Education

Undergraduate
Fudan University (1992), Genetics
Graduate School
Fudan University (1995), Genetics
Graduate School
University of Texas at Austin (2001), Molecular Biology

Research Interest

  • Epigenetic regulation of gene expression in neural development and autistic disorders
  • Epigenetic regulation of Sonic hedgehog signaling in development and cancers
  • Transcription regulation of neuronal synapse development and plasticity

Publications

Featured Publications LegendFeatured Publications

Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis.
Stankunas K, Hang CT, Tsun ZY, Chen H, Lee NV, Wu JI, Shang C, Bayle JH, Shou W, Iruela-Arispe ML, Chang CP Dev. Cell 2008 Feb 14 2 298-311
Targeted disruption of Mib2 causes exencephaly with a variable penetrance.
Wu JI, Rajendra R, Barsi JC, Durfee L, Benito E, Gao G, Kuruvilla M, Hrdlickov√° R, Liss AS, Artzt K Genesis 2007 Nov 45 11 722-7
Tint maps to mouse chromosome 6 and may interact with a notochordal enhancer of Brachyury.
Wu JI, Centilli MA, Vasquez G, Young S, Scolnick J, Durfee LA, Spearow JL, Schwantz SD, Rennebeck G, Artzt K Genetics 2007 Oct 177 2 1151-61
Cell signaling. Nuclear actin as choreographer of cell morphology and transcription.
Wu JI, Crabtree GR, Crabtee GR Science 2007 Jun 316 5832 1710-1
An essential switch in subunit composition of a chromatin remodeling complex during neural development
Lessard, J.*, Wu, J. I.*, Ranish, J. A., Wan, M., Winslow, M. M., Staahl, B. T., Wu, H., Aebersold, R., Graef, I. A., and Crabtree, G. R. Neuron 2007 55 201-215
Regulation of dendritic development by neuron-specific chromatin remodeling complexes
Wu, J. I., Lessard, J., Olave, I. A., Qiu, Z. Ghosh, A., Graef, I. A., and Crabtree, G. R. Neuron 2007 56 94-108
Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling.
Barsi JC, Rajendra R, Wu JI, Artzt K Mech. Dev. 2005 Oct 122 10 1106-17
Function of quaking in myelination: regulation of alternative splicing.
Wu JI, Reed RB, Grabowski PJ, Artzt K Proc. Natl. Acad. Sci. U.S.A. 2002 Apr 99 7 4233-8
A role for KH domain proteins (Sam68-like mammalian proteins and quaking proteins) in the post-transcriptional regulation of HIV replication.
Reddy TR, Suhasini M, Xu W, Yeh LY, Yang JP, Wu J, Artzt K, Wong-Staal F J. Biol. Chem. 2002 Feb 277 8 5778-84
The quaking I-5 protein (QKI-5) has a novel nuclear localization signal and shuttles between the nucleus and the cytoplasm.
Wu J, Zhou L, Tonissen K, Tee R, Artzt K J. Biol. Chem. 1999 Oct 274 41 29202-10

Honors & Awards

  • American Cancer Society Research Scholar
    (2013)
  • Basil O’Connor starter scholar
    (2010)
  • Whitehall Foundation award
    (2010)
  • Endowed Scholar in Biomedical Research
    UT Southwestern Medical Center (2008)