Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin
Wang Y, Pascoe HG, Brautigam CA, He H, Zhang X. eLife 2013 2 e01279
Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization.
Wang Y, He H, Srivastava N, Vikarunnessa S, Chen YB, Jiang J, Cowan CW, Zhang X Sci Signal 2012 5 207 ra6
Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration.
He H, Yang T, Terman JR, Zhang X Proc. Natl. Acad. Sci. U.S.A. 2009 Sep 106 37 15610-5
Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease.
Falta MT, Pinilla C, Mack DG, Tinega AN, Crawford F, Giulianotti M, Santos R, Clayton GM, Wang Y, Zhang X, Maier LA, Marrack P, Kappler JW, Fontenot AP J. Exp. Med. 2013 Jun
Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.
He X, Kuo YC, Rosche TJ, Zhang X Structure 2013 Mar 21 3 355-64
Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization.
Shan Y, Eastwood MP, Zhang X, Kim ET, Arkhipov A, Dror RO, Jumper J, Kuriyan J, Shaw DE Cell 2012 May 149 4 860-70
Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.
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Structural analysis and functional implications of the negative mTORC1 regulator REDD1.
Vega-Rubin-de-Celis S, Abdallah Z, Kinch L, Grishin NV, Brugarolas J, Zhang X Biochemistry 2010 Mar 49 11 2491-501
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Zhang X, Pickin KA, Bose R, Jura N, Cole PA, Kuriyan J Nature 2007 Nov 450 7170 741-4
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor.
Zhang X, Gureasko J, Shen K, Cole PA, Kuriyan J Cell 2006 Jun 125 6 1137-49