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Xiaorong Fu, Ph.D.

Xiaorong Fu, Ph.D.

Associate Professor

School
Medical School
Department
Center for Human Nutrition | Internal Medicine
Graduate Programs
Biological Chemistry
  • Education
    Undergraduate
    (1992), Chemistry
    Graduate School
    (2001), Chemistry
    Graduate School
    Tufts University (2005), Chemistry
  • Research Interest
    • Flux analysis
    • High-resolution mass spectrometry
    • LC-mass spectrometry based metabolomics
    • Stable isotope tracers
  • Publications

    Star Featured Publications

    In Vivo Estimation of Ketogenesis Using Metabolic Flux Analysis-Technical Aspects and Model Interpretation.
    Deja S, Kucejova B, Fu X, Browning JD, Young JD, Burgess S, Metabolites 2021 Apr 11 5
    Measurement of lipogenic flux by deuterium resolved mass spectrometry
    Xiaorong Fu, Stanislaw Deja, Justin A Fletcher, Norma N Anderson, Monika Mizerska, Gonçalo Vale, Jeffrey D Browning, Jay D Horton, Jeffrey G McDonald, Matthew A Mitsche, Shawn C Burgess Nat Commun 2021 1 12 3756
    In Vivo Estimation of Ketogenesis Using Metabolic Flux Analysis-Technical Aspects and Model Interpretation
    Deja S, Kucejova B, Fu X, Browning JD, Young JD, Burgess S Metabolites 2021 11(5) 28 279
    Hepatic deletion of Mboat7 (LPIAT1) causes activation of SREBP-1c and fatty liver
    Xia M, Chandrasekaran P, Rong S, Fu X, Mitsche MA J Lipid Res 2021 62 100031
    Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver.
    Fletcher JA, Deja S, Satapati S, Fu X, Burgess SC, Browning JD, JCI Insight 2019 Apr 5
    Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver.
    Cappel DA, Deja S, Duarte JAG, Kucejova B, Iñigo M, Fletcher JA, Fu X, Berglund ED, Liu T, Elmquist JK, Hammer S, Mishra P, Browning JD, Burgess SC, Cell Metab. 2019 Apr
    Targeted Determination of Tissue Energy Status by LC-MS/MS.
    Fu X, Deja S, Kucejova B, Duarte JAG, McDonald JG, Burgess SC, Anal. Chem. 2019 Apr
    The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity.
    Rauckhorst AJ, Gray LR, Sheldon RD, Fu X, Pewa AD, Feddersen CR, Dupuy AJ, Gibson-Corley KN, Cox JE, Burgess SC, Taylor EB Mol Metab 2017 Nov 6 11 1468-1479
    FGF19, FGF21, and an FGFR1/?-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia.
    Lan T, Morgan DA, Rahmouni K, Sonoda J, Fu X, Burgess SC, Holland WL, Kliewer SA, Mangelsdorf DJ Cell Metab. 2017 Oct
    Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.
    Kim CW, Addy C, Kusunoki J, Anderson NN, Deja S, Fu X, Burgess SC, Li C, Ruddy M, Chakravarthy M, Previs S, Milstein S, Fitzgerald K, Kelley DE, Horton JD Cell Metab. 2017 Aug 26 2 394-406.e6
  • Professional Associations/Affiliations
    • The American Society for Mass Spectrometry (2019)