
Jiang Wu, Ph.D.
Associate Professor
Endowed Title Virginia Murchison Linthicum Scholar in Medical Research
School Medical School
Department Physiology
Graduate Programs Genetics, Development and Disease, Neuroscience
Education
- Undergraduate
- Fudan University (1992), Genetics
- Graduate School
- Fudan University (1995), Genetics
- Graduate School
- University of Texas at Austin (2001), Molecular Biology
Research Interest
- Epigenetic regulation of gene expression in neural development and autistic disorders
- Epigenetic regulation of Sonic hedgehog signaling in development and cancers
- Transcription regulation of neuronal synapse development and plasticity
Publications
Featured Publications
- PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma.
- Yi J, Kim B, Shi X, Zhan X, Lu QR, Xuan Z, Wu J, Cancer Res 2022 Jun
- Targeting H3K27me3 demethylase to inhibit Shh signaling and cholesterol metabolism in medulloblastoma growth.
- Deng H, Guo X, Feng N, Luo Y, Liu B, Liu S, Wu JI, Shi X, Front Oncol 2022 12 1057147
- Neuronal activity-induced BRG1 phosphorylation regulates enhancer activation.
- Kim B, Luo Y, Zhan X, Zhang Z, Shi X, Yi J, Xuan Z, Wu J, Cell Rep 2021 Jul 36 2 109357
- Histone demethylase UTX/KDM6A enhances tumor immune cell recruitment, promotes differentiation and suppresses medulloblastoma.
- Yi J, Shi X, Xuan Z, Wu J, Cancer Lett 2020 Nov
- A proteomic approach identifies SAFB-like transcription modulator (SLTM) as a bidirectional regulator of GLI family zinc finger transcription factors.
- Zhang Z, Zhan X, Kim B, Wu J J. Biol. Chem. 2019 Feb
- Epigenetic regulation in medulloblastoma.
- Yi J, Wu J Mol. Cell. Neurosci. 2017 Dec
- SMARCA4/Brg1 coordinates genetic and epigenetic networks underlying Shh-type medulloblastoma development.
- Shi X, Wang Q, Gu J, Xuan Z, Wu JI Oncogene 2016 Apr
- Autism-Associated Chromatin Regulator Brg1/SmarcA4 is Required for Synapse Development and MEF2-mediated Synapse Remodeling.
- Zhang Z, Cao M, Chang CW, Wang C, Shi X, Zhan X, Birnbaum SG, Bezprozvanny I, Huber K, Wu JI Mol. Cell. Biol. 2015 Oct
- Chromatin Remodeling Factor Brg1 Supports the Early Maintenance and Late Responsiveness of Nestin-Lineage Adult Neural Stem and Progenitor Cells.
- Petrik D, Latchney SE, Masiulis I, Yun S, Zhang Z, Wu JI, Eisch AJ Stem Cells 2015 Sep
- Generation of BAF53b-Cre transgenic mice with pan-neuronal Cre activities.
- Zhan X, Cao M, Yoo AS, Zhang Z, Chen L, Crabtree GR, Wu JI Genesis 2015 Jun
Honors & Awards
- American Cancer Society Research Scholar
(2013) - Basil O’Connor starter scholar
(2010) - Whitehall Foundation award
(2010) - Endowed Scholar in Biomedical Research
UT Southwestern Medical Center (2008)