Education

Undergraduate
Peking University (2003), Pharmacology
Graduate School
Peking University (2008), Physiology

Research Interest

  • Alzheimer's and Neurodegenerative Diseases
  • Atherosclerosis
  • Lipoprotein
  • Lipoprotein Receptor
  • Metabolic Syndrome

Publications

Featured Publications LegendFeatured Publications

Dietary Cholesterol Is Highly Associated with Severity of Hyperlipidemia and Atherosclerotic Lesions in Heterozygous LDLR-Deficient Hamsters.
Wang J, He K, Yang C, Lin X, Zhang X, Wang Y, Liu G, Xian X, Int J Mol Sci 2019 Jul 20 14
IL-33 in murine abdominal aortic aneurysm: a novel inflammatory mediator awaiting clinical translation
Shirling Tsai, Xunde Xian J Thorac Dis 2019 11 6 2181-2184
An interspecies study of lipid profiles and atherosclerosis in familial hypercholesterolemia animal models with low-density lipoprotein receptor deficiency.
He K, Wang J, Shi H, Yu Q, Zhang X, Guo M, Sun H, Lin X, Wu Y, Wang L, Wang Y, Xian X, Liu G, Am J Transl Res 2019 11 5 3116-3127
Reversal of ApoE4 induced recycling block as a novel prevention approach for Alzheimer's disease.
Xian X, Pohlkamp T, Durakoglugil MS, Wong CH, Beck JK, Lane-Donovan C, Plattner F, Herz J Elife 2018 Oct 7
Low density lipoprotein receptor-related protein-1 dysfunction synergizes with dietary cholesterol to accelerate steatohepatitis progression.
Hamlin AN, Chinnarasu S, Ding Y, Xian X, Herz J, Jaeschke A, Hui DY J. Biol. Chem. 2018 May
Loss of LCAT Activity in the Golden Syrian Hamster Elicits Pro-atherogenic Dyslipidemia and Enhanced Atherosclerosis.
Dong Z, Shi H, Zhao M, Zhang X, Huang W, Wang Y, Zheng L, Xian X, Liu G Metab. Clin. Exp. 2018 Mar
LDL Receptor Gene-ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia With Dominant Inheritance and Diet-induced Coronary Atherosclerosis.
Guo X, Gao M, Wang Y, Lin X, Yang L, Cong N, An X, Wang F, Qu K, Yu L, Wang Y, Wang J, Zhu H, Xian X, Liu G EBioMedicine 2017 Dec
LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis.
Xian X, Ding Y, Dieckmann M, Zhou L, Plattner F, Liu M, Parks JS, Hammer RE, Boucher P, Tsai S, Herz J Elife 2017 Nov 6
Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice.
Lane-Donovan C, Wong WM, Durakoglugil MS, Wasser CR, Jiang S, Xian X, Herz J J. Neurosci. 2016 Sep 36 39 10141-50
Low-Density Lipoprotein Receptor-Related Protein-1 Protects Against Hepatic Insulin Resistance and Hepatic Steatosis.
Ding Y, Xian X, Holland WL, Tsai S, Herz J EBioMedicine 2016 May 7 135-145

Professional Associations/Affiliations

  • American Physiological Society (2011)
  • Society of Neuroscience (2008)