Biography

Vikram Jakkamsetti is an Instructor in the Department of Neurology at UT Southwestern Medical Center. He works in Dr. Juan Pascual’s lab with a primary goal of exploring mechanistic links between energy metabolism and neuronal electrophysiology, for providing insights relevant to correcting seizures and intellectual disability in related pediatric encephalopathies. He also collaborates with lab colleagues on projects aiming to find the molecular, synaptic and neurophysiological underpinnings of rodent behavior impacted by mutations.

Vikram earned his medical degree (MBBS) and completed a residency in Internal Medicine (MD) at South Gujarat University in India. He then received an MS (Applied Cognition and Neuroscience) and a PhD (Cognition and Neuroscience) degree at The University of Texas at Dallas. During his PhD training in Dr. Michael Kilgard’s lab, he examined the impact of behavioral experience and pharmacology in inducing experience-dependent reorganization of cerebral cortex maps in rodent auditory cortex.

For postdoctoral training at UT Southwestern Medical Center in Dr. Kimberly Huber’s Lab, he studied how a brief novel experience primes only activated hippocampus neurons for subsequent synaptic plasticity, before moving to Dr. Juan Pascual’s lab.

Education

Undergraduate
South Gujarat University (1998), Medicine
Medical School
South Gujarat University (2002), Internal Medicine
Graduate School
University of Texas at Dallas (2008), Neuroscience

Research Interest

  • Behavioral Learning and Synaptic Plasticity
  • Energy Metabolism and Epilepsy
  • Machine Learning Applications in Neuroscience/Neurology
  • Systems/Cellular/Synaptic Neurophysiology
  • Translational Neuroscience

Publications

Featured Publications LegendFeatured Publications

Recording of pig neuronal activity in the comparative context of the awake human brain.
Dobariya A, El Ahmadieh TY, Good LB, Hernandez-Reynoso AG, Jakkamsetti V, Brown R, Dunbar M, Ding K, Luna J, Kallem RR, Putnam WC, Shelton JM, Evers BM, Azami A, Geramifard N, Cogan SF, Mickey B, Pascual JM, Sci Rep 2022 Sep 12 1 15503
Increased glycine contributes to synaptic dysfunction and early mortality in Nprl2 seizure model.
Dentel B, Angeles-Perez L, Ren C, Jakkamsetti V, Holley AJ, Caballero D, Oh E, Gibson J, Pascual JM, Huber KM, Tu BP, Tsai PT, iScience 2022 May 25 5 104334
Metabolic modulation of synaptic failure and thalamocortical hypersynchronization with preserved consciousness in Glut1 deficiency (in press)
Karthik Rajasekaran*, Qian Ma*, Levi B. Good*, Gauri Kathote, Vikram Jakkamsetti, Peiying Liu, Adrian Avila, Sharon Primeaux, Julio Enciso Alva, Kia H. Markussen, Isaac Marin-Valencia, Deepa Sirsi, Peter M. S. Hacker, Matthew S. Gentry, Jianzhong Su, Hanzhang Lu, Juan M. Pascual Science Translational Medicine 2022
Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice.
Stoodley CJ, D'Mello AM, Ellegood J, Jakkamsetti V, Liu P, Nebel MB, Gibson JM, Kelly E, Meng F, Cano CA, Pascual JM, Mostofsky SH, Lerch JP, Tsai PT Nat. Neurosci. 2017 Dec 20 12 1744-1751
Oxidation of [U-(13) C]glucose in the human brain at 7T under steady state conditions.
Cheshkov S, Dimitrov IE, Jakkamsetti V, Good L, Kelly D, Rajasekaran K, DeBerardinis RJ, Pascual JM, Sherry AD, Malloy CR Magn Reson Med 2017 Jan

Books

Featured Books Legend Featured Books

Auditory Environment, Stress, and Brain Plasticity. In The Neurobiology of Stress: an Evolutionary Approach

Nichols JA, Bose M, Jakkamsetti VP, Kilgard MP, Atzori M. (2007). Research Signpost

Pyruvate Dehydrogenase, Pyruvate Carboxylase,Krebs Cycle and Mitochondrial Transport Disorders. In Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, 6th Edition, Volume 1

Jakkamsetti V, Marin-Valencia I, Ma Q, Pascual JM (2020). Elsevier

Professional Associations/Affiliations

  • Society for Neuroscience (2004)
  • Association of Physicians of Gujarat (2002)