TLR-independent neutrophil-derived IFN-? is important for host resistance to intracellular pathogens.
Sturge CR, Benson A, Raetz M, Wilhelm CL, Mirpuri J, Vitetta ES, Yarovinsky F Proc. Natl. Acad. Sci. U.S.A. 2013 Jun 110 26 10711-6
Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-?-dependent elimination of Paneth cells.
Raetz M, Hwang SH, Wilhelm CL, Kirkland D, Benson A, Sturge CR, Mirpuri J, Vaishnava S, Hou B, Defranco AL, Gilpin CJ, Hooper LV, Yarovinsky F Nat. Immunol. 2013 Feb 14 2 136-42
Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors.
Hou B, Benson A, Kuzmich L, DeFranco AL, Yarovinsky F. PNAS January 2011 108(1) 278-83
Gut commensal bacteria direct a protective immune response against Toxoplasma gondii
Alicia Benson, Reed Pifer, Cassie L. Behrendt, Lora V. Hooper, Felix Yarovinsky Cell Host&Microbe August 2009 6(2) 187-96
TLR11 activation of dendritic cells by a protozoan profilin-like protein
Yarovinsky F, Zhang D, Andersen JF, Bannenberg GL, Serhan CN, Hayden MS, Hieny S, Sutterwala FS, Flavell RA, Ghosh S, Sher A Science June 2005 10;308(5728) 1626-9
Innate responses to Toxoplasma gondii in mice and humans.
Pifer R, Yarovinsky F. Trends in Parasitology May 2011 in press
UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii.
Pifer R, Benson A, Sturge CR, Yarovinsky F. J Biol Chem February 2011 286(5) 3307-14