Matthias Wolf, M.D.
Assistant Professor

Dr. Matthias Wolf is a Pediatric Nephrologist at UT Southwestern and Children’s Medical Center Dallas. He was born in Germany and attended Medical School at the Johannes Gutenberg University in Mainz, where he obtained his doctoral degree. Dr. Wolf finished his medical studies at the Ludwig-Maximilians University in Munich, Germany. He completed his five-year residency program at different academic centers in Germany, including the University Children’s Hospitals in Erlangen-Nuremberg, Berlin and Cologne. He interrupted his training for two years of postdoctoral fellowship training at the University of Michigan. Here, he studied the genetics of inherited kidney disorders, including different forms of cystic kidney disease and nephrotic syndrome. After his return to Germany, he passed the German Pediatric Board exam, and became one of the youngest assistant professors at the University Children’s Hospital in Cologne. In 2006, he returned to the United States and completed pediatric residency training at Children’s Medical Center in Dallas. He continued as a fellow in the Pediatric Nephrology program at UT Southwestern, which he successfully completed in 2012. During his fellowship training, Dr. Wolf joined Dr. Huang’s laboratory at UT Southwestern, where he learned patch-clamp recording, protein biochemistry, and mouse genetics. Dr. Wolf joined the faculty after graduating from fellowship. He has a strong interest in clinical aspects of renal channelopathies, magnesium and calcium homeostasis, inherited kidney diseases, cystic kidney disease, nephrotic syndrome, and nephrolithiasis. Dr. Wolf is a member of the editorial board of Pediatric Nephrology. In his laboratory, Dr. Wolf focuses on regulation of TRP (transient receptor potential) channels. He studies the regulation of TRP channels by urinary proteins and how this process contributes to common disorders such as kidney stones or type 2 diabetes mellitus. Dr. Wolf received the Carl W. Gottschalk Research Scholar grant from the American Society of Nephrology. His scientific contribution resulted in over 34 peer-reviewed publications and seven book chapters and reviews. He is currently supported by a NIH Career Development Award and funding by the Children’s Clinical Research Advisory Committee (CCRAC).

Internship

Ludwig-Maximilians-Universitat Munich (1999), Internal Medicine

Medical School

Johannes Gutenberg University Mainz (1999)

Residency

University Children's Hospital Erlangen-Nuremberg (2000), Pediatrics

Residency

Benjamin Franklin Childrens Hospital (2001), Pediatrics

Residency

University Children's Hospital, Freiburg Germany (2002), Pediatrics

Fellowship

University of Michigan Hospitals & Health Centers (2004), Research

Residency

University Children's Hospital, Charite, Berlin (2004), Neonatal-perinatal Medicine

Residency

University Children's Hospital Cologne Germany (2006), Pediatrics

Fellowship

University of Michigan Hospitals & Health Centers (2007), Research

Residency

UT Southwestern/Children's Medical Center (2009), Pediatrics

Fellowship

UT Southwestern/Children's Medical Center (2012), Pediatric Nephrology

Featured Publications

Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.

Braun DA, Rao J, Mollet G, Schapiro D, Daugeron MC, Tan W, Gribouval O, Boyer O, Revy P, Jobst-Schwan T, Schmidt JM, Lawson JA, Schanze D, Ashraf S, Ullmann JFP, Hoogstraten CA, Boddaert N, Collinet B, Martin G, Liger D, Lovric S, Furlano M, Guerrera IC, Sanchez-Ferras O, Hu JF, Boschat AC, Sanquer S, Menten B, Vergult S, De Rocker N, Airik M, Hermle T, Shril S, Widmeier E, Gee HY, Choi WI, Sadowski CE, Pabst WL, Warejko JK, Daga A, Basta T, Matejas V, Scharmann K, Kienast SD, Behnam B, Beeson B, Begtrup A, Bruce M, Ch'ng GS, Lin SP, Chang JH, Chen CH, Cho MT, Gaffney PM, Gipson PE, Hsu CH, Kari JA, Ke YY, Kiraly-Borri C, Lai WM, Lemyre E, Littlejohn RO, Masri A, Moghtaderi M, Nakamura K, Ozaltin F, Praet M, Prasad C, Prytula A, Roeder ER, Rump P, Schnur RE, Shiihara T, Sinha MD, Soliman NA, Soulami K, Sweetser DA, Tsai WH, Tsai JD, Topaloglu R, Vester U, Viskochil DH, Vatanavicharn N, Waxler JL, Wierenga KJ, Wolf MTF, Wong SN, Leidel SA, Truglio G, Dedon PC, Poduri A, Mane S, Lifton RP, Bouchard M, Kannu P, Chitayat D, Magen D, Callewaert B, van Tilbeurgh H, Zenker M, Antignac C, Hildebrandt F Nat. Genet. 2017 Aug

Omental Arteriopathy in Primary Atypical Hemolytic Uremic Syndrome.

Ellington N, Wolf MT, Kasten J, Rakheja D Int. J. Surg. Pathol. 2017 Mar 1066896917699703

Inherited and acquired disorders of magnesium homeostasis.

Wolf MT Curr. Opin. Pediatr. 2016 Nov

Mucin-1 Increases Renal TRPV5 Activity In Vitro, and Urinary Level Associates with Calcium Nephrolithiasis in Patients.

Nie M, Bal MS, Yang Z, Liu J, Rivera C, Wenzel A, Beck BB, Sakhaee K, Marciano DK, Wolf MT J. Am. Soc. Nephrol. 2016 Apr

Autosomal dominant tubulointerstitial kidney disease: diagnosis, classification, and management-A KDIGO consensus report.

Eckardt KU, Alper SL, Antignac C, Bleyer AJ, Chauveau D, Dahan K, Deltas C, Hosking A, Kmoch S, Rampoldi L, Wiesener M, Wolf MT, Devuyst O Kidney Int. 2015 Mar

Nephronophthisis and related syndromes.

Wolf MT Curr. Opin. Pediatr. 2015 Jan

Klotho upregulates renal calcium channel transient receptor potential vanilloid 5 (TRPV5) by intra- and extracellular N-glycosylation dependent mechanisms.

Wolf MT, An SW, Nie M, Bal MS, Huang CL J. Biol. Chem. 2014 Nov

Uromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosis.

Wolf MT, Wu XR, Huang CL Kidney Int. 2013 Mar

Autosomal dominant mutation in the signal peptide of renin in a kindred with anemia, hyperuricemia, and CKD.

Beck BB, Trachtman H, Gitman M, Miller I, Sayer JA, Pannes A, Baasner A, Hildebrandt F, Wolf MT Am. J. Kidney Dis. 2011 Nov 58 5 821-5

Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy.

Otto EA, Ramaswami G, Janssen S, Chaki M, Allen SJ, Zhou W, Airik R, Hurd TW, Ghosh AK, Wolf MT, Hoppe B, Neuhaus TJ, Bockenhauer D, Milford DV, Soliman NA, Antignac C, Saunier S, Johnson CA, Hildebrandt F J. Med. Genet. 2011 Feb 48 2 105-16

 Featured Books

Investigation of inherited renal disease. In Barratt J, Harris K, Topham P, eds. Oxford Desk Reference: Nephrology.

Hildebrandt F, Wolf MTF. (2008). Oxford University Press; 582-585.

Potassium Homeostasis in the Fetus and Neonate. In Polin RA, Abman SH, Rowitch D, Benitz WE, eds. Fetal and Neonatal Physiology. 5th ed.

Wolf MT, Benchimol C, Satlin LM, Quigley R. (2016). Philadelphia: Elsevier; 1011-1023.

Renal Tubular Acidosis in Children. In Avner ED, Harmon WE, Niaudet P, Yoshikawa N, Emma F, Goldstein SL, eds. Pediatric Nephrology. 7th ed.

Quigley R, Wolf MTF. (2016). Springer; 1273-1306.

• Junior Investigator Research Award, Children’s Clinical Research Advisory Committee
  Children's Medical Center Dallas (2016)
• Carl W. Gottschalk Research Scholar Grant
  American Society of Nephrology (2014)
• Junior Investigator Research Award, Children’s Clinical Research Advisory Committee
  Children's Medical Center Dallas (2013)
• Awarded Best Oral Presentation, Third Annual Senior Fellows' Research Day
  UT Southwestern Medical Center (2012)
• Pediatric Resident Research Award
  UT Southwestern Medical Center (2007-2009)

• International Pediatric Nephrology Association (2014)
• American Board of Pediatrics, Diplomate (2010)
• American Society for Nephrology (2009)
• American Medical Association (2008)
• American Academy of Pediatrics (2007)
• Society for Pediatric Nephrology, Germany (2004)
• German Society of Pediatrics (1999)