Xuewu Zhang, Ph.D.

Associate Professor

Endowed Title: Virginia Murchison Linthicum Scholar in Medical Research

Department: Pharmacology, Biophysics

Graduate Programs: Molecular Biophysics


Undergraduate Wuhan University - China (), Biology
Graduate School Albert Einstein College of Medicine (2003), Cell Biology

Research Interests

  • Signal transduction
  • Structural biology


Featured Publications Legend

Featured Publications

Structural basis for the prion-like MAVS filaments in antiviral innate immunity.

Xu H, He X, Zheng H, Huang LJ, Hou F, Yu Z, de la Cruz MJ, Borkowski B, Zhang X, Chen ZJ, Jiang QX Elife 2014 3 e01489

Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease.

Falta MT, Pinilla C, Mack DG, Tinega AN, Crawford F, Giulianotti M, Santos R, Clayton GM, Wang Y, Zhang X, Maier LA, Marrack P, Kappler JW, Fontenot AP J. Exp. Med. 2013 Jun

Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.

He X, Kuo YC, Rosche TJ, Zhang X Structure 2013 Mar 21 3 355-64

Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization.

Shan Y, Eastwood MP, Zhang X, Kim ET, Arkhipov A, Dror RO, Jumper J, Kuriyan J, Shaw DE Cell 2012 May 149 4 860-70

Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.

Jura N, Zhang X, Endres NF, Seeliger MA, Schindler T, Kuriyan J Mol. Cell 2011 Apr 42 1 9-22

Structural analysis and functional implications of the negative mTORC1 regulator REDD1.

Vega-Rubin-de-Celis S, Abdallah Z, Kinch L, Grishin NV, Brugarolas J, Zhang X Biochemistry 2010 Mar 49 11 2491-501

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.

Zhang X, Pickin KA, Bose R, Jura N, Cole PA, Kuriyan J Nature 2007 Nov 450 7170 741-4

Results 1-10 of 12


  • Virginia Murchison Linthicum Scholar in Medical Research
    UT Southwestern Medical Center (2007)
  • Julius Marmur Research Award
    Albert Einstein School of Medicine (2002)