Jiang Wu, Ph.D.

Undergraduate

Fudan University (1992), Genetics

Graduate School

Fudan University (1995), Genetics

Graduate School

University of Texas at Austin (2001), Molecular Biology

• Epigenetic regulation of gene expression in neural development and autistic disorders
• Epigenetic regulation of Sonic hedgehog signaling in development and cancers
• Transcription regulation of neuronal synapse development and plasticity

Featured Publications

PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma.

Yi J, Kim B, Shi X, Zhan X, Lu QR, Xuan Z, Wu J, Cancer Res 2022 Jun

Targeting H3K27me3 demethylase to inhibit Shh signaling and cholesterol metabolism in medulloblastoma growth.

Deng H, Guo X, Feng N, Luo Y, Liu B, Liu S, Wu JI, Shi X, Front Oncol 2022 12 1057147

Neuronal activity-induced BRG1 phosphorylation regulates enhancer activation.

Kim B, Luo Y, Zhan X, Zhang Z, Shi X, Yi J, Xuan Z, Wu J, Cell Rep 2021 Jul 36 2 109357

Histone demethylase UTX/KDM6A enhances tumor immune cell recruitment, promotes differentiation and suppresses medulloblastoma.

Yi J, Shi X, Xuan Z, Wu J, Cancer Lett 2020 Nov

A proteomic approach identifies SAFB-like transcription modulator (SLTM) as a bidirectional regulator of GLI family zinc finger transcription factors.

Zhang Z, Zhan X, Kim B, Wu J J. Biol. Chem. 2019 Feb

Epigenetic regulation in medulloblastoma.

Yi J, Wu J Mol. Cell. Neurosci. 2017 Dec

SMARCA4/Brg1 coordinates genetic and epigenetic networks underlying Shh-type medulloblastoma development.

Shi X, Wang Q, Gu J, Xuan Z, Wu JI Oncogene 2016 Apr

Autism-Associated Chromatin Regulator Brg1/SmarcA4 is Required for Synapse Development and MEF2-mediated Synapse Remodeling.

Zhang Z, Cao M, Chang CW, Wang C, Shi X, Zhan X, Birnbaum SG, Bezprozvanny I, Huber K, Wu JI Mol. Cell. Biol. 2015 Oct

Chromatin Remodeling Factor Brg1 Supports the Early Maintenance and Late Responsiveness of Nestin-Lineage Adult Neural Stem and Progenitor Cells.

Petrik D, Latchney SE, Masiulis I, Yun S, Zhang Z, Wu JI, Eisch AJ Stem Cells 2015 Sep

Generation of BAF53b-Cre transgenic mice with pan-neuronal Cre activities.

Zhan X, Cao M, Yoo AS, Zhang Z, Chen L, Crabtree GR, Wu JI Genesis 2015 Jun

• American Cancer Society Research Scholar
  (2013)
• Basil O’Connor starter scholar
  (2010)
• Whitehall Foundation award
  (2010)
• Endowed Scholar in Biomedical Research
  UT Southwestern Medical Center (2008)