Education

Undergraduate
Fudan University (1992), Genetics
Graduate School
Fudan University (1995), Genetics
Graduate School
University of Texas at Austin (2001), Molecular Biology

Research Interest

  • Epigenetic regulation of gene expression in neural development and autistic disorders
  • Epigenetic regulation of Sonic hedgehog signaling in development and cancers
  • Transcription regulation of neuronal synapse development and plasticity

Publications

Featured Publications LegendFeatured Publications

Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling.
Han Y, Wang B, Cho YS, Zhu J, Wu J, Chen Y, Jiang J, Dev. Cell 2019 Jun
Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-ß2 nuclear import system.
Han Y, Xiong Y, Shi X, Wu J, Zhao Y, Jiang J PLoS Biol. 2017 Aug 15 8 e2002063
The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network.
Ninkovic J, Steiner-Mezzadri A, Jawerka M, Akinci U, Masserdotti G, Petricca S, Fischer J, von Holst A, Beckers J, Lie CD, Petrik D, Miller E, Tang J, Wu J, Lefebvre V, Demmers J, Eisch A, Metzger D, Crabtree G, Irmler M, Poot R, Götz M Cell Stem Cell 2013 Oct 13 4 403-18
The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory.
Vogel-Ciernia A, Matheos DP, Barrett RM, Kramár EA, Azzawi S, Chen Y, Magnan CN, Zeller M, Sylvain A, Haettig J, Jia Y, Tran A, Dang R, Post RJ, Chabrier M, Babayan AH, Wu JI, Crabtree GR, Baldi P, Baram TZ, Lynch G, Wood MA Nat. Neurosci. 2013 Mar
NF-?B Forms a Complex with the Chromatin Remodeler BRG1 to Regulate Schwann Cell Differentiation.
Limpert AS, Bai S, Narayan M, Wu J, Yoon SO, Carter BD, Lu QR J. Neurosci. 2013 Feb 33 6 2388-2397
Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation.
Yu Y, Chen Y, Kim B, Wang H, Zhao C, He X, Liu L, Liu W, Wu LM, Mao M, Chan JR, Wu J, Lu QR Cell 2013 Jan 152 1-2 248-61
STAR trek: An introduction to STAR family proteins and review of quaking (QKI).
Artzt K, Wu JI Adv. Exp. Med. Biol. 2010 693 1-24
An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency.
Ho L, Ronan JL, Wu J, Staahl BT, Chen L, Kuo A, Lessard J, Nesvizhskii AI, Ranish J, Crabtree GR Proc. Natl. Acad. Sci. U.S.A. 2009 Mar 106 13 5181-6
Understanding the words of chromatin regulation.
Wu JI, Lessard J, Crabtree GR Cell 2009 Jan 136 2 200-6

Honors & Awards

  • American Cancer Society Research Scholar
    (2013)
  • Basil O’Connor starter scholar
    (2010)
  • Whitehall Foundation award
    (2010)
  • Endowed Scholar in Biomedical Research
    UT Southwestern Medical Center (2008)