Xuewu Zhang, Ph.D. Titles and Appointments Professor Endowed Title Virginia Murchison Linthicum Scholar in Medical Research Schools Medical School | Graduate School Departments Pharmacology | Biophysics Graduate Programs Molecular Biophysics Education Undergraduate Wuhan University (1995), Biology Graduate School Yeshiva Uni - Bronx Campus (2003), Cell Biology Research Interest Signal transduction Structural biology Publications Featured Publications Regulation of STING activation by phosphoinositide and cholesterol. Li J, Tan JX, Chen ZJ, Zhang X, Bai XC, Nature 2026 Feb PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling. Tan JX, Lv B, Li J, Li T, Du F, Chen X, Zhang X, Bai XC, Chen ZJ, Nature 2026 Feb Structural insights into the activation of the chicken ROS1 receptor by the NEL/NICOL ligand complex. An W, Zhang X, Bai XC, Nat Commun 2026 Feb Structural basis for ACT1 oligomerization induced by IL-17 receptor hetero-tetramer. Zhang H, Bai XC, Zhang X, Nat Commun 2025 Dec Secretogranin 2 binds LILRB4 resulting in immunosuppression. Yang X, Huang R, Fang M, He Y, Xie J, Liu X, Zhang C, Lou Q, Deng M, Xiong W, Lewis C, Sadek Z, Gupta A, Chen L, Zhang X, Guo L, Xu L, Zhang N, An Z, Zhang CC, Nat Immunol 2025 Jul Mouse radial spoke 3 is a metabolic and regulatory hub in cilia. Zhao Y, Song K, Tavakoli A, Gui L, Fernandez-Gonzalez A, Zhang S, Dzeja PP, Mitsialis SA, Zhang X, Nicastro D, Nat Struct Mol Biol 2025 Jun LILRB3 genetic variation is associated with kidney transplant failure in African American recipients. Sun Z, Yi Z, Wei C, Wang W, Ren T, Cravedi P, Tedla F, Ward SC, Azeloglu E, Schrider DR, Li Y, Khan A, Zanoni F, Fu J, Ali S, Liu S, Liang D, Liu T, Li H, Xi C, Vy TH, Mosoyan G, Sun Q, Kumar A, Zhang Z, Farouk S, Campell K, Ochando J, Lee K, Coca S, Xiang J, Connolly P, Gallon L, O'Connell PJ, Colvin R, Menon MC, Nadkarni G, He JC, Kraft M, Jiang X, Zhang X, Kiryluk K, Cherukuri A, Lakkis FG, Zhang W, Chen SH, Heeger PS, Zhang W, Nat Med 2025 Mar Helical reconstruction of VP39 reveals principles for baculovirus nucleocapsid assembly. Benning FMC, Jenni S, Garcia CY, Nguyen TH, Zhang X, Chao LH, Nat Commun 2024 Jan 15 1 250 Applications of cryo-EM in drug development for STING. Bai XC, Zhang X, Curr Opin Struct Biol 2024 Jan 84 102767 Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma. Hu L, Zhang Y, Guo L, Zhong H, Xie L, Zhou J, Liao C, Yao H, Fang J, Liu H, Zhang C, Zhang H, Zhu X, Luo M, von Kriegsheim A, Li B, Luo W, Zhang X, Chen X, Mendell JT, Xu L, Kapur P, Baldwin AS, Brugarolas J, Zhang Q, Mol Cell 2024 Jan Results 1-10 of 62 1 2 3 4 5 Next Last Honors & Awards Virginia Murchison Linthicum Scholar in Medical ResearchUT Southwestern Medical Center (2007) Julius Marmur Research AwardAlbert Einstein School of Medicine (2002)
