomeric refinement of the MCKD1 locus on chromosome 1q21.
Wolf MT, van Vlem B, Hennies HC, Zalewski I, Karle SM, Puetz M, Panther F, Otto E, Fuchshuber A, Lameire N, Loeys B, Hildebrandt F Kidney Int. 2004 Aug 66 2 580-5
Mutations of the Uromodulin gene in MCKD type 2 patients cluster in exon 4, which encodes three EGF-like domains.
Wolf MT, Mucha BE, Attanasio M, Zalewski I, Karle SM, Neumann HP, Rahman N, Bader B, Baldamus CA, Otto E, Witzgall R, Fuchshuber A, Hildebrandt F Kidney Int. 2003 Nov 64 5 1580-7
Refinement of the critical region for MCKD1 by detection of transcontinental haplotype sharing.
Wolf MT, Karle SM, Schwarz S, Anlauf M, Anlauf M, Glaeser L, Kroiss S, Burton C, Feest T, Otto E, Fuchshuber A, Hildebrandt F Kidney Int. 2003 Sep 64 3 788-92
Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis.
Olbrich H, Fliegauf M, Hoefele J, Kispert A, Otto E, Volz A, Wolf MT, Sasmaz G, Trauer U, Reinhardt R, Sudbrak R, Antignac C, Gretz N, Walz G, Schermer B, Benzing T, Hildebrandt F, Omran H Nat. Genet. 2003 Aug 34 4 455-9
Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination.
Otto EA, Schermer B, Obara T, O'Toole JF, Hiller KS, Mueller AM, Ruf RG, Hoefele J, Beekmann F, Landau D, Foreman JW, Goodship JA, Strachan T, Kispert A, Wolf MT, Gagnadoux MF, Nivet H, Antignac C, Walz G, Drummond IA, Benzing T, Hildebrandt F Nat. Genet. 2003 Aug 34 4 413-20
A gene locus for steroid-resistant nephrotic syndrome with deafness maps to chromosome 14q24.2.
Ruf RG, Wolf MT, Hennies HC, Lucke B, Zinn C, Varnholt V, Lichtenberger A, Pasch A, Imm A, Briese S, Lennert T, Fuchshuber A, Nurnberg P, Hildebrandt F J. Am. Soc. Nephrol. 2003 Jun 14 6 1519-22


Featured Books Legend Featured Books

Honors & Awards

  • Best Pediatric Specialists/Doctors in Dallas
    D Magazine (2018)
  • Editorial Board
    Pediatric Nephrology (2018)
  • Junior Investigator Research Award, Children’s Clinical Research Advisory Committee
    Children's Medical Center Dallas (2016)
  • Carl W. Gottschalk Research Scholar Grant
    American Society of Nephrology (2014)
  • Junior Investigator Research Award, Children’s Clinical Research Advisory Committee
    Children's Medical Center Dallas (2013)
  • Awarded Best Oral Presentation, Third Annual Senior Fellows' Research Day
    UT Southwestern Medical Center (2012)
  • Pediatric Resident Research Award
    UT Southwestern Medical Center (2007-2009)

Professional Associations/Affiliations

  • American Diabetes Association (2018)
  • American Physiological Society (2015)
  • International Pediatric Nephrology Association (2014)
  • American Board of Pediatrics, Diplomate (2010)
  • American Society for Nephrology (2009)
  • American Medical Association (2008)
  • American Academy of Pediatrics (2007)
  • Society for Pediatric Nephrology, Germany (2004)
  • German Society of Pediatrics (1999)