Biography

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Joseph S. Takahashi is Chair of the Department of Neuroscience and an Investigator of the Howard Hughes Medical Institute at UT Southwestern Medical Center. He currently holds the Loyd B. Sands Distinguished Chair in Neuroscience. Before moving to UT Southwestern, Dr. Takahashi was the Walter and Mary Elizabeth Glass Professor in the Life Sciences at Northwestern University. During his 26-year tenure at Northwestern, he held appointments as professor in the Department of Neurobiology and Physiology on the Evanston campus and professor in the Department of Neurology at Northwestern University Medical School. In addition, he was also the director of the Center for Functional Genomics.

Dr. Takahashi received a BA in biology from Swarthmore College in 1974 and a PhD in neuroscience from the University of Oregon, Eugene, in 1981. For postdoctoral training, he was a pharmacology research associate at the National Institute of Mental Health from 1981-1983.

Dr. Takahashi has pioneered the use of forward genetics and positional cloning in the mouse as a tool for discovery of genes underlying neurobiology and behavior, and his discovery of the mouse and human clock genes led to a description of a conserved circadian clock mechanism in animals.

He is the author of more than 260 scientific publications and the recipient of many awards including the Honma Prize in Biological Rhythms Research, NSF Presidential Young Investigator Award, Searle Scholars Award, Bristol-Myers Squibb Unrestricted Grant in Neuroscience, and the C. U. Ariens Kappers Medal. He received the W. Alden Spencer Award in Neuroscience from Columbia University in 2001, was elected a Fellow of the American Academy of Arts and Sciences in 2000, a Member of the National Academy of Sciences in 2003 and a Member of the National Academy of Medicine in 2014.

Dr. Takahashi has served on a number of advisory committees for the National Institutes of Health, as well as scientific advisory boards for Eli Lilly and Company, Bristol-Myers Squibb Neuroscience Committee, the Genomics Research Institute for the Novartis Foundation, the Klingenstein Fund, the Searle Scholars Foundation, the McKnight Foundation, the Allen Institute for Brain Science, the Max Planck Institute for Biophysical Chemistry, and the Restless Legs Syndrome Foundation. He was also a co-founder of Hypnion, Inc., a biotech discovery company in Worcester, Mass., that investigated sleep/wake neurobiology and pharmaceuticals (now owned by Eli Lilly and Co.). He is a co-founder of ReSet Therapeutics, Inc., a biotech company that works on the role of clocks in metabolism.

He is on the Editorial Boards for PNAS, eLife, J Biol Rhythms, Neurobiology of Sleep and Circadian Rhythms, Genes, Brain and Behavior, and Section Head, Animal Genetics, Biology Reports Ltd., Faculty of 1000.  

Education

Undergraduate
Swarthmore College (1974), Biology
Graduate School
University of Oregon (1981), Biology

Research Interest

  • Circadian Biology
  • Genetic Dissection of Behavior
  • Molecular Neuroscience
  • Mouse Genetics and Genomics
  • Oscillator dynamics

Publications

Featured Publications LegendFeatured Publications

PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues.
Yoo SH, Yamazaki S, Lowrey PL, Shimomura K, Ko CH, Buhr ED, Siepka SM, Hong HK, Oh WJ, Yoo OJ, Menaker M, Takahashi JS Proc. Natl. Acad. Sci. U.S.A. 2004 Apr 101 15 5339-46
Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau.
Lowrey PL, Shimomura K, Antoch MP, Yamazaki S, Zemenides PD, Ralph MR, Menaker M, Takahashi JS Science 2000 Apr 288 5465 483-92
Functional identification of the mouse circadian Clock gene by transgenic BAC rescue.
Antoch, M.P., E.-J. Song, A.-M. Chang, M.H. Vitaterna, Y. Zhao, L.D. Wilsbacher, A.M. Sangoram, D.P. King, L.H. Pinto and J.S. Takahashi. Cell 1997 89:655-667. 12
Positional cloning of the mouse circadian Clock gene.
King, D.P., Y. Zhao, A.M. Sangoram, L.D. Wilsbacher, M. Tanaka, M.P. Antoch, T.D.L. Steeves, M.H. Vitaterna, J.M. Kornhauser, P.L. Lowrey, F.W. Turek and J.S. Takahashi. Cell 1997 89:641-653. 12
Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior.
Vitaterna, M.H., D.P. King, A.-M. Chang, J.M. Kornhauser, P.L. Lowrey, J.D. McDonald, W.F. Dove, L.H. Pinto, F.W. Turek and J.S. Takahashi. Science 1994 264:719-725 6

Books

Featured Books Legend Featured Books

Handbook of Behavioral Neurobiology: Volume 12 Circadian Clocks

Takahashi, J.S., F.W. Turek and R.Y. Moore (Ed.) (2001). New York, Kluwer Academic/Plenum Publishing

Honors & Awards

  • National Academy of Medicine
    Member (2014)
  • Outstanding Scientific Achievement Award
    Sleep Research Society (2012)
  • National Academy of Sciences
    Member (2003)
  • W. Alden Spencer Award
    College of Physicians and Surgeons, Columbia University (2001)
  • American Academy of Arts and Sciences
    Fellow (2000)
  • 6th C.U. Ariens Kappers Award
    Netherlands Society for the Advancement of Natural Sciences, Medicine and Surgery (1995)
  • Honma Prize in Biological Rhythms Research
    Honma Foundation of Life Sciences (1986)

Professional Associations/Affiliations

  • Howard Hughes Medical Institute (2009)