Dr. Rodan is a physician-scientist with an interest in hypertension, electrolyte disorders, and the underlying epithelial ion transport mechanisms in the kidney driving these clinical syndromes. She obtained her bachelor’s degree at Yale University and got started in her scientific career studying the role of endoplasmic reticulum chaperones in protein folding. She then enrolled in the Medical Scientist Training Program at UCSF, where she studied the mechanisms of behavioral changes in Drosophila melanogaster in response to alcohol, examining the effects of protein kinase A signaling in different parts of the brain, as well as the role of insulin signaling. Dr. Rodan continued at UCSF for an internal medicine residency, then moved to Dallas for nephrology fellowship training at UT Southwestern, where she deepened her understanding of renal physiology and clinical nephrology. The next logical step was to use Drosophila to study questions of relevance to mammalian renal physiology. Using this system, she is now studying ion channels and transporters, and the signaling cascades that regulate them, in the Drosophila renal tubule. The goal is to understand these transporters, channels and their regulation in greater mechanistic detail, identify new regulatory factors by performing forward genetic screens, and translate these insights into improved understanding of human kidney disorders. Dr. Rodan also see patients with kidney disorders and teaches medical students and housetaff, with an emphasis on renal physiology.
- Graduate School
- University of California at San Francisco (2002)
- Medical School
- University of California at San Diego (2004)
- University of California at San Francisco (2007), Internal Medicine
- University of Texas Southwestern Medical School (2008), Research
- UT Southwestern Medical Center (2011), Nephrology
- Epithelial ion transport
- Renal physiology
- Hypotonicity Stimulates Potassium Flux Through the WNK-SPAK/OSR1 Kinase Cascade and the Ncc69 Sodium-Potassium-2-Chloride Cotransporter in the Drosophila Renal Tubule.
- Wu Y, Schellinger JN, Huang CL, Rodan AR J. Biol. Chem. 2014 Aug
- The Drosophila NKCC Ncc69 is required for normal renal tubule function.
- Rodan AR, Baum M, Huang CL Am. J. Physiol., Cell Physiol. 2012 Oct 303 8 C883-94
- Recent advances in distal tubular potassium handling.
- Rodan AR, Cheng CJ, Huang CL Am. J. Physiol. Renal Physiol. 2011 Apr 300 4 F821-7
- An emerging role for SPAK in NCC, NKCC, and blood pressure regulation.
- Rodan AR, Huang CL J. Am. Soc. Nephrol. 2010 Nov 21 11 1812-4
- Distal potassium handling based on flow modulation of maxi-K channel activity.
- Rodan AR, Huang CL Curr. Opin. Nephrol. Hypertens. 2009 Jul 18 4 350-5
- Adult neuronal Arf6 controls ethanol-induced behavior with Arfaptin downstream of Rac1 and RhoGAP18B.
- Peru Y Colón de Portugal RL, Acevedo SF, Rodan AR, Chang LY, Eaton BA, Rothenfluh A J. Neurosci. 2012 Dec 32 49 17706-13
- The genetics of behavioral alcohol responses in Drosophila.
- Rodan AR, Rothenfluh A Int. Rev. Neurobiol. 2010 91 25-51
- Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster.
- Corl AB, Rodan AR, Heberlein U Nat. Neurosci. 2005 Jan 8 1 18-9
- High-resolution analysis of ethanol-induced locomotor stimulation in Drosophila.
- Wolf FW, Rodan AR, Tsai LT, Heberlein U J. Neurosci. 2002 Dec 22 24 11035-44
- Functional dissection of neuroanatomical loci regulating ethanol sensitivity in Drosophila.
- Rodan AR, Kiger JA, Heberlein U J. Neurosci. 2002 Nov 22 21 9490-501
Honors & Awards
- Outstanding research in genetics
Browne Genetic Research Fund (2015)
American Society of Nephrology (2014)
- Carl W. Gottschalk Research Scholar Grant
American Society of Nephrology (2013)
- Texas Rising Star
Super Doctors (2012-2014)
- K08 Career Development Award
- Pilot & Feasibility Award
UT Southwestern O'Brien Center (2011)
- 1st Prize, Basic Science
Young Investigator Forum, Southern Society of Clinical Investigation and National Kidney Foundation (2010)
- Chief Fellow
UT Southwestern (2009)
- Keith Johnson Award
University of California San Francisco (2006)
- Alpha Omega Alpha
University of California San Francisco (2004)
- Distinction in Biology
Yale University (1995)
- magna cum laude
Yale University (1995)
- Phi Beta Kappa
Yale University (1994)
- American Society of Nephrology (2008)