E. Sherwood Brown, M.D., Ph.D. MBA, is Professor of Psychiatry with Tenure, the Lou and Ellen McGinley Distinguished Chair in Psychiatric Research and Aradine S. Ard Chair in Brain Research, Vice Chair for Clinical Research, Chief of the Division of Clinical Neuroscience, and Director of the Psychoneuroendocrine Research Program at The University of Texas Southwestern Medical Center. He received B.A. and Ph.D. degrees in Chemistry from Texas Christian University. He received an M.D. degree from the University of Texas Medical School at Houston, and completed a psychiatry residency, on the research track, at UT Southwestern Medical Center followed by a research fellowship. He also completed an MBA,with Healthcare Organization Leadership Concentration, at the University of Texas at Dallas. He is board-certified in psychiatry and consultation-liaison psychiatry and is President-Elect of the Academy of Consultation-Liaison Psychiatry. 

He serves on several journal editorial boards including Biological Psychiatry:Cognitive Neuroscience and Neuroimaging  and Journal of Affective Disorders, and is Editor-in-Chief of the Journal of Dual Diagnosis. Dr. Brown’s research focuses on comorbidities of mood disorders including medical illness and substance abuse. He has had numerous grants from NIH and private foundations, including grants from NIAAA and NIDA examining the treatment of patients with bipolar disorder and substance dependence, a grant from NHLBI examining the treatment of depressed asthma patients, NIA exploring neurosteroid treatments for peri-menopausal depression and NIMH examining the effects of stress and corticosteroids on the human brain. He has published well over 200 research papers, books, chapters, reviews and editorials. 


Medical School
UT Health Science Center McGovern Medical School (1993)
UT Southwestern Medical Center (1994), Psychiatry
UT Southwestern Medical Center (1997), Psychiatry
UT Southwestern Medical Center (1998), Research

Research Interest

  • Depression in asthma patients
  • Effects of corticosteroids on the hippocampus
  • Treatment of bipolar depression
  • Treatment of patients with bipolar disorder and substance abuse


Featured Publications LegendFeatured Publications

Trust in Physicians and Regional Brain Volumes: A Population-Based Study.
Sadhu M, Jalalizadeh B, Fritz A, Nicholson TF, Garcia R, Lampley S, Rain M, Van Enkevort E, Brown ES, Prim Care Companion CNS Disord 2019 Oct 21 5
Subcortical gray matter volumes in asthma: associations with asthma duration, control, and anxiety.
Ritz T, Kroll JL, Aslan S, Janssens T, Khan DA, Pinkham AE, Brown ES, Brain Imaging Behav 2019 Sep
Effect of Selective Serotonin Reuptake Inhibitors on Healthcare Utilization in Patients with Post-Traumatic Stress Disorder and Alcohol Use Disorder.
Naglich AC, Bozeman S, Brown ES, Adinoff B, Alcohol Alcohol. 2019 Jun
A randomized trial of an NMDA receptor antagonist for reversing corticosteroid effects on the human hippocampus.
Brown ES, Kulikova A, Van Enkevort E, Nakamura A, Ivleva EI, Tustison NJ, Roberts J, Yassa MA, Choi C, Frol A, Khan DA, Vazquez M, Holmes T, Malone K, Neuropsychopharmacology 2019 Jun

Honors & Awards

  • Gerald L. Klerman Award
    Award for clinical research from National Alliance for Research in Schizophrenia and Depression (NARSAD) (2002)
  • Bristol-Myers Squibb Travel Fellowship
    American College of Neuropsychopharmacology (ACNP) Annual Meeting (1999)
  • Lilly Fellowship Travel Award
    Society of Biological Psychiatry Annual Convention (1998)
  • New Investigator Award
    Award from New Clinical Drug Evaluation Unit (NCDEU) (1997)

Professional Associations/Affiliations

  • Academy of Consultation-Liaison Psychiatry (2005)
  • American College of Neuropsychopharmacology (2004)
  • American Psychiatric Association (1993)
  • Research Society on Alcoholism (2007)
  • Society of Biological Psychiatry (2000)
  • Texas Medical Association (1993)