Rui Chen, M.D., Ph.D.

Assistant Professor

Department: Internal Medicine


Dr. Chen is originally from China and received his M.D., Ph.D. degree from the Nanjing Medical  University in China. Drawn by the opportunity for the harmonious integration of molecular cardiology, cell biology, and molecular biology, he completed his postdoctoral fellowship at the UT southwestern Medical Center at Dallas. Dr. Chen brings to UTSW a strong background in molecular cardiology and molecular biology. He currently specializes in hypoxic stress signaling and chromatin remodeling. Dr. Chen’s interests outside of medicine include his family, sports, reading, and the great outdoors.


Medical School Nanjing University - China (2002), Medicine
Graduate School Nanjing University - China (2007), Cell Biology

Research Interests

  • Cancer metabolism
  • Chromatin remodeling
  • Mammalian signal transduction pathways that regulate the cellular response to ischemic injury


Featured Publications Legend

Featured Publications

Allosteric inhibition of hypoxia inducible factor-2 with small molecules.

Scheuermann TH, Li Q, Ma HW, Key J, Zhang L, Chen R, Garcia JA, Naidoo J, Longgood J, Frantz DE, Tambar UK, Gardner KH, Bruick RK Nat. Chem. Biol. 2013 Feb

The hypoxic epicardial and subepicardial microenvironment.

Kocabas F, Mahmoud AI, Sosic D, Porrello ER, Chen R, Garcia JA, DeBerardinis RJ, Sadek HA J Cardiovasc Transl Res 2012 Oct 5 5 654-65

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