Michael Dellinger, Ph.D. Associate Professor School Medical School Department Surgery | Hamon Center for Therapeutic Oncology Research | Molecular Biology Graduate Programs Genetics, Development and Disease Biography Dr. Michael Dellinger is an Associate Professor in the Departments of Surgery and Molecular Biology at UT Southwestern Medical Center. He is also the Director of Research for the Lymphatic Malformation Institute, a non-profit organization that funds research on complex lymphatic anomalies. Additionally, he works closely with The Lymphangiomatosis & Gorham’s Disease Alliance (LGDA), and he was the Research Leader for the LGDA’s Rare as One Project sponsored by the Chan-Zuckerberg Initiative (CZI). Dr. Dellinger completed his Ph.D. work at the University of Arizona and his postdoctoral studies at UT Southwestern Medical Center. His lab is focused on identifying novel treatments for complex lymphatic anomalies. Education Undergraduate University of Arizona (2002), Molecular & Cell Biology Graduate School University of Arizona (2008), Molecular & Cell Biology Research Interest Central conducting lymphatic anomaly Development of the Lymphatic Vasculature Generalized Lymphatic Anomaly Gorham-Stout disease Kaposiform lymphangiomatosis Lymphatic Malformation Lymphedema Publications Featured Publications Stepwise Ultra-pH-Sensitive Micelles Overcome a pKa Barrier for Systemic Lymph Node Delivery. Bennett ZT, Huang G, Dellinger MT, Sumer BD, Gao J, ACS Nano 2024 Jun Vegfc-expressing cells form heterotopic bone after musculoskeletal injury. Vishlaghi N, Guo L, Griswold-Wheeler D, Sun Y, Booker C, Crossley JL, Bancroft AC, Juan C, Korlakunta S, Ramesh S, Pagani CA, Xu L, James AW, Tower RJ, Dellinger M, Levi B, Cell Rep 2024 Apr 43 4 114049 Trametinib inhibits lymphatic vessel invasion of bone in a mouse model of Gorham-Stout disease. McCarter AL, Dellinger MT, J Vasc Anom (Phila) 2023 Dec 4 4 Hyperactive KRAS/MAPK signaling disrupts normal lymphatic vessel architecture and function. Fernandes LM, Tresemer J, Zhang J, Rios JJ, Scallan JP, Dellinger MT, Front Cell Dev Biol 2023 11 1276333 KRAS-driven model of Gorham-Stout disease effectively treated with trametinib. Homayun Sepehr N, McCarter AL, Helaers R, Galant C, Boon LM, Brouillard P, Vikkula M, Dellinger MT, JCI Insight 2021 Jun Lymphatics in bone arise from pre-existing lymphatics. Monroy M, McCarter AL, Hominick D, Cassidy N, Dellinger MT, Development 2020 04 147 21 Bone development and fracture healing is normal in mice that have a defect in the development of the lymphatic system. McCarter AL, Khalid A, Yi Y, Monroy M, Zhao H, Rios JJ, Dellinger MT, Lymphology 2020 53 4 162-171 Somatic activating mutations in PIK3CA cause generalized lymphatic anomaly Journal of experimental medicine 2019 216 407-418 VEGF-C promotes the development of lymphatics in bone and bone loss. Hominick D, Silva A, Khurana N, Liu Y, Dechow PC, Feng JQ, Pytowski B, Rutkowski JM, Alitalo K, Dellinger MT Elife 2018 Apr 7 Identification of Gene Expression Differences between Lymphangiogenic and Non-Lymphangiogenic Non-Small Cell Lung Cancer Cell Lines. Regan E, Sibley RC, Cenik BK, Silva A, Girard L, Minna JD, Dellinger MT PLoS ONE 2016 11 3 e0150963 Results 1-10 of 35 1 2 3 4 Next Last Honors & Awards Science Award from the Lymphangiomatosis & Gorhams Disease Alliance (2018) Invited Speaker Selected by Graduate Students in the Cell Biology Program at the University of Oklahoma Health Science Center (April 5, 2017; Oklahoma City, OK) (2017) John Mulliken Award for Best Scientific Paper, 21st International Workshop on Vascular Anomalies (2016) NAVBO Outstanding Poster Award (2012) UTSW Department of Surgery Basic Science Award (2011) UTSW Department of Surgery Basic Science Award (2010) Lymphatic Research Foundation Award (2008) International Society of Lymphology Presidential Prize (2007) Lymphatic Research Foundation Award (2006) International Society of Lymphology Presidential Prize (2005) Professional Associations/Affiliations International Society for the Study of Vascular Anomalies (2014) International Society of Lymphology (2005) North American Vascular Biology Association (2012)
