Ling Cai, Ph.D.

• Bioinformatics, data integration
• Cancer metabolism
• Inborn errors of metabolism
• Lung neoplasm

Featured Publications

Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer.

Cai L, Liu H, Huang F, Fujimoto J, Girard L, Chen J, Li Y, Zhang YA, Deb D, Stastny V, Pozo K, Kuo CS, Jia G, Yang C, Zou W, Alomar A, Huffman K, Papari-Zareei M, Yang L, Drapkin B, Akbay EA, Shames DS, Wistuba II, Wang T, Johnson JE, Xiao G, DeBerardinis RJ, Minna JD, Xie Y, Gazdar AF, Commun Biol 2021 Mar 4 1 314

Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells.

Chen PH, Cai L, Huffman K, Yang C, Kim J, Faubert B, Boroughs L, Ko B, Sudderth J, McMillan EA, Girard L, Chen D, Peyton M, Shields MD, Yao B, Shames DS, Kim HS, Timmons B, Sekine I, Britt R, Weber S, Byers LA, Heymach JV, Chen J, White MA, Minna JD, Xiao G, DeBerardinis RJ, Mol. Cell 2019 Sep

LCE: an open web portal to explore gene expression and clinical associations in lung cancer.

Cai L, Lin S, Girard L, Zhou Y, Yang L, Ci B, Zhou Q, Luo D, Yao B, Tang H, Allen J, Huffman K, Gazdar A, Heymach J, Wistuba I, Xiao G, Minna J, Xie Y, Oncogene 2019 04 38 14 2551-2564

Genomic regression analysis of coordinated expression.

Cai L, Li Q, Du Y, Yun J, Xie Y, DeBerardinis RJ, Xiao G Nat Commun 2017 Dec 8 1 2187

Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes.

Cai L, Sutter BM, Li B, Tu BP Mol. Cell 2011 May 42 4 426-37

Lung Cancer Computational Biology and Resources.

Cai L, Xiao G, Gerber D, Minna JD, Xie Y, Cold Spring Harb Perspect Med 2021 Nov

Assessing Consistency Across Functional Screening Datasets in Cancer Cells.

Cai L, Liu H, Minna JD, DeBerardinis RJ, Xiao G, Xie Y, Bioinformatics 2021 Jun

Metabolic impact of pathogenic variants in the mitochondrial glutamyl-tRNA synthetase EARS2.

Ni M, Black LF, Pan C, Vu H, Pei J, Ko B, Cai L, Solmonson A, Yang C, Nugent KM, Grishin NV, Xing C, Roeder E, DeBerardinis RJ, J Inherit Metab Dis 2021 Apr

Modular gene analysis reveals distinct molecular signatures for cutaneous lupus patient subsets.

Zhu JL, Tran LT, Smith M, Zheng F, Cai L, James JA, Guthridge JM, Chong BF, Br J Dermatol 2021 Jan

The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer.

Kim J, Lee HM, Cai F, Ko B, Yang C, Lieu EL, Muhammad N, Rhyne S, Li K, Haloul M, Gu W, Faubert B, Kaushik AK, Cai L, Kasiri S, Marriam U, Nham K, Girard L, Wang H, Sun X, Kim J, Minna JD, Unsal-Kacmaz K, DeBerardinis RJ, Nat Metab 2020 12 2 12 1401-1412