Michael Dellinger, Ph.D.

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Michael Dellinger, Ph.D., received his B.S. and Ph.D. degrees in Molecular and Cellular Biology from the University of Arizona. Dr. Dellinger’s training in lymphology began while he was a graduate student in the laboratories of Drs. Marlys Witte and Robert Erickson. As a graduate student, he investigated the molecular mechanisms controlling the development of the lymphatic vasculature and the genetic underpinnings of human diseases caused by errors in this essential process.

After completing his graduate work, he joined Rolf Brekken’s laboratory at UT Southwestern Medical Center. In Dr. Brekken’s laboratory he studied the role of the VEGF-A/VEGFR2 pathway in promoting developmental and tumor lymphangiogenesis.

In 2014, Dr. Dellinger became an Assistant Professor in the Department of Surgery at UT Southwestern Medical Center. The research in his laboratory is focused on developing animal models of lymphatic anomalies and using these models to identify novel therapies to treat patients. Additionally, his laboratory studies the molecular mechanisms controlling developmental and tumor lymphangiogenesis.  

Undergraduate

University of Arizona (2002), Molecular & Cell Biology

Graduate School

University of Arizona (2008), Molecular & Cell Biology

• Development of the Lymphatic Vasculature
• Gorham-Stout disease
• Lymphangiogenesis
• Lymphangiomatosis/Generalized Lymphatic Anomaly
• Lymphatic Malformation
• Lymphedema
• Tumor Lymphangiogenesis

Featured Publications

cause generalized lymphatic anomaly.

Rodriguez-Laguna L, Agra N, Ibañez K, Oliva-Molina G, Gordo G, Khurana N, Hominick D, Beato M, Colmenero I, Herranz G, Torres Canizalez JM, Rodríguez Pena R, Vallespín E, Martín-Arenas R, Del Pozo Á, Villaverde C, Bustamante A, Ayuso C, Lapunzina P, Lopez-Gutierrez JC, Dellinger MT, Martinez-Glez V J. Exp. Med. 2019 Feb 216 2 407-418

Impaired meningeal lymphatic vessel development worsens stroke outcome.

Yanev P, Poinsatte K, Hominick D, Khurana N, Zuurbier KR, Berndt M, Plautz EJ, Dellinger MT, Stowe AM J. Cereb. Blood Flow Metab. 2019 Jan 271678X18822921

VEGF-C promotes the development of lymphatics in bone and bone loss.

Hominick D, Silva A, Khurana N, Liu Y, Dechow PC, Feng JQ, Pytowski B, Rutkowski JM, Alitalo K, Dellinger MT Elife 2018 Apr 7

Identification of Gene Expression Differences between Lymphangiogenic and Non-Lymphangiogenic Non-Small Cell Lung Cancer Cell Lines.

Regan E, Sibley RC, Cenik BK, Silva A, Girard L, Minna JD, Dellinger MT PLoS ONE 2016 11 3 e0150963

Viewpoints on vessels and vanishing bones in Gorham-Stout disease.

Dellinger MT, Garg N, Olsen BR Bone 2014 Jun 63C 47-52

Vascular endothelial growth factor receptor-2 promotes the development of the lymphatic vasculature.

Dellinger MT, Meadows SM, Wynne K, Cleaver O, Brekken RA PLoS ONE 2013 8 9 e74686

Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice.

Dellinger M, Hunter R, Bernas M, Gale N, Yancopoulos G, Erickson R, Witte M Dev. Biol. 2008 Jul 319 2 309-20

Chy-3 mice are Vegfc haploinsufficient and exhibit defective dermal superficial to deep lymphatic transition and dermal lymphatic hypoplasia.

Dellinger MT, Hunter RJ, Bernas MJ, Witte MH, Erickson RP Dev. Dyn. 2007 Aug 236 8 2346-55

Cyclooxygenase-2 inhibition potentiates the efficacy of vascular endothelial growth factor blockade and promotes an immune stimulatory microenvironment in preclinical models of pancreatic cancer.

Zhang Y, Kirane A, Huang H, Sorrelle NB, Burrows FJ, Dellinger MT, Brekken RA Mol. Cancer Res. 2018 Oct

Lymphangiogenesis, lymphatic systemomics, and cancer: context, advances and unanswered questions.

Dellinger MT, Witte MH Clin. Exp. Metastasis 2018 May

• Science Award from the Lymphangiomatosis & Gorham’s Disease Alliance
  (2018)
• Invited Speaker Selected by Graduate Students in the Cell Biology Program at the University of Oklahoma Health Science Center (April 5, 2017; Oklahoma City, OK)
  (2017)
• John Mulliken Award for Best Scientific Paper, 21st International Workshop on Vascular Anomalies
  (2016)
• NAVBO Outstanding Poster Award
  (2012)
• UTSW Department of Surgery Basic Science Award
  (2011)
• UTSW Department of Surgery Basic Science Award
  (2010)
• Lymphatic Research Foundation Award
  (2008)
• International Society of Lymphology Presidential Prize
  (2007)
• Lymphatic Research Foundation Award
  (2006)
• International Society of Lymphology Presidential Prize
  (2005)

• North American Vascular Biology Association (2012)
• International Society of Lymphology (2005)