The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold.
Selyunin AS, Sutton SE, Weigele BA, Reddick LE, Orchard RC, Bresson SM, Tomchick DR, Alto NM Nature 2011 Jan 469 7328 107-11
Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics.
Huang Z, Sutton SE, Wallenfang AJ, Orchard RC, Wu X, Feng Y, Chai J, Alto NM Nat. Struct. Mol. Biol. 2009 Aug 16 8 853-60
Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation.
Ohlson MB, Huang Z, Alto NM, Blanc MP, Dixon JE, Chai J, Miller SI Cell Host Microbe 2008 Nov 4 5 434-46
The Type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways.
Alto NM et al. The Journal of Cell Biology September 2007 24;178(7) 1265-78
Identification of a Bacterial Type III Effector Family with G Protein Mimicry Functions
Alto NM, Shao F, Lazar CS, Brost RL, Chua G, Mattoo S, McMahon SA, Ghosh P, Hughes TR, Boone C, Dixon JE Cell January 2006 124 1-13
Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex
Westphal RS, Tavalin SJ, Lin JW, Alto NM, Fraser ID, Langeberg LK, Sheng M, Scott JD Science July 1999 285(5424) 93-6
Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit.
Orchard RO, Kittisopikul M, Altschuler SJ, Wu LF, Suel GM, and Alto NM Cell 2012 Feb (in press)