Dr. Matthias Wolf is a Pediatric Nephrologist at UT Southwestern and Children’s Medical Center Dallas. He was born in Germany and attended Medical School at the Johannes Gutenberg University in Mainz, where he obtained his doctoral degree. Dr. Wolf finished his medical studies at the Ludwig-Maximilians University in Munich, Germany. He completed his five-year residency program at different academic centers in Germany, including the University Children’s Hospitals in Erlangen-Nuremberg, Berlin and Cologne. He interrupted his training for two years of postdoctoral fellowship training at the University of Michigan. Here, he studied the genetics of inherited kidney disorders, including different forms of cystic kidney disease and nephrotic syndrome. After his return to Germany, he passed the German Pediatric Board exam, and became one of the youngest assistant professors at the University Children’s Hospital in Cologne. In 2006, he returned to the United States and completed pediatric residency training at Children’s Medical Center in Dallas. He continued as a fellow in the Pediatric Nephrology program at UT Southwestern, which he successfully completed in 2012. During his fellowship training, Dr. Wolf joined Dr. Huang’s laboratory at UT Southwestern, where he learned patch-clamp recording, protein biochemistry, and mouse genetics. Dr. Wolf joined the faculty after graduating from fellowship. He has a strong interest in clinical aspects of renal channelopathies, magnesium and calcium homeostasis, inherited kidney diseases, cystic kidney disease, nephrotic syndrome, and nephrolithiasis. Dr. Wolf is a member of the editorial board of Pediatric Nephrology. In his laboratory, Dr. Wolf focuses on regulation of TRP (transient receptor potential) channels. He studies the regulation of TRP channels by urinary proteins and how this process contributes to common disorders such as kidney stones or type 2 diabetes mellitus. Dr. Wolf received the Carl W. Gottschalk Research Scholar grant from the American Society of Nephrology. His scientific contribution resulted in over 34 peer-reviewed publications and seven book chapters and reviews. He is currently supported by a NIH Career Development Award and funding by the Children’s Clinical Research Advisory Committee (CCRAC).


Medical School
Johannes Gutenberg University Mainz (1999)
Ludwig-Maximilians-Universitat Munich (1999), Internal Medicine
University Children's Hospital Erlangen-Nuremberg (2000), Pediatrics
Benjamin Franklin Childrens Hospital (2001), Pediatrics
University Children's Hospital, Freiburg Germany (2002), Pediatrics
University of Michigan Hospitals & Health Centers (2004), Research
University Children's Hospital, Charite, Berlin (2004), Neonatal-perinatal Medicine
University Children's Hospital Cologne Germany (2006), Pediatrics
University of Michigan Hospitals & Health Centers (2007), Research
UT Southwestern/Children's Medical Center (2009), Pediatrics
UT Southwestern/Children's Medical Center (2012), Pediatric Nephrology


Featured Publications LegendFeatured Publications

Uromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosis.
Wolf MT, Wu XR, Huang CL Kidney Int. 2013 Mar
Autosomal dominant mutation in the signal peptide of renin in a kindred with anemia, hyperuricemia, and CKD.
Beck BB, Trachtman H, Gitman M, Miller I, Sayer JA, Pannes A, Baasner A, Hildebrandt F, Wolf MT Am. J. Kidney Dis. 2011 Nov 58 5 821-5
Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy.
Otto EA, Ramaswami G, Janssen S, Chaki M, Allen SJ, Zhou W, Airik R, Hurd TW, Ghosh AK, Wolf MT, Hoppe B, Neuhaus TJ, Bockenhauer D, Milford DV, Soliman NA, Antignac C, Saunier S, Johnson CA, Hildebrandt F J. Med. Genet. 2011 Feb 48 2 105-16
Wolf MT, Hildebrandt F Pediatr. Nephrol. 2011 Feb 26 2 181-94
Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expression.
Zaucke F, Boehnlein JM, Steffens S, Polishchuk RS, Rampoldi L, Fischer A, Pasch A, Boehm CW, Baasner A, Attanasio M, Hoppe B, Hopfer H, Beck BB, Sayer JA, Hildebrandt F, Wolf MT Hum. Mol. Genet. 2010 May 19 10 1985-97
Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy.
O'Toole JF, Liu Y, Davis EE, Westlake CJ, Attanasio M, Otto EA, Seelow D, Nurnberg G, Becker C, Nuutinen M, Kärppä M, Ignatius J, Uusimaa J, Pakanen S, Jaakkola E, van den Heuvel LP, Fehrenbach H, Wiggins R, Goyal M, Zhou W, Wolf MT, Wise E, Helou J, Allen SJ, Murga-Zamalloa CA, Ashraf S, Chaki M, Heeringa S, Chernin G, Hoskins BE, Chaib H, Gleeson J, Kusakabe T, Suzuki T, Isaac RE, Quarmby LM, Tennant B, Fujioka H, Tuominen H, Hassinen I, Lohi H, van Houten JL, Rotig A, Sayer JA, Rolinski B, Freisinger P, Madhavan SM, Herzer M, Madignier F, Prokisch H, Nurnberg P, Jackson PK, Jackson P, Khanna H, Katsanis N, Hildebrandt F J. Clin. Invest. 2010 Mar 120 3 791-802
Mutation analysis of the Uromodulin gene in 96 individuals with urinary tract anomalies (CAKUT).
Wolf MT, Hoskins BE, Beck BB, Hoppe B, Tasic V, Otto EA, Hildebrandt F Pediatr. Nephrol. 2009 Jan 24 1 55-60
A systematic approach to mapping recessive disease genes in individuals from outbred populations.
Hildebrandt F, Heeringa SF, Rüschendorf F, Attanasio M, Nürnberg G, Becker C, Seelow D, Huebner N, Chernin G, Vlangos CN, Zhou W, O'Toole JF, Hoskins BE, Wolf MT, Hinkes BG, Chaib H, Ashraf S, Schoeb DS, Ovunc B, Allen SJ, Vega-Warner V, Wise E, Harville HM, Lyons RH, Washburn J, Macdonald J, Nürnberg P, Otto EA PLoS Genet. 2009 Jan 5 1 e1000353
Mutation analysis in nephronophthisis using a combined approach of homozygosity mapping, CEL I endonuclease cleavage, and direct sequencing.
Otto EA, Helou J, Allen SJ, O'Toole JF, Wise EL, Ashraf S, Attanasio M, Zhou W, Wolf MT, Hildebrandt F Hum. Mutat. 2008 Mar 29 3 418-26
Evidence of oligogenic inheritance in nephronophthisis.
Hoefele J, Wolf MT, O'Toole JF, Otto EA, Schultheiss U, Dêschenes G, Attanasio M, Utsch B, Antignac C, Hildebrandt F J. Am. Soc. Nephrol. 2007 Oct 18 10 2789-95


Featured Books Legend Featured Books

Honors & Awards

  • Best Pediatric Specialists/Doctors in Dallas
    D Magazine (2018)
  • Editorial Board
    Pediatric Nephrology (2018)
  • Junior Investigator Research Award, Children’s Clinical Research Advisory Committee
    Children's Medical Center Dallas (2016)
  • Carl W. Gottschalk Research Scholar Grant
    American Society of Nephrology (2014)
  • Junior Investigator Research Award, Children’s Clinical Research Advisory Committee
    Children's Medical Center Dallas (2013)
  • Awarded Best Oral Presentation, Third Annual Senior Fellows' Research Day
    UT Southwestern Medical Center (2012)
  • Pediatric Resident Research Award
    UT Southwestern Medical Center (2007-2009)

Professional Associations/Affiliations

  • American Diabetes Association (2018)
  • American Physiological Society (2015)
  • International Pediatric Nephrology Association (2014)
  • American Board of Pediatrics, Diplomate (2010)
  • American Society for Nephrology (2009)
  • American Medical Association (2008)
  • American Academy of Pediatrics (2007)
  • Society for Pediatric Nephrology, Germany (2004)
  • German Society of Pediatrics (1999)