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Benjamin Greenberg, M.D.

Benjamin Greenberg, M.D.

Titles and Appointments

Vice Chair of Clinical & Translational Research

Professor

Endowed Title
Cain Denius Scholar in Mobility Disorders; Distinguished Teaching Professor
School
Medical School
Department
Neurology | Pediatrics

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For more information on the doctor and patient care, please visit the clinical profile.

  • Biography

    Joined UT Southwestern: 2009

    Clinical Interests: Dr. Greenberg is recognized internationally as an expert in rare autoimmune disorders of the central nervous system (e.g. transverse myelitis, neuromyelitis optica, ADEM, and autoimmune encephalitis). He splits his clinical time between seeing both adult and pediatric patients. He routinely consults on the inpatient units of Clements University Hospital, Parkland, and Children’s.

    Research: His research interests are in both the diagnosis and treatment of transverse myelitis, neuromyelitis optica, encephalitis, multiple sclerosis, and infections of the nervous system. He is actively involved in developing better ways to diagnose and prognosticate for and treat patients with these disorders. He has led an effort to improve biorepository development and has created uniform protocols for sample handling and analysis. As part of this initiative, his research has identified novel biomarkers that may be able to distinguish between patients with various neurologic disorders. He also coordinates Phase 1, Phase 2, and Phase 3 trials that study new treatments to prevent neurologic damage and restore function to those who have already been affected.

    Leadership: He currently serves as the Vice Chair for Clinical and Translational Research for the Department of Neurology. When he joined UT Southwestern, he was named Deputy Director of the Multiple Sclerosis Program and Director of the new Transverse Myelitis and Neuromyelitis Optica Program. That same year he established the Pediatric Demyelianting Disease Program at Children’s Medical Center Dallas.

    Background: Dr. Benjamin Greenberg received his Bachelor of Arts degree from Johns Hopkins University and his Masters Degree in Molecular Microbiology and Immunology from the Johns Hopkins School of Public Health in Baltimore, Maryland. He attended medical school at Baylor College of Medicine in Houston, Texas. Then, he completed an internship in medicine at Rush Presbyterian-St. Lukes Medical Center in Chicago, Illinois before going on to his residency in neurology at The Johns Hopkins Hospital in Baltimore, MD. He then joined the faculty within the Division of Neuroimmunology at Hopkins and became the co-director of the Transverse Myelitis Center and director of the Encephalitis Center. In January of 2009 he was recruited to the faculty at the University of Texas Southwestern Medical Center.

  • Education
    Medical School
    Baylor College of Medicine (2001)
    Internship
    Rush-Presbyterian-St. Lukes Med Ctr - GME (2002), Internal Medicine
    Residency
    Johns Hopkins School of Medicine (2005), Neurology
  • Research Interest
    • Acute Disseminated Encephalomyelitis (ADEM)
    • Acute Flaccid Myelitis
    • anti-MOG Antibody Associated Disease
    • anti-NMDAR Antibody Encephalitis
    • Autoimmune Encephalitis
    • Biomarkers of Disease
    • Clinical Treatment Trials
    • Multiple Sclerosis
    • Neuromyelitis Optica
    • Optic Neuritis
    • Transverse Myelitis
  • Publications
    Gaps and discordance in assessment of PIRA identified between HCPs and people with MS: Results of international surveys
    Greenberg B, Giovannoni G, Hellwig K, Dackiewicz M, Turley G, Oh J Multiple Sclerosis and Related Disorders 2025 Nov 103
    Clinical, Radiologic, and Optical Coherence Tomographic Features of Pediatric Acute Disseminated Encephalomyelitis: Comparison of Myelin Oligodendrocyte Glycoprotein Antibody–Positive and –Negative Cases
    Nguyen L, Singh S, Wang CX, Greenberg BM Pediatric Neurology 2025 Oct 171 86-91
    Long-Term Efficacy and Safety of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disorder From the SAkuraMoon Open-Label Extension Study
    Bennett JL, Fujihara K, Saiz A, Traboulsee AL, Greenberg BM, Weinshenker BG, Patti F, Kleiter I, Palace J, De Seze J, Evans R, Blondeau K, Klingelschmitt G, Vodopivec I, Rahim M, Yamamura T Neurology: Neuroimmunology and NeuroInflammation 2025 Sep 12
    SARS-CoV-2 vaccine failure rates and predictors of immune response in a diverse immunocompromised patient population
    Greenberg BM, Minna JD, Gerber DE, Hernandez RS, Monson N, Muthukumar A, Cassady K, Chio E, Hooper AT, Wipperman MF, Greenberg DE Vaccine 2025 Aug 62
    Delphi panel to understand the real-world occurrence and management of ofatumumab injection-related reactions among healthcare providers of people with relapsing multiple sclerosis
    Saidha S, Kramer J, Brown B, Brewer I, Chou JW, Graf M, Wilson R, Greenberg BM Multiple Sclerosis Journal - Experimental, Translational and Clinical 2025 Jul 11
    Analysis of infection rates in neuromyelitis optica spectrum disorder: Comparing satralizumab treatment in SAkuraMoon, post-marketing, and US-based health claims data
    Greenberg BM, Fujihara K, Weinshenker B, Patti F, Kleiter I, Bennett JL, Palace J, Blondeau K, Burdeska A, Ngwa I, Klingelschmitt G, Triyatni M, Yamamura T Multiple Sclerosis and Related Disorders 2025 Jul 99
    Correction to: The Evolution of Anti-CD20 Treatment for Multiple Sclerosis: Optimization of Antibody Characteristics and Function (CNS Drugs, (2025), 39, 6, (545-564), 10.1007/s40263-025-01182-8)
    Cree BA, Berger JR, Greenberg B CNS Drugs 2025 Jul 39 721-724
    The Evolution of Anti-CD20 Treatment for Multiple Sclerosis: Optimization of Antibody Characteristics and Function
    Cree BA, Berger JR, Greenberg B CNS Drugs 2025 Jun 39 545-564
    Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Associated With Rhabdomyolysis: A Case Report
    Nguyen L, Strozzi I, Hegde S, Greenberg BM Pediatric Neurology 2025 Apr 165 40-42
    Astrocytic stress response is induced by exposure to astrocyte-binding antibodies expressed by plasmablasts from pediatric patients with acute transverse myelitis
    Smith C, Telesford KM, Piccirillo SG, Licon-Munoz Y, Zhang W, Tse KM, Rivas JR, Joshi C, Shah DS, Wu AX, Trivedi R, Christley S, Qian Y, Cowell LG, Scheuermann RH, Stowe AM, Nguyen L, Greenberg BM, Monson NL Journal of Neuroinflammation 2024 Dec 21
  • Books

    Featured 

    Myelopathy: A Guide to Diagnosis and Treatment

    Benjamin Greenberg (Ed.) (2022).

  • Honors & Awards
    • D Magazine Best Doctors in Dallas
      (2023)
    • D Magazine Best Doctors in Dallas
      (2022)
    • UT Southwestern Medical School Teaching Award
      (2022)
    • D Magazine Best Doctors in Dallas
      (2021)
    • UT Southwestern Medical School Teaching Award
      (2021)
    • D Magazine Best Doctors in Dallas
      (2020)
    • UT Southwestern Medical School Teaching Award
      (2020)
    • D Magazine Best Doctors in Dallas
      (2019)
    • UT Southwestern Medical School Teaching Award
      (2019)
    • D Magazine Best Doctors in Medicine
      (2018)
    • UT Southwestern Medical School Teaching Award
      (2018)
    • D Magazine Best Doctors in Dallas
      (2017)
    • UT Southwestern Medical School Teaching Award
      (2017)
    • D Magazine Best Doctors in Dallas
      (2016)
    • University of Texas Southwestern Academy of Teachers
      (2016)
    • UT Southwestern Medical School Teaching Award
      (2016)
    • University of Texas Board of Regents Teaching Award
      (2015)
    • UT Southwestern Medical School Teaching Award
      (2015)
    • UT Southwestern Medical School Teaching Award
      (2014)
    • UT Southwestern Medical School Teaching Award
      (2013)
    • UT Southwestern Medical School Teaching Award
      (2012)
    • Fred Baskin Investigator Award
      Research Award (2011)
    • UT Southwestern Medical School Teaching Award
      (2011)
    • UT Southwestern Medical School Teaching Award
      (2010)
    • UT Southwestern Neurology Trephined Cranium Teaching Award
      (2010)
    • Accelerated Cure Project Physician of Distinction Award
      (2009)
    • UT Southwestern Medical School Teaching Award
      (2009)
    • Frank Ford
      Depart of Neurology Teaching Award (2008)
    • Guy McKhann
      Resident Teaching Award (2005)
    • Service Award From Maryland
      Multiple Sclerosis Society (2004)
    • Intern of the Year Award
      Rush Internal Medicine (2002)
    • Alpha Omega Alpha Honor Society, Baylor College of Medicine
      (2001)
  • Professional Associations/Affiliations
    • American Academy of Neurology (2002)
    • American Neurological Association (2014)
    • International Society for Biological and Environmental Repositories (2009)
    • Siegel Rare Neuroimmune Association (2004)