Biography

Fangyu Peng, M.D., is an Associate Professor of Radiology at UT Southwestern Medical Center and a member of its Nuclear Medicine Division. He also serves as the Director of Positron Emission Tomography (PET) Translational Imaging, and holds a secondary appointment in the Advanced Imaging Research Center. His clinical interests include general nuclear medicine, PET imaging, and computed tomography (CT), with a particular interest in oncology and neurology. 

Dr. Peng earned his medical degree at Jiangxi Medical College in Nanchang, China. He then earned a master’s degree in molecular virology at Chinese Academy of Preventive Medicine's Institute of Virology in Beijing. He earned a doctoral degree in microbiology and immunology at the University of South Florida College of Medicine in Tampa. He then completed a research fellowship program in hematopathology at Ball Memorial Hospital in Muncie, Indiana, before completing his residency in pathology at Upstate Medical University in Syracuse, New York. Dr. Peng then completed a residency in nuclear medicine at the University of Connecticut Health Center in Farmington, and in anatomic pathology at Hartford Hospital. He completed his formal training with a fellowship program in nuclear medicine and molecular imaging at the National Institutes of Health in Bethesda, Maryland.

Before being recruited in 2008 to enhance the Nuclear Medicine Division's translational research, Dr. Peng served as an Assistant Professor of Radiology and Pediatrics at Wayne State University School of Medicine in Detroit.

At UT Southwestern, he troubleshoots and improves imaging protocols, and actively participates in educational endeavors, in addition to his regular clinical responsibilities.

Dr. Peng focuses his research on inherited and acquired copper metabolism disorders in Wilson’s disease, Alzheimer’s disease, and traumatic brain injury, and investigates copper metabolism as a theranostic target for molecular imaging and cancer treatment. His research has been published in more than 50 peer-reviewed publications. He also invented and received a patent for intracellular trapping of radionuclides by enzyme-mediated reduction. 

Education

Medical School
Jiangxi Medical College (1982)
Other Post Graduate Training
University of South Florida (1994)
Graduate School
University of South Florida (1994), Medical Microbiology & Immunology
Fellowship
Ball Memorial Hospital (1996), Hematopathology
Residency
SUNY Upstate Medical University (1998), Pathology
Residency
University of Connecticut Health Center (2000), Nuclear Medicine
Residency
Hartford Hospital (2002), Anatomic Pathology
Fellowship
Warren Grant Magnuson Clinical Center - NIH (2003), Nuclear Medicine

Research Interest

  • Functional imaging of altered copper fluxes in Wilson's disease, Alzheimer's disease, and traumatic brain injury
  • Targeting copper metabolism for molecular cancer imaging and therapy

Publications

Featured Publications LegendFeatured Publications

Positron emission tomography for measurement of copper fluxes in live organisms.
Peng F Ann. N. Y. Acad. Sci. 2014 Mar
Knockdown of copper chaperone antioxidant-1 by RNA interference inhibits copper-stimulated proliferation of non-small cell lung carcinoma cells.
Cai H, Peng F Oncol. Rep. 2013 Apr
Positron emission tomography of copper metabolism in the Atp7b?/? knock-out mouse model of Wilson's disease.
Peng F, Lutsenko S, Sun X, Muzik O Mol Imaging Biol 2012 Feb 14 1 70-8
Positron Emission Tomography of Human Hepatocellular Carcinoma Xenografts in Mice Using Copper (II)-64 Chloride as a Tracer with Copper (II)-64 Chloride.
Zhang H, Cai H, Lu X, Muzik O, Peng F Acad Radiol 2011 Dec 18 12 1561-8
Imaging Copper Metabolism Imbalance in Atp7b (-/-) Knockout Mouse Model of Wilson's Disease with PET-CT and Orally Administered (64)CuCl (2).
Peng F, Lutsenko S, Sun X, Muzik O Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2011 Dec
Assessment of progression and treatment response of optic pathway glioma with positron emission tomography using alpha-[(11)C]methyl-L-tryptophan.
Peng F, Juhasz C, Bhambhani K, Wu D, Chugani DC, Chugani HT Mol Imaging Biol 2007 May-Jun 9 3 106-9
PET of human prostate cancer xenografts in mice with increased uptake of 64CuCl2.
Peng F, Lu X, Janisse J, Muzik O, Shields AF J. Nucl. Med. 2006 Oct 47 10 1649-52
Use of 2-deoxy-2-[F-18]-fluoro-D-glucose positron emission tomography to monitor therapeutic response by rhabdomyosarcoma in children: report of a retrospective case study.
Peng F, Rabkin G, Muzik O Clin Nucl Med 2006 Jul 31 7 394-7
Mouse extrahepatic hepatoma detected on MicroPET using copper (II)-64 chloride uptake mediated by endogenous mouse copper transporter 1.
Peng F, Liu J, Wu JS, Lu X, Muzik O Mol Imaging Biol 2005 Sep-Oct 7 5 325-9

Honors & Awards

  • Fellow
    American College of Nuclear Medicine (2019)
  • Chief Resident in Nuclear Medicine
    University of Connecticut Health Center (1999-2000)

Professional Associations/Affiliations

  • American Society of Neurochemistry (2017)
  • International Society to Advance Alzheimer¬ís Research and Treatment (2016)
  • International Society for Neurochemistry (2015)
  • American College of Nuclear Medicine (2014)
  • Society of Nuclear Medicine and Molecular Imaging (1998)