Benjamin Greenberg, M.D.

Dr. Benjamin Greenberg received his Bachelor of Arts degree from Johns Hopkins University and his Masters Degree in Molecular Microbiology and Immunology from the Johns Hopkins School of Public Health in Baltimore, Maryland. He attended medical school at Baylor College of Medicine in Houston, Texas. Then, he completed an internship in medicine at Rush Presbyterian-St. Lukes Medical Center in Chicago, Illinois before going on to his residency in neurology at The Johns Hopkins Hospital in Baltimore, MD. He then joined the faculty within the division of neuroimmunology at Hopkins and became the co-director of the Transverse Myelitis Center and director of the Encephalitis Center. In January of 2009 he was recruited to the faculty at the University of Texas Southwestern Medical Center where he was named Deputy Director of the Multiple Sclerosis Program and Director of the new Transverse Myelitis and Neuromyelitis Optica Program. That same year he established the Pediatric Demyelianting Disease Program at Children’s Medical Center Dallas.

Dr. Greenberg is recognized internationally as an expert in rare autoimmune disorders of the central nervous system (e.g. transverse myelitis, neuromyelitis optica, ADEM and autoimmune encephalitis). He splits his clinical time between seeing both adult and pediatric patients. He routinely consults on the inpatient units of University Hospital, Zale Lipshy, Parkland and Children’s. His research interests are in both the diagnosis and treatment of transverse myelitis, neuromyelitis optica, encephalitis, multiples sclerosis and infections of the nervous system. He is actively involved in developing better ways to diagnose and prognosticate for patients with these disorders. He has led an effort to improve biorepository development and has created uniform protocols for sample handling and analysis. As part of this initiative his research has identified novel biomarkers that may be able to distinguish between patients with various neurologic disorders. He also coordinates Phase 1, Phase 2 and Phase 3 trials that study new treatments to prevent neurologic damage and restore function to those who have already been affected. He currently serves as the Vice Chair for Clinical and Translational Research for the Department of Neurology.

Medical School

Baylor College of Medicine (2001)

Internship

Rush-Presbyterian-St. Lukes Med Ctr - GME (2002), Internal Medicine

Residency

Johns Hopkins School of Medicine (2005), Neurology

• Acute Disseminated Encephalomyelitis (ADEM)
• Acute Flaccid Myelitis
• anti-MOG Antibody Associated Disease
• anti-NMDAR Antibody Encephalitis
• Autoimmune Encephalitis
• Biomarkers of Disease
• Clinical Treatment Trials
• Multiple Sclerosis
• Neuromyelitis Optica
• Optic Neuritis
• Transverse Myelitis

Featured Publications

Gene-environment interactions increase the risk of paediatric-onset multiple sclerosis associated with household chemical exposures.

Nasr Z, Schoeps VA, Ziaei A, Virupakshaiah A, Adams C, Casper TC, Waltz M, Rose J, Rodriguez M, Tillema JM, Chitnis T, Graves JS, Benson L, Rensel M, Krupp L, Waldman AT, Weinstock-Guttman B, Lotze T, Greenberg B, Aaen G, Mar S, Schreiner T, Hart J, Simpson-Yap S, Mesaros C, Barcellos LF, Waubant E, J Neurol Neurosurg Psychiatry 2023 Jul 94 7 518-525

A place for biosimilars in the changing multiple sclerosis treatment landscape.

Greenberg B, Giovannoni G, Mult Scler Relat Disord 2023 Jun 77 104841

Subclinical optic neuritis in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease.

Nguyen L, Wang CX, Conger DL, Sguigna PV, Singh S, Greenberg BM, Mult Scler Relat Disord 2023 Jun 76 104802

Rare and low-frequency coding genetic variants contribute to pediatric-onset multiple sclerosis.

Horton MK, Shim JE, Wallace A, Graves JS, Aaen G, Greenberg B, Mar S, Wheeler Y, Weinstock-Guttman B, Waldman A, Schreiner T, Rodriguez M, Tillema JM, Chitnis T, Krupp L, Casper TC, Rensel M, Hart J, Quach HL, Quach DL, Schaefer C, Waubant E, Barcellos LF, Mult Scler 2023 Apr 29 4-5 505-511

Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity.

Shinoda K, Li R, Rezk A, Mexhitaj I, Patterson KR, Kakara M, Zuroff L, Bennett JL, von Büdingen HC, Carruthers R, Edwards KR, Fallis R, Giacomini PS, Greenberg BM, Hafler DA, Ionete C, Kaunzner UW, Lock CB, Longbrake EE, Pardo G, Piehl F, Weber MS, Ziemssen T, Jacobs D, Gelfand JM, Cross AH, Cameron B, Musch B, Winger RC, Jia X, Harp CT, Herman A, Bar-Or A, Proc Natl Acad Sci U S A 2023 Jan 120 3 e2207291120

Disease associations of excessive daytime sleepiness in multiple sclerosis: A prospective study.

Sguigna PV, Toranian S, Tardo LM, Blackburn KM, Horton LA, Conger D, Meltzer E, Hogan RN, McCreary MC, Zee PC, Takahashi JS, Greenberg BM, Mult Scler J Exp Transl Clin 2023 9 1 20552173231159560

Increased Prevalence of Familial Autoimmune Disease in Children With Opsoclonus-Myoclonus Syndrome.

Santoro JD, Kerr LM, Codden R, Casper TC, Greenberg BM, Waubant E, Kong SW, Mandl KD, Gorman MP, Neurol Neuroimmunol Neuroinflamm 2021 Nov 8 6

Familial History of Autoimmune Disorders Among Patients With Pediatric Multiple Sclerosis.

Greenberg BM, Casper TC, Mar SS, Ness JM, Plumb P, Liang S, Goyal M, Weinstock-Guttman B, Rodriguez M, Aaen GS, Belman A, Barcellos LF, Rose JW, Gorman MP, Benson LA, Candee M, Chitnis T, Harris YC, Kahn IL, Roalstad S, Hart J, Lotze TE, Rensel M, Rubin JP, Schreiner TL, Tillema JM, Waldman AT, Krupp L, Graves J, Drake K, Waubant E, Neurol Neuroimmunol Neuroinflamm 2021 09 8 5

Molecular Level Characterization of Circulating Aquaporin-4 Antibodies in Neuromyelitis Optica Spectrum Disorder.

Li J, Bazzi SA, Schmitz F, Tanno H, McDaniel JR, Lee CH, Joshi C, Kim JE, Monson N, Greenberg BM, Hedfalk K, Melamed E, Ippolito GC, Neurol Neuroimmunol Neuroinflamm 2021 Jul 8 5

In Depth Evaluation of a Case of Presumed Myocarditis Following the Second Dose of COVID-19 mRNA Vaccine.

Muthukumar A, Narasimhan M, Li QZ, Mahimainathan L, Hitto I, Fuda F, Batra K, Jiang X, Zhu C, Schoggins J, Cutrell JB, Croft CL, Khera A, Drazner MH, Grodin JL, Greenberg BM, Mammen PPA, Morrison SJ, de Lemos JA, Circulation 2021 Jun

 Featured Books

Myelopathy: A Guide to Diagnosis and Treatment

Benjamin Greenberg (Ed.) (2022).

• D Magazine Best Doctors in Dallas
  (2023)
• D Magazine Best Doctors in Dallas
  (2022)
• UT Southwestern Medical School Teaching Award
  (2022)
• D Magazine Best Doctors in Dallas
  (2021)
• UT Southwestern Medical School Teaching Award
  (2021)
• D Magazine Best Doctors in Dallas
  (2020)
• UT Southwestern Medical School Teaching Award
  (2020)
• D Magazine Best Doctors in Dallas
  (2019)
• UT Southwestern Medical School Teaching Award
  (2019)
• D Magazine Best Doctors in Medicine
  (2018)
• UT Southwestern Medical School Teaching Award
  (2018)
• D Magazine Best Doctors in Dallas
  (2017)
• UT Southwestern Medical School Teaching Award
  (2017)
• D Magazine Best Doctors in Dallas
  (2016)
• University of Texas Southwestern Academy of Teachers
  (2016)
• UT Southwestern Medical School Teaching Award
  (2016)
• University of Texas Board of Regents Teaching Award
  (2015)
• UT Southwestern Medical School Teaching Award
  (2015)
• UT Southwestern Medical School Teaching Award
  (2014)
• UT Southwestern Medical School Teaching Award
  (2013)
• UT Southwestern Medical School Teaching Award
  (2012)
• Fred Baskin Investigator Award
  Research Award (2011)
• UT Southwestern Medical School Teaching Award
  (2011)
• UT Southwestern Medical School Teaching Award
  (2010)
• UT Southwestern Neurology Trephined Cranium Teaching Award
  (2010)
• Accelerated Cure Project Physician of Distinction Award
  (2009)
• UT Southwestern Medical School Teaching Award
  (2009)
• Frank Ford
  Depart of Neurology Teaching Award (2008)
• Guy McKhann
  Resident Teaching Award (2005)
• Service Award From Maryland
  Multiple Sclerosis Society (2004)
• Intern of the Year Award
  Rush Internal Medicine (2002)
• Alpha Omega Alpha Honor Society, Baylor College of Medicine
  (2001)

• American Academy of Neurology (2002)
• American Neurological Association (2014)
• International Society for Biological and Environmental Repositories (2009)
• Siegel Rare Neuroimmune Association (2004)