Biography

Since 2021, Kimberly Reynolds has been appointed as an Assistant Professor in the Lyda Hill Department of Bioinformatics. Since 2014, she is also a member of the Cecil H. and Ida Green Center of Systems Biology, and the Department of Biophysics. Prior to joining the UTSW faculty, she completed a PhD in biophysics at UC Berkeley with Dr. Tracy Handel, where she studied the computational design of protein-protein interfaces. As a postdoctoral researcher, she developed a model for the evolution of new allosteric regulation and experimentally tested the idea of allosteric "hot spots" with Dr. Rama Ranganathan.

Research Interest
  • Evolution and engineering of cellular systems
  • Protein regulation and inter-protein communication
  • Statistical analysis of genomes and prediction of functional interactions between genes

Publications

Featured Publications LegendFeatured Publications

Structurally distributed surface sites tune allosteric regulation.
McCormick JW, Russo MAX, Thompson S, Blevins A, Reynolds KA Elife 2021 10 e68346
A simplified strategy for titrating gene expression reveals new relationships between genotype, environment, and bacterial growth.
Mathis AD, Otto RM, Reynolds KA, Nucleic Acids Res 2020 Nov
Altered expression of a quality control protease in E. coli reshapes the in vivo mutational landscape of a model enzyme.
Thompson S, Zhang Y, Ingle C, Reynolds KA, Kortemme T, Elife 2020 07 9
A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism.
Schober AF, Mathis AD, Ingle C, Park JO, Chen L, Rabinowitz JD, Junier I, Rivoire O, Reynolds KA, Cell Rep 2019 Jun 27 11 3359-3370.e7
Engineering allosteric regulation in protein kinases.
Pincus D, Pandey JP, Feder ZA, Creixell P, Resnekov O, Reynolds KA Sci Signal 2018 Nov 11 555
High-Order Epistasis in Catalytic Power of Dihydrofolate Reductase Gives Rise to a Rugged Fitness Landscape in the Presence of Trimethoprim Selection.
Tamer YT, Gaszek IK, Abdizadeh H, Batur TA, Reynolds KA, Atilgan AR, Atilgan C, Toprak E, Mol. Biol. Evol. 2019 Jul 36 7 1533-1550
An evolution-based strategy for engineering allosteric regulation.
Pincus D, Resnekov O, Reynolds KA Phys Biol 2017 Apr 14 2 025002
Evolution-Based Functional Decomposition of Proteins.
Rivoire O, Reynolds KA, Ranganathan R PLoS Comput. Biol. 2016 Jun 12 6 e1004817
Hot spots for allosteric regulation on protein surfaces.
Reynolds KA, McLaughlin RN, Ranganathan R Cell 2011 Dec 147 7 1564-75

Honors & Awards
  • National Science Foundation CAREER award
    (2020-2025)
  • Outstanding Graduate Educator - UT Southwestern Academy of Teachers
    (2020-2020)
  • Data Driven Discovery Investigator, Gordon and Betty Moore Foundation
    (2014-2021)