Biography

Dr. Daniel K. Podolsky became President of the University of Texas Southwestern Medical Center on September 1, 2008. He had previously been the Mallinckrodt Professor of Medicine at Harvard Medical School, the Chief of Gastroenterology at Massachusetts General Hospital, and the Chief Academic Officer of Partners HealthCare System. In that capacity, he oversaw the research enterprise and graduate medical education programs of its founding academic medical centers, Massachusetts General Hospital and Brigham and Women’s Hospital.

Dr. Podolsky received his undergraduate degree from Harvard College summa cum laude and his medical degree from Harvard Medical School, followed by residency training in Internal Medicine and a fellowship in Gastroenterology at Massachusetts General Hospital. He joined the faculty of Harvard Medical School and the staff of Massachusetts General Hospital in 1981; he was appointed Chief of Gastroenterology at Massachusetts General Hospital in 1989; and was named the Mallinckrodt Professor of Medicine at Harvard Medical School in 1998. Under his leadership, the GI Unit became one of the leading programs in the country, highly regarded for its dynamic research and training activities, in addition to its comprehensive program of clinical care in gastroenterology. Dr. Podolsky established an innovative Center for the Study of Inflammatory Bowel Disease in 1991, funded through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Digestive Disease Center program, and the Center has been a highly productive multidisciplinary research program, yielding many significant advances.

Dr. Podolsky’s own research interests have focused on the delineation of epithelial cell function. His laboratory has made significant contributions to understanding the mechanisms through which growth factors and cytokines regulate epithelial function and has provided important insights into the mechanisms of epithelial injury and repair. His laboratory has also identified and characterized the functional actions and molecular mechanisms of trefoil peptides, which are central to sustaining mucosal integrity and facilitating repair after injury has occurred. In recent years his laboratory has helped clarify the role of the intestinal epithelium as a component of the innate immune system, through the characterization of innate immune receptors and their functional role in this cell compartment. In conjunction with studies defining basic mechanisms regulating epithelial function, Dr. Podolsky’s laboratory has provided important insights into the role of these processes in intestinal inflammatory diseases, most especially the inflammatory bowel diseases.

Dr. Podolsky is the author of more than 300 original research and review articles. He is the past editor-in-chief of the journal Gastroenterology. He served as President of the American Gastroenterological Association and was the recipient of its Julius Freidenwald Award in 2009. He is also a member of the National Academy of Medicine (formerly the Institute of Medicine of the National Academy of Sciences).

Education

Medical School
Harvard Medical School (1978)
Internship
Massachusetts General Hospital (1979), Internal Medicine
Residency
Massachusetts General Hospital (1980), Internal Medicine
Fellowship
Massachusetts General Hospital (1982), Gastroenterology

Research Interest

  • Epithelial Cell Biology
  • Inflammatory Bowel Disease
  • Innate Immunity
  • Mucosal Biology
  • Trefoil Proteins

Publications

Featured Publications LegendFeatured Publications

Intestinal trefoil factor confers colonic epithelial resistance to apoptosis.
Taupin DR, Kinoshita K, Podolsky DK Proc. Natl. Acad. Sci. U.S.A. 2000 Jan 97 2 799-804
Infliximab for the treatment of fistulas in patients with Crohn's disease.
Present DH, Rutgeerts P, Targan S, Hanauer SB, Mayer L, van Hogezand RA, Podolsky DK, Sands BE, Braakman T, DeWoody KL, Schaible TF, van Deventer SJ N. Engl. J. Med. 1999 May 340 18 1398-405
The trefoil gene family are coordinately expressed immediate-early genes: EGF receptor- and MAP kinase-dependent interregulation.
Taupin D, Wu DC, Jeon WK, Devaney K, Wang TC, Podolsky DK J. Clin. Invest. 1999 May 103 9 R31-8
Physician specialty and variations in the cost of treating patients with acute upper gastrointestinal bleeding.
Quirk DM, Barry MJ, Aserkoff B, Podolsky DK Gastroenterology 1997 Nov 113 5 1443-8
Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor.
Mashimo H, Wu DC, Podolsky DK, Fishman MC Science 1996 Oct 274 5285 262-5
Molecular cloning of the rat intestinal trefoil factor gene. Characterization of an intestinal goblet cell-associated promoter.
Sands BE, Ogata H, Lynch-Devaney K, deBeaumont M, Ezzell RM, Podolsky DK J. Biol. Chem. 1995 Apr 270 16 9353-61
Identification and characterization of rat intestinal trefoil factor: tissue- and cell-specific member of the trefoil protein family.
Suemori S, Lynch-Devaney K, Podolsky DK Proc. Natl. Acad. Sci. U.S.A. 1991 Dec 88 24 11017-21
Regulation of transforming growth factor expression in rat intestinal epithelial cell lines.
Suemori S, Ciacci C, Podolsky DK J. Clin. Invest. 1991 Jun 87 6 2216-21
Differential expression of transforming growth factors alpha and beta in rat intestinal epithelial cells.
Koyama SY, Podolsky DK J. Clin. Invest. 1989 May 83 5 1768-73

Honors & Awards

  • American Gastroenterological Association
    Julius Friedenwald Medal (2009)
  • American Gastroenterological Association
    Distinguished Achievement Award (2007)
  • American Gastroenterological Association
    President (2003)
  • National Institutes of Health
    MERIT Award (1998)

Professional Associations/Affiliations

  • American Federation for Medical Research
  • American Gastroenterological Association
  • American Society for Clinical Investigation
  • Association of American Physicians
  • National Academy of Medicine (formerly the Institute of Medicine of the National Academy of Sciences)