Biography

Fangyu Peng, M.D., is an Associate Professor of Radiology at UT Southwestern Medical Center and a member of its Nuclear Medicine Division. He also serves as the Director of Positron Emission Tomography (PET) Translational Imaging, and holds a secondary appointment in the Advanced Imaging Research Center. His clinical interests include general nuclear medicine, PET imaging, and computed tomography (CT), with a particular interest in oncology and neurology. 

Dr. Peng earned his medical degree at Jiangxi Medical College in Nanchang, China. He then earned a master’s degree in molecular virology at Chinese Academy of Preventive Medicine's Institute of Virology in Beijing. He earned a doctoral degree in microbiology and immunology at the University of South Florida College of Medicine in Tampa. He then completed a research fellowship program in hematopathology at Ball Memorial Hospital in Muncie, Indiana, before completing his residency in pathology at Upstate Medical University in Syracuse, New York. Dr. Peng then completed a residency in nuclear medicine at the University of Connecticut Health Center in Farmington, and in anatomic pathology at Hartford Hospital. He completed his formal training with a fellowship program in nuclear medicine and molecular imaging at the National Institutes of Health in Bethesda, Maryland.

Before being recruited in 2008 to enhance the Nuclear Medicine Division's translational research, Dr. Peng served as an Assistant Professor of Radiology and Pediatrics at Wayne State University School of Medicine in Detroit.

At UT Southwestern, he troubleshoots and improves imaging protocols, and actively participates in educational endeavors, in addition to his regular clinical responsibilities.

Dr. Peng focuses his research on inherited and acquired copper metabolism disorders in Wilson’s disease, Alzheimer’s disease, and traumatic brain injury, and investigates copper metabolism as a theranostic target for molecular imaging and cancer treatment. His research has been published in more than 50 peer-reviewed publications. He also invented and received a patent for intracellular trapping of radionuclides by enzyme-mediated reduction. 

Education

Medical School
Jiangxi Medical College (1982)
Graduate School
University of South Florida (1994), Medical Microbiology & Immunology
Fellowship
Ball Memorial Hospital (1996), Hematopathology
Residency
SUNY Upstate Medical University (1998), Pathology
Residency
University of Connecticut Health Center (2000), Nuclear Medicine
Residency
Hartford Hospital (2002), Anatomic Pathology
Fellowship
Warren Grant Magnuson Clinical Center - NIH (2003), Nuclear Medicine

Research Interest

  • Metabolic imaging of copper metabolism imbalance in Wilson's disease, Alzheimer's disease, and traumatic brain injury
  • Targeting copper metabolism for molecular cancer imaging and therapy

Publications

Featured Publications LegendFeatured Publications

Alteration of Copper Fluxes in Brain Aging: A Longitudinal Study in Rodent Using 64CuCl2-PET/CT.
Peng F, Xie F, Muzik O Aging Dis 2018 Feb 9 1 109-118
Radiopharmaceuticals for Assessment of Altered Metabolism and Biometal Fluxes in Brain Aging and Alzheimer's Disease with Positron Emission Tomography.
Xie F, Peng F J. Alzheimers Dis. 2017 Jun
Age-dependent changes of cerebral copper metabolism in Atp7b (-/-) knockout mouse model of Wilson's disease by [(64)Cu]CuCl2-PET/CT.
Xie F, Xi Y, Pascual JM, Muzik O, Peng F Metab Brain Dis 2017 Jan
Molecular imaging and therapy targeting copper metabolism in hepatocellular carcinoma.
Wachsmann J, Peng F World J. Gastroenterol. 2016 Jan 22 1 221-31
Detection of Increased 64Cu uptake in Traumatic Brain Injury with 64CuCl2-PET/CT.
Peng F, Muzik O, Gatson J, Kernie S, Diaz-Arrastia R J. Nucl. Med. 2015 Jun
Reduced 64Cu Uptake and Tumor Growth Inhibition by Knockdown of Human Copper Transporter 1 in Xenograft Mouse Model of Prostate Cancer.
Cai H, Wu JS, Muzik O, Hsieh JT, Lee RJ, Peng F J. Nucl. Med. 2014 Mar

Honors & Awards

  • Chief Resident in Nuclear Medicine
    University of Connecticut Health Center (1999-2000)

Professional Associations/Affiliations

  • American Society of Neurochemistry (2017)
  • International Society to Advance Alzheimer’s Research and Treatment (2016)
  • International Society for Neurochemistry (2015)
  • American College of Nuclear Medicine (2014)
  • Society of Nuclear Medicine and Molecular Imaging (1998)