Anju Sreelatha, Ph.D. Titles and Appointments Assistant Professor Endowed Title W. W. Caruth, Jr. Scholar in Biomedical Research School Medical School Department Physiology | Charles and Jane Pak Center for Mineral Metabolism and Clinical Research Graduate Programs Biological Chemistry, Cell and Molecular Biology Biography Dr. Anju Sreelatha received her B.S. in Biochemistry from the University of Texas at Dallas in 2009. Following a research fellowship with the UT Dallas Green Fellows Program, Dr. Sreelatha earned her Ph.D. from UT Southwestern in 2014 under the supervision of Kim Orth, Ph.D. During her graduate work, she identified the biochemical activity and molecular mechanism of a bacterial effector protein, VopQ. These studies provided a better understanding of bacterial pathogenesis and also offered new insight into the host cell mechanisms of autophagy and vesicle fusion. As a postdoctoral fellow with Vincent Tagliabracci, Ph.D. she discovered a new catalytic activity for the protein kinase fold and the selenoprotein family. Her postdoctoral work on Selenoprotein O revealed a new paradigm in cellular antioxidant pathways. In 2019, Anju joined the Department of Physiology as an Assistant Professor. The Sreelatha lab is focused on studying the role of SelO in the mitochondria using mammalian systems. The lab utilizes a multidisciplinary approach with structural biology, biochemistry, molecular biology, and cell biology to unravel the molecular mechanisms of selenoproteins in health and disease. Education Undergraduate University of Texas at Dallas (2009), Biochemistry Graduate School UT Southwestern Medical Center (2014), Biochemistry Research Interest Mitochondrial Redox Oxidative Stress Response Selenoproteins Publications Featured Publications Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II Activity. Nascentes Melo LM, Sabatier M, Ramesh V, Szylo KJ, Fraser CS, Pon A, Mitchell EC, Servage KA, Allies G, Westedt IV, Cansiz F, Krystkiewicz J, Kutritz A, Schadendorf D, Morrison SJ, Ubellacker JM, Sreelatha A, Tasdogan A, Cancer Res 2024 Dec Utilizing Thermal Shift Assay to Probe Substrate Binding to Selenoprotein O. Gonzalez A, Sreelatha A, J Vis Exp 2024 Aug 210 Emerging functions of pseudoenzymes. Goldberg T, Sreelatha A, Biochem J 2023 May 480 10 715-728 Redefining pseudokinases: A look at the untapped enzymatic potential of pseudokinases. Pon A, Osinski A, Sreelatha A, IUBMB Life 2023 Apr 75 4 370-376 Identification of selenoprotein O substrates using a biotinylated ATP analog. Mukherjee M, Sreelatha A, Methods Enzymol 2022 662 275-296 A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity. Lopez VA, Park BC, Nowak D, Sreelatha A, Zembek P, Fernandez J, Servage KA, Gradowski M, Hennig J, Tomchick DR, Pawlowski K, Krzymowska M, Tagliabracci VS, Cell 2019 Sep 179 1 205-218.e21 Protein AMPylation by an Evolutionarily Conserved Pseudokinase. Sreelatha A, Yee SS, Lopez VA, Park BC, Kinch LN, Pilch S, Servage KA, Zhang J, Jiou J, Karasiewicz-Urbanska M, Lobocka M, Grishin NV, Orth K, Kucharczyk R, Pawlowski K, Tomchick DR, Tagliabracci VS, Cell 2018 10 175 3 809-821.e19 Phosphorylation of spore coat proteins by a family of atypical protein kinases. Nguyen KB, Sreelatha A, Durrant ES, Lopez-Garrido J, Muszewska A, Dudkiewicz M, Grynberg M, Yee S, Pogliano K, Tomchick DR, Pawlowski K, Dixon JE, Tagliabracci VS, Proc. Natl. Acad. Sci. U.S.A. 2016 06 113 25 E3482-91 The secretory pathway kinases. Sreelatha A, Kinch LN, Tagliabracci VS, Biochim. Biophys. Acta 2015 Oct 1854 10 Pt B 1687-93 Vibrio effector protein VopQ inhibits fusion of V-ATPase-containing membranes. Sreelatha A, Bennett TL, Carpinone EM, O'Brien KM, Jordan KD, Burdette DL, Orth K, Starai VJ, Proc. Natl. Acad. Sci. U.S.A. 2015 Jan 112 1 100-5 Results 1-10 of 15 1 2 Next Last
