Biography

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Dr. Lakshmi Raman serves as the Medical Director of the Extracorporeal Membrane Oxygenation (ECMO) program She has primarily focused her efforts on education and research apart from overseeing the clinical care of these patients.

Since ECMO is high-risk therapy with low probability events education is an integral part of running an ECMO program. We run a two day education course with hands on simulation for incoming fellows and specialists who assist in caring for the ECMO pump on a yearly basis and I oversee the curriculum. I also direct a 3-day National ECMO course once a year which has been endorsed by the Extra Corporeal Life Support Organization (ELSO) which is a parent organization and serve as the first course to be endorsed by ELSO and attended by participants across the Nation and Internationally.

My research focus has been to evaluate the neurological injury in patients who are on Extracorporeal life support, otherwise commonly referred to as Extracorporeal Membrane Oxygenation (ECMO). I have collaborated this work with biomedical engineers and scientists in the lab. I previously had funding through AHA association and recently funded through the Hartwell Foundation to carry on this work through my collaborators. I am also working with the bioinformatics group at UT to use machine learning help understand neurological injuries. This work is primarily done by critical care fellows and have been awarded the Lyda-Hill Award to do the study. With my role as the Medical Director of the ECMO program at Children’s Medical Center of Dallas I am interested in finding ways to predict neurological events on ECMO.

With my leadership and focus on ECMO, I have recently published my work that I have done both locally and nationally with ELSO community. I continue to present my work at National and International meetings.

I also serve as a reviewer for Neuroscience Letters, Journal of Pediatric Surgical Research, ASAIO and serve on the review committee for fellow clinical grants and abstracts with Pediatric Academic Society. I also serve on the editorial board for ASAIO. I have been appointed to the steering committee at ELSO to chair the protocols, guidelines and grant committee. I also serve on the National committee for education and scientific review with ELSO data registry.

Education

Medical School
University of Madras Medical College (1989)
Internship
State University New York Downstate (1998), Pediatrics
Residency
State University New York Downstate (2001), Pediatrics
Fellowship
University of Minnesota Medical School (2004), Pediatric Critical Care Medicine

Research Interest

  • ECMO
  • Near infrared spectroscopy
  • Traumatic brain injury

Publications

Featured Publications LegendFeatured Publications

Regional cerebral abnormalities measured by frequency-domain near-infrared spectroscopy in pediatric patients during extracorporeal membrane oxygenation.
Tian F, Jenks C, Potter D, Miles D, Raman L ASAIO J. 2016 Dec
Successful engraftment after hematopoietic stem cell transplantation with infusion of donor stem cells through the extracorporeal membrane oxygenation circuit.
Anton-Martin P, Darnell-Bowens C, Aquino VM, Jones T, Raman L Indian J Crit Care Med 2016 Oct 20 10 617-619
Year in Review 2015: Extracorporeal Membrane Oxygenation.
Raman L, Dalton HJ Respir Care 2016 Jul 61 7 986-91
Perinatal chronic hypoxia induces cortical inflammation, hypomyelination, and peripheral myelin-specific T cell autoreactivity.
Ortega SB, Kong X, Venkataraman R, Savedra AM, Kernie SG, Stowe AM, Raman L J. Leukoc. Biol. 2015 Jun
Erythropoietin-mediated neuroprotection in a pediatric mouse model of chronic hypoxia.
Chung E, Kong X, Goldberg MP, Stowe AM, Raman L Neurosci. Lett. 2015 Apr 597 54-59
Assessments of cerebral blood flow, hemodynamics and metabolism in patients on ECMO using TCD and NIRS
Tian F, Raman L, Golla S, Liu H. Biomedical Optics 2014 Apr
Pharmacological inhibition of the mTOR pathway impairs hippocampal development in mice.
Raman L, Kong X, Kernie SG Neurosci. Lett. 2013 Feb
The use of extracorporeal life support in adolescent amlodipine overdose.
Persad EA, Raman L, Thompson MT, Sheeran PW Indian J Crit Care Med 2012 Oct 16 4 204-6
Chronic hypoxia impairs murine hippocampal development and depletes the postnatal progenitor pool by attenuating Mammalian target of rapamycin signaling.
Raman L, Kong X, Gilley JA, Kernie SG Pediatr. Res. 2011 Aug 70 2 159-65
Effects of chronic hypoxia in developing rats on dendritic morphology of the CA1 subarea of the hippocampus and on fear-potentiated startle.
Raman L, Hamilton KL, Gewirtz JC, Rao R Brain Res. 2008 Jan 1190 167-74

Honors & Awards

  • Center of Excellence with special recognition of the ECMO team
    Extracorporeal Life Support Organization (ELSO) (2014)
  • Press Ganey Award for Outstanding Patient Care
    Children's Medical Center (2011)
  • Principal Investigator
    Minneapolis Medical Research Foundation (2007)
  • Principal Investigator
    Vikings ChildrenÂ’s Fund-Grand in aid (2004)
  • Co-investigator
    Center for Neurobehavioral Development Research Grant (2002)
  • Jay H. Fisher Memorial Award for excellence in teaching
    SUNY, Brooklyn (2001)
  • Sixth Annual Residents Night Award
    Academy of Medicine of Richmond, NY (2001)
  • Distinction in Surgery
    Universtiy of Madras (1988)
  • Distinction in Anatomy and Biochemistry
    Universtiy of Madras (1984)

Professional Associations/Affiliations

  • Extracorporeal Life Support Organization (2013)
  • Society of Pediatric Research (2008)
  • American Academy of Pediatrics (2000)