Masaki Mizuno, Ph.D.

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Dr. Mizuno earned his doctroral degree in 2005 from Waseda University in Tokyo, Japan. He completed a postdoctoral fellowship at UT Southwestern in 2009 and then joined the faculty in 2011. He is currently an active member of the American Physiological Society, American College of Sports Medicine and American Heart Association.

Dr. Mizuno's laboratory has been studying autonomic control of the cardiovascular system. Current research focuses on examining the mechanisms underlying alterations in circulatory control in type1 or type2 diabetes. More specifically, the lab is actively investigating the central and peripheral mechanisms underpinning the abnormal elevations in sympathetic nerve activity that accompany the pathogenesis of these diseases.

Undergraduate

Waseda University (2000)

Graduate School

Waseda University (2002)

Graduate School

Waseda University (2005)

• Autonomic Dysfunction in Diabetes
• Neural Control of Cardiovascular Systems

Featured Publications

Blockade of endogenous insulin receptor signaling in the nucleus tractus solitarius potentiates exercise pressor reflex function in healthy male rats.

Estrada JA, Hotta N, Kim HK, Ishizawa R, Fukazawa A, Iwamoto GA, Smith SA, Vongpatanasin W, Mizuno M, FASEB J 2023 Sep 37 9 e23141

High-glycemic index meal acutely potentiates blood pressure response to static handgrip exercise in healthy humans.

Kashima H, Endo MY, Kanda M, Miura A, Fukuba Y, Mizuno M, J Appl Physiol (1985) 2023 Jul

Neural discharge of muscle afferents and pressor response to mechanical stimulation are associated with muscle deformation velocity in rats.

Ishizawa R, Estrada J, Kim HK, Hotta N, Fukazawa A, Iwamoto GA, Smith SA, Vongpatanasin W, Mizuno M, Am J Physiol Regul Integr Comp Physiol 2023 Apr

Antagonism of TRPV4 channels partially reduces mechanotransduction in rat skeletal muscle afferents.

Fukazawa A, Hori A, Norio H, Katanosaka K, Estrada JA, Ishizawa R, Kim HK, Iwamoto GA, Smith SA, Vongpatanasin W, Mizuno M, J Physiol 2023 Mar

Insulin potentiates the response to capsaicin in dorsal root ganglion neurons in vitro and muscle afferents ex vivo in normal healthy rodents.

Hori A, Norio H, Fukazawa A, Estrada JA, Katanosaka K, Mizumura K, Sato J, Ishizawa R, Kim HK, Iwamoto GA, Vongpatanasin W, Mitchell JH, Smith SA, Mizuno M, J Physiol 2021 Dec

The Impact of Insulin Resistance on Cardiovascular Control during Exercise in Diabetes.

Mizuno M, Hotta N, Ishizawa R, Kim HK, Iwamoto G, Vongpatanasin W, Mitchell JH, Smith SA, Exerc Sport Sci Rev 2021 May

TRPV1 (Transient Receptor Potential Vanilloid 1) Sensitization of Skeletal Muscle Afferents in Type 2 Diabetic Rats With Hyperglycemia.

Ishizawa R, Kim HK, Hotta N, Iwamoto GA, Mitchell JH, Smith SA, Vongpatanasin W, Mizuno M, Hypertension 2021 Mar HYPERTENSIONAHA12015672

Insulin resistance is associated with an exaggerated blood pressure response to ischemic rhythmic handgrip exercise in non-diabetic older adults.

Hotta N, Hori A, Okamura Y, Baba R, Watanabe H, Sugawara J, Vongpatanasin W, Wang J, Kim HK, Ishizawa R, Iwamoto GA, Mitchell JH, Smith SA, Mizuno M, J. Appl. Physiol. 2020 Jun

Skeletal Muscle Reflex-Induced Sympathetic Dysregulation and Sensitization of Muscle Afferents in Type 1 Diabetic Rats.

Ishizawa R, Kim HK, Hotta N, Iwamoto GA, Vongpatanasin W, Mitchell JH, Smith SA, Mizuno M, Hypertension 2020 Feb HYPERTENSIONAHA11914118

Insulin potentiates the response to mechanical stimuli in small dorsal root ganglion neurons and thin fibre muscle afferents in vitro.

Hotta N, Katanosaka K, Mizumura K, Iwamoto GA, Ishizawa R, Kim HK, Vongpatanasin W, Mitchell JH, Smith SA, Mizuno M, J. Physiol. (Lond.) 2019 Aug

• Fellow ACSM
  American College of Sports Medicine (2023)
• Established Investigator Award
  Southwestern School of Health Professions (2022)
• Pilot Synergy Grants for Collaborative Research
  UTSW Circle of Friends (2022-2023)
• Basic Research Grant (R01)
  National Institutes of Health, NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (2020-2024)
• Interdisciplinary Research Grant Program(1), Co-PI
  Southwestern School of Health Professions (2019-2020)
• Interdisciplinary Research Grant Program(2), Co-PI
  Southwestern School of Health Professions (2019-2020)
• Outstanding Junior Faculty Award
  Southwestern School of Health Professions (2019)
• Interdisciplinary Research Grant Program, PI
  Southwestern School of Health Professions (2018-2019)
• Interdisciplinary Research Grant Program, Co-PI
  Southwestern School of Health Professions (2017-2018)
• New Investigator Award
  Southwestern School of Health Professions (2016)
• Pilot and Feasibility Program
  O-Brien Kidney Research Core Center (2015-2016)
• Excellent Young Researchers Overseas Visit Program
  Japan Society for the Promotion of Science (2010)
• Fellowship for Research Abroad
  The Naito Foundation (2009)
• Fellowships for Research Abroad
  The Nakatomi Foundation (2009)
• Research Fellowships for Young Scientists
  Japan Society for the Promotion of Science (2009)
• Incentive Award
  Neurocardiology Workshop (2007)
• Young Investigator Award
  Japan Society of Physical Fitness and Sports Medicine (2004)

• American College of Sports Medicine (2009)
• American Heart Association (2015)
• American Physiological Society (2007)