Download Curriculum Vitae

Ralph DeBerardinis earned a B.S. in biology from St. Joseph’s University and M.D. and Ph.D. degrees from the University of Pennsylvania. Dr. DeBerardinis was the first trainee in the combined residency program in pediatrics and medical genetics at The Children’s Hospital of Philadelphia (CHOP) and received several awards for teaching and clinical care. He ultimately achieved board certification in pediatrics, medical genetics and clinical biochemical genetics.

Dr. DeBerardinis performed postdoctoral research in Craig Thompson’s laboratory in the Penn Cancer Center from 2004 to 2007. He joined the faculty of the University of Texas Southwestern Medical Center in 2008 and joined the Children’s Medical Center Research Institute at UT Southwestern (CRI) shortly after its founding in 2012. Dr. DeBerardinis serves as chief of Pediatric Genetics and Metabolism at UT Southwestern and director of the Genetic and Metabolic Disease Program in the CRI.

The DeBerardinis laboratory is interested in the role of altered metabolic states in human diseases, particularly pediatric inborn errors of metabolism and cancer. This research is tightly integrated with clinical activities in medical genetics, oncology and radiology, providing seamless opportunities to examine the relevance of findings in patients.

DeBerardinis Laboratory


Medical School
University of Pennsylvania School of Medicine (2000)
Children's Hospital of Philadelphia (2005), Pediatrics & Medical Genetics

Research Interest

  • Cancer
  • Genetic disorders in children
  • Inborn errors of metabolism
  • Metabolism


Featured Publications LegendFeatured Publications

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation.
Liu X, Zhang Y, Ni M, Cao H, Signer RAJ, Li D, Li M, Gu Z, Hu Z, Dickerson KE, Weinberg SE, Chandel NS, DeBerardinis RJ, Zhou F, Shao Z, Xu J Nat. Cell Biol. 2017 Jun 19 6 626-638
The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling.
Sullivan LB, Garcia-Martinez E, Nguyen H, Mullen AR, Dufour E, Sudarshan S, Licht JD, Deberardinis RJ, Chandel NS Mol. Cell 2013 Jun
Cancer. Silencing a metabolic oncogene.
Kim J, DeBerardinis RJ Science 2013 May 340 6132 558-9

Honors & Awards

  • Howard Hughes Medical Institute Faculty Scholar
  • NCI Outstanding Investigator
  • Robert L. Moody, Sr. Faculty Scholar
  • Damon Runyon Cancer Research Foundation Clinical Investigator Award
  • President’s Research Council Distinguished Young Researcher Award
  • Soc. for Inherited Metabolic Disorders Neil Buist Award
  • Sowell Family Scholar in Medical Research
  • William K. Bowes, Jr. Award in Medical Genetics
  • CHOP Pediatric Scholars Program & Faculty Honor Roll
  • American Society for Clinical Investigation

Professional Associations/Affiliations

  • American Society for Clinical Investigation (2013)
  • American Academy of Pediatrics
  • American Association for Cancer Research
  • American Society of Human Genetics
  • Society for Inherited Metabolic Disorders
  • Society for Pediatrics Research