Research Interest

  • CRISPR/Cas9 Screening
  • Host-Pathogen Interactions
  • Immunology
  • Norovirus
  • Virology


Featured Publications LegendFeatured Publications

Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine.
Lee S, Wilen CB, Orvedahl A, McCune BT, Kim KW, Orchard RC, Peterson ST, Nice TJ, Baldridge MT, Virgin HW Cell Host Microbe 2017 Oct 22 4 449-459.e4
A systematic exploration of the interactions between bacterial effector proteins and host cell membranes.
Weigele BA, Orchard RC, Jimenez A, Cox GW, Alto NM Nat Commun 2017 09 8 1 532
Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases.
Biering SB, Choi J, Halstrom RA, Brown HM, Beatty WL, Lee S, McCune BT, Dominici E, Williams LE, Orchard RC, Wilen CB, Yamamoto M, Coers J, Taylor GA, Hwang S Cell Host Microbe 2017 Jul 22 1 74-85.e7
Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells.
Martinez J, Cunha LD, Park S, Yang M, Lu Q, Orchard R, Li QZ, Yan M, Janke L, Guy C, Linkermann A, Virgin HW, Green DR Nature 2016 Apr
Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival.
Redmann V, Lamb CA, Hwang S, Orchard RC, Kim S, Razi M, Milam A, Park S, Yokoyama CC, Kambal A, Kreamalmeyer D, Bosch MK, Xiao M, Green K, Kim J, Pruett-Miller SM, Ornitz DM, Allen PM, Beatty WL, Schmidt RE, DiAntonio A, Tooze SA, Virgin HW Sci Rep 2016 Mar 6 23326
A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-?-Activated Human Cells.
Selleck EM, Orchard RC, Lassen KG, Beatty WL, Xavier RJ, Levine B, Virgin HW, Sibley LD MBio 2015 Sep 6 5 e01157-15

Professional Associations/Affiliations

  • Washington University School of Medicine (2013-2018)
  • UT Southwestern Medical Center (2008-2013)