Stone Chen, Ph.D.

 Featured Publications

Structural basis for Retriever-SNX17 assembly and endosomal sorting.

Singla A, Boesch DJ, Fung HYJ, Ngoka C, Enriquez AS, Song R, Kramer DA, Han Y, Banarer E, Lemoff A, Juneja P, Billadeau DD, Bai X, Chen Z, Turer EE, Burstein E, Chen B, Nat Commun 2024 Nov 15 1 10193

Structural organization of the retriever-CCC endosomal recycling complex.

Boesch DJ, Singla A, Han Y, Kramer DA, Liu Q, Suzuki K, Juneja P, Zhao X, Long X, Medlyn MJ, Billadeau DD, Chen Z, Chen B, Burstein E, Nat Struct Mol Biol 2023 Dec

The intrinsically disordered cytoplasmic tail of a dendrite branching receptor uses two distinct mechanisms to regulate the actin cytoskeleton.

Kramer DA, Narvaez-Ortiz HY, Patel U, Shi R, Shen K, Nolen BJ, Roche J, Chen B, Elife 2023 Aug 12

Arf GTPase activates the WAVE regulatory complex through a distinct binding site.

Yang S, Tang Y, Liu Y, Brown AJ, Schaks M, Ding B, Kramer DA, Mietkowska M, Ding L, Alekhina O, Billadeau DD, Chowdhury S, Wang J, Rottner K, Chen B, Sci Adv 2022 Dec 8 50 eadd1412

Structures reveal a key mechanism of WAVE regulatory complex activation by Rac1 GTPase.

Ding B, Yang S, Schaks M, Liu Y, Brown AJ, Rottner K, Chowdhury S, Chen B, Nat Commun 2022 Sep 13 1 5444

A Dendritic Guidance Receptor Complex Brings Together Distinct Actin Regulators to Drive Efficient F-Actin Assembly and Branching.

Zou W, Dong X, Broederdorf TR, Shen A, Kramer DA, Shi R, Liang X, Miller DM, Xiang YK, Yasuda R, Chen B, Shen K Dev. Cell 2018 05 45 3 362-375.e3

Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites.

Chen B, Chou HT, Brautigam CA, Xing W, Yang S, Henry L, Doolittle LK, Walz T, Rosen MK Elife 2017 Sep 6

The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton.

Chen B, Brinkmann K, Chen Z, Pak CW, Liao Y, Shi S, Henry L, Grishin NV, Bogdan S, Rosen MK Cell 2014 Jan 156 1-2 195-207

CCDC22 mutations that impair COMMD binding cause attenuated 3C/Ritscher-Schinzel syndrome.

Singla A, Rogers C, Touma MJ, El-Najjar Y, Colley A, Boesch DJ, Billadeau DD, Gecz J, Chen B, Burstein E, BMC Med Genomics 2025 May 18 1 98

A novel dominant-negative variant of IRF8 in a mother and son: Clinical, phenotypic and biological characteristics.

Ham H, Isham CR, Ristagno EH, Correia C, Ennis SM, Kandasamy RK, Garapati K, Zhang C, Kohlhagen MC, Sadighi Akha E, Rodriguez-Quevedo MF, Schultz DF, Chen B, Boyce TG, Gregory SW, Kohorst MA, Dasari S, Murray DL, Halling KC, Kipp BR, Kumánovics A, Li H, Pandey A, Billadeau DD, Sadighi Akha AA, J Allergy Clin Immunol 2025 Mar