Bonnie Chase Prokesch, M.D., is an Associate Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of its Division of Infectious Diseases and Geographic Medicine. She specializes in the treatment of general infectious diseases, HIV and AIDS, pre-exposure prophylaxis (PrEP), recurrent urinary tract infections (UTIs), and postoperative infections.

Originally from Atlanta, Dr. Prokesch holds a bachelor's degree in social justice and political action from Connecticut College in New London, Connecticut, where she graduated summa cum laude. She earned her medical degree from Emory University in Atlanta, where she also completedinternal medicine residency training. She then received advanced training through infectious diseases fellowships at The Ohio State University Wexner Medical Center in Columbus, Ohio, and at UT Southwestern.

Certified by the American Board of Internal Medicine in infectious diseases, she joined the UT Southwestern faculty in 2016.

Dr. Prokesch is a Fellow of the American College of Physicians and Director of Antimicrobial Stewardship at Parkland Health & Hospital System, where she also serves on several committees, including the Pharmacy and Therapeutics Committee.Additionally, she is a member of the American Society for Microbiology, the American Association for the Advancement of Science, the Infectious Diseases Society of America, and several other professional organizations.

Her research interests include antimicrobial resistance, antibiotic stewardship, recurrent UTI treatment, and immunocompromised hosts. She has delivered scores of invited lectures and published numerous academic articles.

In 2014, she earned the Fellowship Antimicrobial Stewardship Award from UT Southwestern.


Medical School
Emory University School of Medicine (2009)
Emory University School of Medicine (2012), Internal Medicine
Ohio State University Hospital (2013), Infectious Diseases
UT Southwestern Medical Center (2014), Infectious Diseases

Research Interest

  • Antibiotic Stewardship
  • Antimicrobial Resistance
  • Hemophagocytic lymphohistiocytosis
  • HIV
  • Immunocompromised Hosts
  • Socioeconomic Impact of Infectious Diseases


Featured Publications LegendFeatured Publications

Minimal Cerebrospinal Concentration of Miltefosine Despite Therapeutic Plasma Levels During the Treatment of Amebic Encephalitis.
Monogue ML, Watson D, Alexander JS, Cavuoti D, Doyle LM, Wang MZ, Prokesch BC, Antimicrob. Agents Chemother. 2019 Nov
What lies beneath: severe infection presenting as leucocytoclastic vasculitis.
Alexander JS, Prokesch BC, Lancet Infect Dis 2019 Apr 19 4 448
What's in a name? The heterogeneous clinical spectrum and prognostic factors in a cohort of adults with hemophagocytic lymphohistiocytosis.
Prokesch BC, Nagalla S, Ezzati F, Tujios SR, Dominguez A, Chen W, Kershaw C, Patel P, de la Flor C, Foster J, Martin AA, de la Morena MT, Wysocki CA Transfus. Apher. Sci. 2018 Oct
Letermovir successfully used for secondary prophylaxis in a heart transplant recipient with ganciclovir-resistant cytomegalovirus syndrome (UL97 mutation).
Chong PP, Teiber D, Prokesch BC, Arasaratnam RJ, Peltz M, Drazner MH, Garg S Transpl Infect Dis 2018 Jul e12965
Successful Treatment of Persistent Burkholderia cepacia Complex Bacteremia with Ceftazidime-Avibactam.
Tamma PD, Fan Y, Bergman Y, Sick-Samuels AC, Hsu AJ, Timp W, Simner PJ, Prokesch BC, Greenberg DE Antimicrob. Agents Chemother. 2018 Apr 62 4
in a Patient With Sickle Cell Disease.
Hill E, Workman AD, Lee F, Hollaway R, Cavuoti D, Prokesch BC Open Forum Infect Dis 2018 Feb 5 2 ofx278
A 60-year-old man with necrotic skin lesions after heart transplantation.
Prokesch BC, Cavuoti D, Le JB, Greenberg DE Am. J. Transplant. 2014 Nov 14 11 2664-6
EBV-driven HIV-associated diffuse large B-cell lymphoma causing profound lactic acidosis.
Prokesch BC, Shiloh MU Blood 2014 Aug 124 6 842
Nail gun attempted suicide and traumatic ventricular perforations.
Prokesch BC, Mangino JE QJM 2014 Jul 107 7 589

Honors & Awards

  • Alpha Omega Alpha
    Medical Honor Society (2014)
  • Fellowship Antimicrobial Stewardship Award
    UT Southwestern (2014)
  • Fellow's Excellence in Teaching Award
    Ohio State University (2013)
  • Phi Beta Kappa
    National Honor Society (2004)
  • Pi Sigma Alpha
    National Political Science Honor Society (2004)

Professional Associations/Affiliations

  • American Association for the Advancement of Science (2015)
  • American College of Physicians (2009)
  • Infectious Diseases Society of America (2013)