Masaki Mizuno, Ph.D. Associate Professor School School of Health Professions Department Applied Clinical Research | Internal Medicine Biography Download Curriculum Vitae Dr. Mizuno earned his doctoral degree in 2005 from Waseda University in Tokyo, Japan. He completed a postdoctoral fellowship at UT Southwestern in 2011 and then joined the faculty. He is currently an active member of the American Physiological Society, the American Heart Association, and Fellow of the American College of Sports Medicine. Dr. Mizuno's laboratory has been studying autonomic control of the cardiovascular system. Current research focuses on examining the mechanisms underlying alterations in circulatory control in type1 or type2 diabetes. More specifically, the lab is actively investigating the central and peripheral mechanisms underpinning the abnormal elevations in sympathetic nerve activity that accompany the pathogenesis of these diseases. Education Undergraduate Waseda University (2000) Graduate School Waseda University (2002) Graduate School Waseda University (2005) Research Interest Autonomic Dysfunction in Diabetes Neural Control of Cardiovascular Systems Publications Featured Publications Intracerebroventricular insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 diabetes mellitus. Estrada JA, Ishizawa R, Kim HK, Fukazawa A, Hori A, Hotta N, Iwamoto GA, Smith SA, Vongpatanasin W, Mizuno M, J Physiol 2024 Aug Blockade of endogenous insulin receptor signaling in the nucleus tractus solitarius potentiates exercise pressor reflex function in healthy male rats. Estrada JA, Hotta N, Kim HK, Ishizawa R, Fukazawa A, Iwamoto GA, Smith SA, Vongpatanasin W, Mizuno M, FASEB J 2023 Sep 37 9 e23141 High-glycemic index meal acutely potentiates blood pressure response to static handgrip exercise in healthy humans. Kashima H, Endo MY, Kanda M, Miura A, Fukuba Y, Mizuno M, J Appl Physiol (1985) 2023 Jul Neural discharge of muscle afferents and pressor response to mechanical stimulation are associated with muscle deformation velocity in rats. Ishizawa R, Estrada J, Kim HK, Hotta N, Fukazawa A, Iwamoto GA, Smith SA, Vongpatanasin W, Mizuno M, Am J Physiol Regul Integr Comp Physiol 2023 Apr Antagonism of TRPV4 channels partially reduces mechanotransduction in rat skeletal muscle afferents. Fukazawa A, Hori A, Norio H, Katanosaka K, Estrada JA, Ishizawa R, Kim HK, Iwamoto GA, Smith SA, Vongpatanasin W, Mizuno M, J Physiol 2023 Mar Insulin potentiates the response to capsaicin in dorsal root ganglion neurons in vitro and muscle afferents ex vivo in normal healthy rodents. Hori A, Norio H, Fukazawa A, Estrada JA, Katanosaka K, Mizumura K, Sato J, Ishizawa R, Kim HK, Iwamoto GA, Vongpatanasin W, Mitchell JH, Smith SA, Mizuno M, J Physiol 2021 Dec The Impact of Insulin Resistance on Cardiovascular Control during Exercise in Diabetes. Mizuno M, Hotta N, Ishizawa R, Kim HK, Iwamoto G, Vongpatanasin W, Mitchell JH, Smith SA, Exerc Sport Sci Rev 2021 May TRPV1 (Transient Receptor Potential Vanilloid 1) Sensitization of Skeletal Muscle Afferents in Type 2 Diabetic Rats With Hyperglycemia. Ishizawa R, Kim HK, Hotta N, Iwamoto GA, Mitchell JH, Smith SA, Vongpatanasin W, Mizuno M, Hypertension 2021 Mar HYPERTENSIONAHA12015672 Insulin resistance is associated with an exaggerated blood pressure response to ischemic rhythmic handgrip exercise in non-diabetic older adults. Hotta N, Hori A, Okamura Y, Baba R, Watanabe H, Sugawara J, Vongpatanasin W, Wang J, Kim HK, Ishizawa R, Iwamoto GA, Mitchell JH, Smith SA, Mizuno M, J. Appl. Physiol. 2020 Jun Skeletal Muscle Reflex-Induced Sympathetic Dysregulation and Sensitization of Muscle Afferents in Type 1 Diabetic Rats. Ishizawa R, Kim HK, Hotta N, Iwamoto GA, Vongpatanasin W, Mitchell JH, Smith SA, Mizuno M, Hypertension 2020 Feb HYPERTENSIONAHA11914118 Results 1-10 of 61 1 2 3 4 5 Next Last Honors & Awards Fellow ACSMAmerican College of Sports Medicine (2023) Established Investigator AwardSouthwestern School of Health Professions (2022) Pilot Synergy Grants for Collaborative ResearchUTSW Circle of Friends (2022-2023) Basic Research Grant (R01)National Institutes of Health, NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (2020-2024) Interdisciplinary Research Grant Program(1), Co-PISouthwestern School of Health Professions (2019-2020) Interdisciplinary Research Grant Program(2), Co-PISouthwestern School of Health Professions (2019-2020) Outstanding Junior Faculty AwardSouthwestern School of Health Professions (2019) Interdisciplinary Research Grant Program, PISouthwestern School of Health Professions (2018-2019) Interdisciplinary Research Grant Program, Co-PISouthwestern School of Health Professions (2017-2018) New Investigator AwardSouthwestern School of Health Professions (2016) Pilot and Feasibility ProgramO-Brien Kidney Research Core Center (2015-2016) Excellent Young Researchers Overseas Visit ProgramJapan Society for the Promotion of Science (2010) Fellowship for Research AbroadThe Naito Foundation (2009) Fellowships for Research AbroadThe Nakatomi Foundation (2009) Research Fellowships for Young ScientistsJapan Society for the Promotion of Science (2009) Incentive AwardNeurocardiology Workshop (2007) Young Investigator AwardJapan Society of Physical Fitness and Sports Medicine (2004) Professional Associations/Affiliations American College of Sports Medicine (2009) American Heart Association (2015) American Physiological Society (2007)
