Deepa Sirsi, M.D., is a Pediatric Neurologist at Children’s Health. She currently serves as an Associate Professor of Pediatrics, and Neurology & Neurotherapeutics at UT Southwestern Medical Center. Dr. Sirsi is the Program Director for the Pediatric Epilepsy fellowship program at UT Southwestern Medical Center.

After graduating from Bangalore Medical College and Research Institute in India, Dr. Sirsi completed a pediatric residency at Newark Beth Israel Medical Center in New Jersey. Subsequently, she completed a pediatric neurology residency at New York-Presbyterian Weill Cornell Medical Center in New York and then went on to a neurophysiology fellowship at University Hospital for Albert Einstein College of Medicine, Montefiore Medical Center in New York. She came to UT Southwestern in 2008 and since then, has served in a number of leadership roles and has given many lectures on campus in addition to several guest lectures by invitation. She is currently a Fellow of the American Epilepsy Society (FAES).

Dr. Sirsi is currently involved with clinical trials for intractable epilepsy. Dr. Sirsi currently serves as the principal investigator for clinical trials in Lennox-Gastaut Syndrome and she co-investigates for research into dietary treatment of glucose transporter type 1 deficiency (G1D) among other anti-seizure medication trials for intractable epilepsy. Her clinical interests include pediatric genetic epilepsy syndromes, epilepsy surgery for medically intractable epilepsy, and dietary treatments for epilepsy.


Medical School
Bangalore Medical College, India (1999)
Newark Beth Israel Medical Center (2004), Pediatrics
New York Presbyterian Hospital/Cornell Campus (2007), Pediatric Neurology
Albert Einstein College of Medicine/Montefiore Medical Center (2008), Neurophysiology

Research Interest

  • Genetic Epilepsy Syndrome


Featured Publications LegendFeatured Publications

Spatially clustering de novo variants in CYFIP2, encoding the cytoplasmic FMRP interacting protein 2, cause intellectual disability and seizures.
Zweier M, Begemann A, McWalter K, Cho MT, Abela L, Banka S, Behring B, Berger A, Brown CW, Carneiro M, Chen J, Cooper GM, Finnila CR, Guillen Sacoto MJ, Henderson A, Hüffmeier U, Joset P, Kerr B, Lesca G, Leszinski GS, McDermott JH, Meltzer MR, Monaghan KG, Mostafavi R, Õunap K, Plecko B, Powis Z, Purcarin G, Reimand T, Riedhammer KM, Schreiber JM, Sirsi D, Wierenga KJ, Wojcik MH, Papuc SM, Steindl K, Sticht H, Rauch A Eur. J. Hum. Genet. 2019 Jan
Evolution of EEG findings in children with autism spectrum disorder: A tertiary care centre?s clinical experience.
Thodeson D, Dowd D, Golla S, Evans P, Huang R, Sirsi D Journal of Psychology and Psychiatry (Online-Open Access Text) 2018 2 2 1-4
SYN1 Gene Mutation in a Child with Focal Epilepsy and Reflex Bathing Seizures
Sirsi D, Armstrong D, Muñoz-Bibiloni J, Redondo B, Park JY. J Pediatr Epilepsy 2017 6 2 119-124
Paroxysmal Choreoathetosis in a Child with SCN2A Mutation and Neonatal Seizures.
George N, Thodeson D, Park J, Sirsi D. Neurology & Neurosurgery 2017 4 4
De novo and inherited mutations in the X-linked gene CLCN4 are associated with syndromic intellectual disability and behavior and seizure disorders in males and females.
Palmer EE, Stuhlmann T, Weinert S, Haan E, Van Esch H, Holvoet M, Boyle J, Leffler M, Raynaud M, Moraine C, van Bokhoven H, Kleefstra T, Kahrizi K, Najmabadi H, Ropers HH, Delgado MR, Sirsi D, Golla S, Sommer A, Pietryga MP, Chung WK, Wynn J, Rohena L, Bernardo E, Hamlin D, Faux BM, Grange DK, Manwaring L, Tolmie J, Joss S, Cobben JM, Duijkers FA, Goehringer JM, Challman TD, Hennig F, Fischer U, Grimme A, Suckow V, Musante L, Nicholl J, Shaw M, Lodh SP, Niu Z, Rosenfeld JA, Stankiewicz P, Jentsch TJ, Gecz J, Field M, Kalscheuer VM Mol. Psychiatry 2016 Aug
Fosphenytoin-induced dyskinesias in an infant with Sturge-Weber syndrome.
Thodeson DM, Reiber DC, Dolce AM, Sirsi D Neurology 2016 Apr 86 16 1561-2
Does autoimmunity have a role in Myoclonic Astatic Epilepsy? A case report of Voltage Gated Potassium Channel mediated seizures. Does Autoimmunity have a Role in Myoclonic Astatic Epilepsy? A Case Report of Voltage Gated Potassium Channel Mediated Seizures.
Sirsi D, Dolce A, Greenberg BM, Thodeson D anncaserep 2016 1
Type II Cortical Dysplasia in Dominant Frontal Lobe Presenting as Gelastic Epilepsy.
Dubey D, Thodeson D, Dowling M, Sirsi D, Arnold S, Said R Pediatr. Neurol. 2015 Jul 53 1 97-8
The safety and tolerability of newer antiepileptic drugs in children and adolescents.
Kayani S, Sirsi D J Cent Nerv Syst Dis 2012 4 51-63
Is intranasal midazolam better than rectal diazepam for home management of acute seizures?
Sirsi D Arch. Neurol. 2011 Jan 68 1 120-1


Featured Books Legend Featured Books

Honors & Awards

  • Top Doctor in Plano, TX
    International Association of Healthcare Professionals (IAHCP) (2018)
  • Best Pediatric Specialists
    D Magazine (2017)
  • Best Doctors in Dallas
    D Magazine (2016)
  • Top Scholar Award
    Epilepsy Foundation (2007)
  • Intern of the Year Award
    Pediatrics, Newark Beth Israel Medical Center (2003)

Professional Associations/Affiliations

  • American Academy of Neurology (2011)
  • Fellow, American Epilepsy Society (2017)
  • Member, American Epilepsy Society (2008)